has_related_synonym
type: AnnotationProperty

has_alternative_id
type: AnnotationProperty

has_narrow_synonym
type: AnnotationProperty

in_subset
type: AnnotationProperty

term replaced by
type: AnnotationProperty

imported from
type: AnnotationProperty

definition
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty

term tracker item
type: AnnotationProperty
database_cross_reference: IAO:0000233
has_obo_namespace: external
id: term_tracker_item
shorthand: term_tracker_item
is class level: true
is metadata tag: true

has_broad_synonym
type: AnnotationProperty

consider
type: AnnotationProperty

has_obo_namespace
type: AnnotationProperty

has_exact_synonym
type: AnnotationProperty

shorthand
type: AnnotationProperty

mitotic G1 phase
type: Class
subclass of: G1 phase
has_exact_synonym: G1 phase of mitotic cell cycle
id: GO:0000080
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
definition: The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis.
has_obo_namespace: biological_process
in_subset: gocheck do not annotate
imported from: go.owl

mitotic S phase
type: Class
subclass of: S phase
id: GO:0000084
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
has_exact_synonym: S phase of mitotic cell cycle
has_exact_synonym: S-phase of mitotic cell cycle
definition: The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle.
has_obo_namespace: biological_process
in_subset: gocheck do not annotate
imported from: go.owl

mitotic G2 phase
type: Class
subclass of: G2 phase
has_exact_synonym: G2 phase of mitotic cell cycle
id: GO:0000085
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
definition: The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis.
has_obo_namespace: biological_process
in_subset: gocheck do not annotate
imported from: go.owl

mitotic M phase
type: Class
subclass of: M phase
definition: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle.
id: GO:0000087
has_exact_synonym: M phase of mitotic cell cycle
has_exact_synonym: M-phase of mitotic cell cycle
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
has_obo_namespace: biological_process
in_subset: gocheck do not annotate
imported from: go.owl

obsolete MAPK import into nucleus
type: Class
subclass of: protein import into nucleus
id: GO:0000189
consider: GO:0006606
definition: OBSOLETE. The directed movement of a MAP kinase to the nucleus upon activation.
comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models.
has_obo_namespace: biological_process
has_narrow_synonym: nuclear translocation of MAPK
deprecated: true
imported from: go.owl

mitotic cell cycle
type: Class
subclass of: cell cycle
id: GO:0000278
has_alternative_id: GO:0007067
comment: Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle.
definition: Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
database_cross_reference: Wikipedia:Mitosis
has_obo_namespace: biological_process
has_related_synonym: mitosis
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim yeast
imported from: go.owl

M phase
type: Class
subclass of: cell cycle phase
definition: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase.
id: GO:0000279
has_exact_synonym: M-phase
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
database_cross_reference: Wikipedia:M_phase
has_obo_namespace: biological_process
in_subset: gocheck do not annotate
imported from: go.owl

response to reactive oxygen species
type: Class
subclass of: GO_0008150
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
id: GO:0000302
has_obo_namespace: biological_process
has_exact_synonym: response to AOS
has_exact_synonym: response to ROI
has_exact_synonym: response to ROS
has_exact_synonym: response to active oxygen species
has_exact_synonym: response to reactive oxidative species
has_exact_synonym: response to reactive oxygen intermediate
imported from: go.owl

alternative mRNA splicing, via spliceosome
type: Class
subclass of: GO_0008150
id: GO:0000380
comment: Note that this process most commonly occurs in cis, selecting or skipping exons from the same primary transcript, but it has also been observed to occur in trans at low frequency, at least in some mammals.
definition: The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.
has_exact_synonym: alternative nuclear mRNA splicing, via spliceosome
has_obo_namespace: biological_process
has_broad_synonym: splice site selection
imported from: go.owl

nucleosome
type: Class
subclass of: GO_0005575
definition: A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.
id: GO:0000786
has_alternative_id: GO:0000787
has_alternative_id: GO:0000788
has_alternative_id: GO:0005718
database_cross_reference: Wikipedia:Nucleosome
has_obo_namespace: cellular_component
has_narrow_synonym: cytoplasmic nucleosome
has_narrow_synonym: nuclear nucleosome
in_subset: goslim pir
imported from: go.owl

dopamine neurotransmitter receptor activity, coupled via Gs
type: Class
subclass of: signaling
definition: Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity.
id: GO:0001588
has_alternative_id: GO:0001589
has_alternative_id: GO:0001590
has_narrow_synonym: dopamine D1 receptor activity
has_narrow_synonym: dopamine D5 receptor activity
has_obo_namespace: molecular_function
imported from: go.owl

dopamine neurotransmitter receptor activity, coupled via Gi/Go
type: Class
subclass of: GO_0004872
definition: Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity.
id: GO:0001591
has_alternative_id: GO:0001592
has_alternative_id: GO:0001593
has_alternative_id: GO:0001670
has_narrow_synonym: dopamine D2 receptor activity
has_narrow_synonym: dopamine D3 receptor activity
has_narrow_synonym: dopamine D4 receptor activity
has_obo_namespace: molecular_function
imported from: go.owl

response to hypoxia
type: Class
subclass of: GO_0008150
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
id: GO:0001666
comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%.
has_obo_namespace: biological_process
has_exact_synonym: response to hypoxic stress
has_narrow_synonym: response to intermittent hypoxia
has_exact_synonym: response to lowered oxygen tension
has_narrow_synonym: response to sustained hypoxia
imported from: go.owl

cytokine production
type: Class
subclass of: GO_0008150
id: GO:0001816
has_alternative_id: GO:0042032
has_alternative_id: GO:0042089
has_alternative_id: GO:0042107
has_alternative_id: GO:0050663
comment: Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules.
definition: The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_obo_namespace: biological_process
has_narrow_synonym: cytokine biosynthetic process
has_narrow_synonym: cytokine metabolic process
has_narrow_synonym: cytokine secretion
term tracker item: https://github.com/geneontology/go-ontology/issues/19116
has_narrow_synonym: interferon production
has_narrow_synonym: interferon secretion
has_narrow_synonym: interleukin production
has_narrow_synonym: interleukin secretion
in_subset: gocheck do not annotate
in_subset: goslim pir
imported from: go.owl

obsolete steroid hormone receptor import into nucleus
type: Class
subclass of: GO_0008150
creation date: 2009-07-09T02:34:42Z
id: GO:0002146
consider: GO:0006606
consider: GO:0042306
definition: OBSOLETE. The directed movement of a steroid hormone receptor into the nucleus.
comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models.
has_obo_namespace: biological_process
created by: hjd
has_narrow_synonym: steroid hormone receptor nuclear translocation
deprecated: true
imported from: go.owl

obsolete glucocorticoid receptor import into nucleus
type: Class
subclass of: GO_0008150
creation date: 2009-07-09T02:36:09Z
id: GO:0002147
consider: GO:0042306
definition: OBSOLETE. The directed movement of a glucocorticoid receptor into the nucleus.
comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models.
has_obo_namespace: biological_process
has_narrow_synonym: glucocorticoid receptor nuclear translocation
created by: hjd
deprecated: true
imported from: go.owl

thrombocyte differentiation
type: Class
subclass of: GO_0008150
id: GO:0002574
comment: Note that platelets are the non-nucleated mammalian functional equivalent of the nucleated thrombocytes of non-mammalian vertebrates and are sometimes also referred to as thrombocytes. Platelet formation in mammals is covered by the biological_process term platelet formation ; GO:0030220.
definition: The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis.
has_obo_namespace: biological_process
imported from: go.owl

regulation of acute inflammatory response
type: Class
subclass of: GO_0008150
definition: Any process that modulates the frequency, rate, or extent of an acute inflammatory response.
id: GO:0002673
has_obo_namespace: biological_process
imported from: go.owl

catalytic activity
type: Class
subclass of: GO_0003674
definition: Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
id: GO:0003824
database_cross_reference: Wikipedia:Enzyme
has_exact_synonym: enzyme activity
has_obo_namespace: molecular_function
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
imported from: go.owl

GTPase activity
type: Class
subclass of: GO_0008150
creation date: 2015-11-11T12:47:56Z
has_narrow_synonym: ARF small monomeric GTPase activity
definition: Catalysis of the reaction: GTP + H2O = GDP + phosphate.
id: GO:0003924
has_alternative_id: GO:0061745
has_related_synonym: GTPase activity, coupled
database_cross_reference: RHEA:19669
has_narrow_synonym: RHEB small monomeric GTPase activity
has_narrow_synonym: Rab small monomeric GTPase activity
has_narrow_synonym: Ran small monomeric GTPase activity
has_narrow_synonym: Ras small monomeric GTPase activity
database_cross_reference: Reactome:R-HSA-1445143
database_cross_reference: Reactome:R-HSA-1458485
database_cross_reference: Reactome:R-HSA-156923
database_cross_reference: Reactome:R-HSA-164381
database_cross_reference: Reactome:R-HSA-165055
database_cross_reference: Reactome:R-HSA-167415
database_cross_reference: Reactome:R-HSA-170666
database_cross_reference: Reactome:R-HSA-170685
database_cross_reference: Reactome:R-HSA-170686
database_cross_reference: Reactome:R-HSA-177501
database_cross_reference: Reactome:R-HSA-203973
database_cross_reference: Reactome:R-HSA-2130641
database_cross_reference: Reactome:R-HSA-2130725
database_cross_reference: Reactome:R-HSA-2584246
database_cross_reference: Reactome:R-HSA-380979
database_cross_reference: Reactome:R-HSA-392133
database_cross_reference: Reactome:R-HSA-392212
database_cross_reference: Reactome:R-HSA-418574
database_cross_reference: Reactome:R-HSA-418582
database_cross_reference: Reactome:R-HSA-421835
database_cross_reference: Reactome:R-HSA-428941
database_cross_reference: Reactome:R-HSA-432707
database_cross_reference: Reactome:R-HSA-5333615
database_cross_reference: Reactome:R-HSA-5389839
database_cross_reference: Reactome:R-HSA-5389842
database_cross_reference: Reactome:R-HSA-5419273
database_cross_reference: Reactome:R-HSA-5419279
database_cross_reference: Reactome:R-HSA-555065
database_cross_reference: Reactome:R-HSA-5623513
database_cross_reference: Reactome:R-HSA-5638006
database_cross_reference: Reactome:R-HSA-5658231
database_cross_reference: Reactome:R-HSA-5665809
database_cross_reference: Reactome:R-HSA-5672017
database_cross_reference: Reactome:R-HSA-5694527
database_cross_reference: Reactome:R-HSA-6807877
database_cross_reference: Reactome:R-HSA-6814833
database_cross_reference: Reactome:R-HSA-8847534
database_cross_reference: Reactome:R-HSA-8847883
database_cross_reference: Reactome:R-HSA-8849082
database_cross_reference: Reactome:R-HSA-8854173
database_cross_reference: Reactome:R-HSA-8854255
database_cross_reference: Reactome:R-HSA-8854329
database_cross_reference: Reactome:R-HSA-8854604
database_cross_reference: Reactome:R-HSA-8854612
database_cross_reference: Reactome:R-HSA-8868661
database_cross_reference: Reactome:R-HSA-8981353
database_cross_reference: Reactome:R-HSA-8982020
database_cross_reference: Reactome:R-HSA-8982021
database_cross_reference: Reactome:R-HSA-8982025
database_cross_reference: Reactome:R-HSA-9640195
database_cross_reference: Reactome:R-HSA-9645598
database_cross_reference: Reactome:R-HSA-9649736
database_cross_reference: Reactome:R-HSA-983422
has_narrow_synonym: Rho small monomeric GTPase activity
has_narrow_synonym: Sar small monomeric GTPase activity
created by: dph
has_narrow_synonym: dynamin GTPase activity
has_narrow_synonym: heterotrimeric G-protein GTPase activity
has_related_synonym: heterotrimeric G-protein GTPase, alpha-subunit
has_related_synonym: heterotrimeric G-protein GTPase, beta-subunit
has_related_synonym: heterotrimeric G-protein GTPase, gamma-subunit
term tracker item: https://github.com/geneontology/go-ontology/issues/19078
has_broad_synonym: hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
has_obo_namespace: molecular_function
has_narrow_synonym: protein-synthesizing GTPase activity
has_narrow_synonym: protein-synthesizing GTPase activity, elongation

GO_0004872
type: Class
subclass of: GO_0003674
deprecated: true
term replaced by: GO_0038023
IAO_0000231: IAO_0000227
imported from: go.owl

beta-adrenergic receptor activity
type: Class
subclass of: GO_0004872
definition: Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein.
id: GO:0004939
has_exact_synonym: beta adrenoceptor
has_obo_namespace: molecular_function
imported from: go.owl

signaling receptor binding
type: Class
subclass of: protein binding
id: GO:0005102
definition: Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
comment: Where appropriate, also consider annotating to 'receptor agonist activity ; GO:0048018'.
database_cross_reference: Wikipedia:Ligand_(biochemistry)
has_obo_namespace: molecular_function
has_broad_synonym: receptor binding
has_narrow_synonym: receptor ligand
has_related_synonym: receptor-associated protein activity
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim plant
imported from: go.owl

binding
type: Class
subclass of: GO_0003674
id: GO:0005488
comment: Note that this term is in the subset of terms that should not be used for direct, manual gene product annotation. Please choose a more specific child term, or request a new one if no suitable term is available. For ligands that bind to signal transducing receptors, consider the molecular function term 'receptor binding ; GO:0005102' and its children.
definition: The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
database_cross_reference: Wikipedia:Binding_(molecular)
has_narrow_synonym: ligand
has_obo_namespace: molecular_function
in_subset: gocheck do not annotate
in_subset: goslim pir
in_subset: goslim plant
imported from: go.owl

protein binding
type: Class
subclass of: binding
has_alternative_id: GO:0001948
id: GO:0005515
has_alternative_id: GO:0045308
definition: Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
has_narrow_synonym: glycoprotein binding
has_obo_namespace: molecular_function
has_exact_synonym: protein amino acid binding
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
imported from: go.owl

nucleus
type: Class
subclass of: GO_0005575
definition: A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
id: GO:0005634
database_cross_reference: NIF_Subcellular:sao1702920020
database_cross_reference: Wikipedia:Cell_nucleus
has_exact_synonym: cell nucleus
has_obo_namespace: cellular_component
has_narrow_synonym: horsetail nucleus
in_subset: goslim agr
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast
imported from: go.owl

nuclear envelope
type: Class
subclass of: GO_0005575
id: GO:0005635
has_alternative_id: GO:0005636
definition: The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
database_cross_reference: Wikipedia:Nuclear_envelope
has_obo_namespace: cellular_component
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim plant
imported from: go.owl

cytoplasm
type: Class
subclass of: GO_0005575
definition: All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
id: GO:0005737
database_cross_reference: Wikipedia:Cytoplasm
has_obo_namespace: cellular_component
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast
imported from: go.owl

mitochondrion
type: Class
subclass of: GO_0005575
definition: A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
id: GO:0005739
database_cross_reference: NIF_Subcellular:sao1860313010
comment: Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.)
database_cross_reference: Wikipedia:Mitochondrion
has_obo_namespace: cellular_component
has_exact_synonym: mitochondria
in_subset: goslim agr
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast
imported from: go.owl

lysosome
type: Class
subclass of: GO_0005575
definition: A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
id: GO:0005764
database_cross_reference: NIF_Subcellular:sao585356902
database_cross_reference: Wikipedia:Lysosome
has_obo_namespace: cellular_component
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim plant
imported from: go.owl

autophagosome
type: Class
subclass of: GO_0005575
definition: A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy.
id: GO:0005776
database_cross_reference: NIF_Subcellular:sao8663416959
has_exact_synonym: autophagic vacuole
has_obo_namespace: cellular_component
has_related_synonym: initial autophagic vacuole
imported from: go.owl

endoplasmic reticulum
type: Class
subclass of: GO_0005575
has_exact_synonym: ER
id: GO:0005783
database_cross_reference: NIF_Subcellular:sao1036339110
definition: The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
database_cross_reference: Wikipedia:Endoplasmic_reticulum
has_obo_namespace: cellular_component
in_subset: goslim agr
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast
imported from: go.owl

Golgi apparatus
type: Class
subclass of: GO_0005575
definition: A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
id: GO:0005794
has_broad_synonym: Golgi
has_exact_synonym: Golgi complex
has_narrow_synonym: Golgi ribbon
database_cross_reference: NIF_Subcellular:sao451912436
comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.
database_cross_reference: Wikipedia:Golgi_apparatus
has_obo_namespace: cellular_component
in_subset: goslim agr
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast
imported from: go.owl

cytosol
type: Class
subclass of: GO_0005575
id: GO:0005829
database_cross_reference: NIF_Subcellular:sao101633890
definition: The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
database_cross_reference: Wikipedia:Cytosol
has_obo_namespace: cellular_component
in_subset: goslim agr
in_subset: goslim aspergillus
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant
imported from: go.owl

plasma membrane
type: Class
subclass of: GO_0005575
id: GO:0005886
has_alternative_id: GO:0005904
database_cross_reference: NIF_Subcellular:sao1663586795
definition: The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
database_cross_reference: Wikipedia:Cell_membrane
has_narrow_synonym: bacterial inner membrane
has_exact_synonym: cell membrane
has_exact_synonym: cellular membrane
has_obo_namespace: cellular_component
has_exact_synonym: cytoplasmic membrane
has_narrow_synonym: inner endospore membrane
has_broad_synonym: juxtamembrane
has_narrow_synonym: plasma membrane lipid bilayer
has_exact_synonym: plasmalemma
in_subset: goslim agr
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim mouse
in_subset: goslim plant
in_subset: goslim yeast
imported from: go.owl

DNA repair
type: Class
subclass of: GO_0008150
id: GO:0006281
definition: The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
database_cross_reference: Wikipedia:DNA_repair
has_obo_namespace: biological_process
in_subset: goslim drosophila
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim yeast
imported from: go.owl

transcription, DNA-templated
type: Class
subclass of: gene expression
has_exact_synonym: DNA-dependent transcription
has_alternative_id: GO:0006350
id: GO:0006351
has_alternative_id: GO:0061018
has_alternative_id: GO:0061022
definition: The cellular synthesis of RNA on a template of DNA.
database_cross_reference: Wikipedia:Transcription_(genetics)
has_obo_namespace: biological_process
has_broad_synonym: cellular transcription
has_exact_synonym: cellular transcription, DNA-dependent
has_broad_synonym: transcription
has_related_synonym: transcription regulator activity
has_exact_synonym: transcription, DNA-dependent
in_subset: goslim aspergillus
in_subset: goslim drosophila
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim pombe
imported from: go.owl

regulation of transcription, DNA-templated
type: Class
subclass of: GO_0008150
definition: Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
id: GO:0006355
has_alternative_id: GO:0032583
has_alternative_id: GO:0045449
has_alternative_id: GO:0061019
has_obo_namespace: biological_process
has_exact_synonym: regulation of cellular transcription, DNA-dependent
has_related_synonym: regulation of gene-specific transcription
has_exact_synonym: regulation of transcription, DNA-dependent
has_broad_synonym: transcriptional control
imported from: go.owl

translation
type: Class
subclass of: gene expression
id: GO:0006412
has_alternative_id: GO:0006416
has_alternative_id: GO:0006453
has_alternative_id: GO:0043037
definition: The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
database_cross_reference: Wikipedia:Translation_(genetics)
has_obo_namespace: biological_process
has_exact_synonym: protein anabolism
has_exact_synonym: protein biosynthesis
has_exact_synonym: protein biosynthetic process
has_exact_synonym: protein formation
has_exact_synonym: protein synthesis
has_exact_synonym: protein translation
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
imported from: go.owl

regulation of translation
type: Class
subclass of: GO_0008150
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
id: GO:0006417
has_alternative_id: GO:0006445
has_obo_namespace: biological_process
has_exact_synonym: regulation of protein anabolism
has_exact_synonym: regulation of protein biosynthesis
has_exact_synonym: regulation of protein formation
has_exact_synonym: regulation of protein synthesis
in_subset: goslim yeast
imported from: go.owl

protein phosphorylation
type: Class
subclass of: GO_0008150
id: GO:0006468
definition: The process of introducing a phosphate group on to a protein.
has_obo_namespace: biological_process
has_exact_synonym: protein amino acid phosphorylation
in_subset: goslim yeast
imported from: go.owl

protein dephosphorylation
type: Class
subclass of: GO_0008150
id: GO:0006470
definition: The process of removing one or more phosphoric residues from a protein.
has_obo_namespace: biological_process
has_exact_synonym: protein amino acid dephosphorylation
in_subset: goslim yeast
imported from: go.owl

protein import into nucleus
type: Class
subclass of: GO_0008150
id: GO:0006606
definition: The directed movement of a protein from the cytoplasm to the nucleus.
has_obo_namespace: biological_process
has_exact_synonym: establishment of protein localization to nucleus
has_exact_synonym: protein import into cell nucleus
has_exact_synonym: protein nucleus import
has_exact_synonym: protein transport from cytoplasm to nucleus
imported from: go.owl

chloride transport
type: Class
subclass of: GO_0008150
id: GO:0006821
definition: The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_obo_namespace: biological_process
imported from: go.owl

autophagy
type: Class
subclass of: GO_0008150
id: GO:0006914
has_alternative_id: GO:0016238
definition: The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
database_cross_reference: Wikipedia:Autophagy_(cellular)
has_obo_namespace: biological_process
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
imported from: go.owl

apoptotic process
type: Class
subclass of: GO_0008150
definition: A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
id: GO:0006915
has_alternative_id: GO:0006917
has_alternative_id: GO:0008632
database_cross_reference: Wikipedia:Apoptosis
has_narrow_synonym: activation of apoptosis
has_narrow_synonym: apoptosis
has_related_synonym: apoptosis activator activity
has_narrow_synonym: apoptosis signaling
has_exact_synonym: apoptotic cell death
has_narrow_synonym: apoptotic program
has_exact_synonym: apoptotic programmed cell death
has_obo_namespace: biological_process
has_related_synonym: caspase-dependent programmed cell death
has_broad_synonym: cell suicide
has_broad_synonym: cellular suicide
has_related_synonym: commitment to apoptosis
has_related_synonym: induction of apoptosis
has_related_synonym: induction of apoptosis by p53
has_exact_synonym: programmed cell death by apoptosis
has_related_synonym: signaling (initiator) caspase activity
has_narrow_synonym: type I programmed cell death
RO_0002161: NCBITaxon 2
RO_0002161: NCBITaxon 4896
imported from: go.owl

response to stress
type: Class
subclass of: GO_0008150
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
id: GO:0006950
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
has_obo_namespace: biological_process
has_related_synonym: response to abiotic stress
has_related_synonym: response to biotic stress
in_subset: gocheck do not manually annotate
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim plant
imported from: go.owl

inflammatory response
type: Class
subclass of: GO_0008150
id: GO:0006954
definition: The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
database_cross_reference: Wikipedia:Inflammation
has_obo_namespace: biological_process
has_broad_synonym: inflammation
imported from: go.owl

cell cycle
type: Class
subclass of: GO_0008150
id: GO:0007049
definition: The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
database_cross_reference: Wikipedia:Cell_cycle
has_obo_namespace: biological_process
has_exact_synonym: cell-division cycle
in_subset: gocheck do not manually annotate
in_subset: goslim agr
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
imported from: go.owl

cell cycle arrest
type: Class
subclass of: GO_0008150
definition: A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
id: GO:0007050
has_exact_synonym: arrest of cell cycle progression
has_obo_namespace: biological_process
has_exact_synonym: cessation of cell cycle
has_exact_synonym: termination of cell cycle
imported from: go.owl

signal transduction
type: Class
subclass of: GO_0008150
id: GO:0007165
has_alternative_id: GO:0023033
comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.
definition: The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
database_cross_reference: Wikipedia:Signal_transduction
has_obo_namespace: biological_process
has_narrow_synonym: signaling cascade
has_related_synonym: signaling pathway
has_narrow_synonym: signalling cascade
has_related_synonym: signalling pathway
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim chembl
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim plant
imported from: go.owl

G protein-coupled receptor signaling pathway
type: Class
subclass of: GO_0008150
definition: A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
has_exact_synonym: G protein coupled receptor protein signaling pathway
has_exact_synonym: G protein coupled receptor protein signalling pathway
has_exact_synonym: G-protein coupled receptor protein signal transduction
has_exact_synonym: G-protein coupled receptor protein signaling pathway
has_narrow_synonym: G-protein coupled receptor signaling pathway via GPCR dimer
has_exact_synonym: G-protein coupled receptor signalling pathway
has_exact_synonym: G-protein-coupled receptor protein signalling pathway
id: GO:0007186
has_alternative_id: GO:0038042
has_exact_synonym: GPCR signaling pathway
has_exact_synonym: GPCR signalling pathway
has_obo_namespace: biological_process
has_narrow_synonym: dimeric G-protein coupled receptor signaling pathway
has_narrow_synonym: dimeric G-protein coupled receptor signalling pathway
in_subset: goslim drosophila
imported from: go.owl

receptor signaling pathway via JAK-STAT
type: Class
subclass of: GO_0008150
definition: Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.
id: GO:0007259
has_narrow_synonym: JAK-STAT cascade
has_exact_synonym: JAK-STAT signal transduction
database_cross_reference: Wikipedia:JAK-STAT_signaling_pathway
has_obo_namespace: biological_process
imported from: go.owl

neurotransmitter secretion
type: Class
subclass of: GO_0008150
comment: A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.
id: GO:0007269
has_alternative_id: GO:0010554
definition: The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
has_obo_namespace: biological_process
has_exact_synonym: neurotransmitter release
has_exact_synonym: neurotransmitter secretory pathway
in_subset: goslim synapse
imported from: go.owl

circadian rhythm
type: Class
subclass of: GO_0008150
definition: Any biological process in an organism that recurs with a regularity of approximately 24 hours.
id: GO:0007623
has_alternative_id: GO:0050895
database_cross_reference: Wikipedia:Circadian_rhythm
has_obo_namespace: biological_process
has_exact_synonym: circadian process
has_related_synonym: circadian response
has_related_synonym: response to circadian rhythm
in_subset: goslim drosophila
in_subset: goslim plant
imported from: go.owl

drug binding
type: Class
subclass of: binding
id: GO:0008144
definition: Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
has_obo_namespace: molecular_function
in_subset: goslim pir
imported from: go.owl

cell death
type: Class
subclass of: GO_0008150
definition: Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
id: GO:0008219
comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term.
has_related_synonym: accidental cell death
has_obo_namespace: biological_process
has_related_synonym: necrosis
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim plant
imported from: go.owl

cell population proliferation
type: Class
subclass of: GO_0008150
id: GO:0008283
definition: The multiplication or reproduction of cells, resulting in the expansion of a cell population.
comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms.
has_obo_namespace: biological_process
has_related_synonym: cell proliferation
in_subset: goslim agr
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim flybase ribbon
in_subset: goslim generic
in_subset: goslim mouse
in_subset: goslim pir
RO_0002161: NCBITaxon 4751
imported from: go.owl

fatty acid catabolic process
type: Class
subclass of: GO_0008150
id: GO:0009062
definition: The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
database_cross_reference: Wikipedia:Fatty_acid_degradation
has_obo_namespace: biological_process
has_exact_synonym: fatty acid breakdown
has_exact_synonym: fatty acid catabolism
has_exact_synonym: fatty acid degradation
imported from: go.owl

quorum sensing
type: Class
subclass of: GO_0008150
id: GO:0009372
has_alternative_id: GO:0010699
has_alternative_id: GO:0060247
definition: The cell-cell signaling process in which single-celled organisms carry out coordinated responses by monitoring their own population density, and often also that of other microbes, by producing small, diffusible, signal molecules, detecting the concentration of these molecules, and triggering a signal transduction pathway when a certain threshold is reached. Quorum sensing can occur amongst microbial communities in the environment or within host organisms.
database_cross_reference: Wikipedia:Quorum_sensing
has_obo_namespace: biological_process
has_related_synonym: cell-cell signaling involved in quorum sensing
has_related_synonym: detection of cell density by secreted molecule
has_exact_synonym: quorum sensing system
in_subset: goslim metagenomics
in_subset: goslim pir
imported from: go.owl

cell surface
type: Class
subclass of: GO_0005575
has_alternative_id: GO:0009928
has_alternative_id: GO:0009929
id: GO:0009986
comment: Note that this term is intended to annotate gene products that are attached (integrated or loosely bound) to the plasma membrane or cell wall.
definition: The external part of the cell wall and/or plasma membrane.
has_exact_synonym: cell associated
has_exact_synonym: cell bound
has_obo_namespace: cellular_component
in_subset: goslim pir
imported from: go.owl

gene expression
type: Class
subclass of: GO_0008150
id: GO:0010467
definition: The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
database_cross_reference: Wikipedia:Gene_expression
has_obo_namespace: biological_process
in_subset: goslim flybase ribbon
imported from: go.owl

regulation of gene expression
type: Class
subclass of: GO_0008150
definition: Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
id: GO:0010468
comment: This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation.
database_cross_reference: Wikipedia:Regulation_of_gene_expression
has_obo_namespace: biological_process
has_related_synonym: regulation of gene product expression
has_narrow_synonym: regulation of protein expression
imported from: go.owl

protein kinase A signaling
type: Class
subclass of: GO_0008150
definition: A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound.
id: GO:0010737
has_related_synonym: PKA signaling cascade
has_obo_namespace: biological_process
has_exact_synonym: protein kinase A signal transduction
has_related_synonym: protein kinase A signaling cascade
has_related_synonym: protein kinase A signalling cascade
imported from: go.owl

positive regulation of lipid storage
type: Class
subclass of: GO_0008150
definition: Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
id: GO:0010884
has_obo_namespace: biological_process
has_narrow_synonym: positive regulation of lipid sequestration
imported from: go.owl

negative regulation of lipid storage
type: Class
subclass of: GO_0008150
definition: Any process that decreases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
id: GO:0010888
has_obo_namespace: biological_process
imported from: go.owl

drug transport
type: Class
subclass of: GO_0008150
id: GO:0015893
definition: The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_obo_namespace: biological_process
in_subset: goslim pir
imported from: go.owl

viral process
type: Class
subclass of: GO_0008150
definition: A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.
id: GO:0016032
has_alternative_id: GO:0022415
comment: See also the biological process terms 'viral infectious cycle ; GO:0019058' and 'lysogeny ; GO:0030069'.
database_cross_reference: Wikipedia:Viral_life_cycle
has_obo_namespace: biological_process
has_related_synonym: viral infection
has_related_synonym: virulence
has_exact_synonym: virus process
in_subset: goslim metagenomics
in_subset: goslim pir
RO_0002161: NCBITaxon 4751
imported from: go.owl

RNA interference
type: Class
subclass of: GO_0008150
id: GO:0016246
comment: Note that this term refers specifically to posttranscriptional mechanisms by which small interfering RNAs down-regulate gene expression. Also consider annotating to other descendants of 'gene silencing by RNA ; GO:0031047'.
has_exact_synonym: RNAi
definition: The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes.
database_cross_reference: Wikipedia:RNA_interference
has_obo_namespace: biological_process
has_exact_synonym: posttranscriptional gene silencing by siRNA
RO_0002161: NCBITaxon 4895
imported from: go.owl

kinase activity
type: Class
subclass of: GO_0003674
definition: Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
id: GO:0016301
comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term.
database_cross_reference: Reactome:R-HSA-6788855
database_cross_reference: Reactome:R-HSA-6788867
has_obo_namespace: molecular_function
has_exact_synonym: phosphokinase activity
in_subset: goslim chembl
in_subset: goslim drosophila
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim plant
in_subset: goslim yeast
imported from: go.owl

phosphorylation
type: Class
subclass of: GO_0008150
id: GO:0016310
definition: The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
database_cross_reference: Wikipedia:Phosphorylation
has_obo_namespace: biological_process
in_subset: goslim chembl
in_subset: goslim metagenomics
imported from: go.owl

GO_0019077
type: Class
subclass of: GO_0008150
deprecated: true
term replaced by: GO_0044659
IAO_0000231: IAO_0000227
imported from: go.owl

viral genome replication
type: Class
subclass of: GO_0008150
definition: Any process involved directly in viral genome replication, including viral nucleotide metabolism.
id: GO:0019079
has_obo_namespace: biological_process
has_narrow_synonym: sigma virus replication
has_broad_synonym: viral replication
imported from: go.owl

second-messenger-mediated signaling
type: Class
subclass of: GO_0008150
definition: Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell.
id: GO:0019932
has_obo_namespace: biological_process
has_exact_synonym: second messenger mediated signaling
has_exact_synonym: second messenger mediated signalling
has_exact_synonym: second messenger-mediated signaling
has_exact_synonym: second messenger-mediated signalling
has_exact_synonym: second-messenger-mediated signal transduction
has_exact_synonym: second-messenger-mediated signalling
imported from: go.owl

cell cycle phase
type: Class
subclass of: GO_0008150
id: GO:0022403
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
definition: One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
has_obo_namespace: biological_process
in_subset: gocheck do not annotate
imported from: go.owl

signal transduction by protein phosphorylation
type: Class
subclass of: GO_0008150
creation date: 2010-02-16T09:30:50Z
definition: A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate.
id: GO:0023014
has_obo_namespace: biological_process
has_related_synonym: signal transduction via phosphorylation event
has_related_synonym: signal transmission via phosphorylation event
imported from: go.owl

signaling
type: Class
subclass of: GO_0008150
creation date: 2010-02-16T09:30:50Z
has_alternative_id: GO:0023046
id: GO:0023052
has_alternative_id: GO:0044700
comment: Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change.
definition: The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
has_exact_synonym: biological signaling
has_obo_namespace: biological_process
created by: jl
has_exact_synonym: signaling process
has_exact_synonym: signalling
has_related_synonym: signalling process
has_related_synonym: single organism signaling
in_subset: goslim agr
in_subset: goslim flybase ribbon
in_subset: goslim mouse
in_subset: goslim pombe
in_subset: goslim yeast
imported from: go.owl

lamellipodium
type: Class
subclass of: GO_0005575
definition: A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
id: GO:0030027
database_cross_reference: Wikipedia:Lamellipodia
has_obo_namespace: cellular_component
imported from: go.owl

platelet activation
type: Class
subclass of: GO_0008150
definition: A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
id: GO:0030168
has_obo_namespace: biological_process
has_exact_synonym: blood coagulation, platelet activation
imported from: go.owl

regulation of cell migration
type: Class
subclass of: GO_0008150
definition: Any process that modulates the frequency, rate or extent of cell migration.
id: GO:0030334
has_obo_namespace: biological_process
imported from: go.owl

axon
type: Class
subclass of: GO_0005575
id: GO:0030424
database_cross_reference: NIF_Subcellular:sao1770195789
definition: The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
database_cross_reference: Wikipedia:Axon
has_obo_namespace: cellular_component
imported from: go.owl

regeneration
type: Class
subclass of: GO_0008150
id: GO:0031099
definition: The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass).
database_cross_reference: Wikipedia:Regeneration_(biology)
has_obo_namespace: biological_process
imported from: go.owl

neuron projection regeneration
type: Class
subclass of: GO_0008150
id: GO:0031102
definition: The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage.
has_obo_namespace: biological_process
has_narrow_synonym: neurite regeneration
imported from: go.owl

neuron projection development
type: Class
subclass of: neuron development
id: GO:0031175
definition: The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
has_obo_namespace: biological_process
has_narrow_synonym: neurite biosynthesis
has_narrow_synonym: neurite development
has_narrow_synonym: neurite formation
has_narrow_synonym: neurite growth
has_narrow_synonym: neurite outgrowth
imported from: go.owl

adrenergic receptor binding
type: Class
subclass of: signaling receptor binding
id: GO:0031690
definition: Interacting selectively and non-covalently with an adrenergic receptor.
has_narrow_synonym: adrenergic receptor ligand
has_obo_namespace: molecular_function
imported from: go.owl

D1 dopamine receptor binding
type: Class
subclass of: signaling receptor binding
has_narrow_synonym: D1 dopamine receptor ligand
has_exact_synonym: D1A dopamine receptor binding
id: GO:0031748
definition: Interacting selectively and non-covalently with a D1 dopamine receptor.
has_obo_namespace: molecular_function
imported from: go.owl

D5 dopamine receptor binding
type: Class
subclass of: signaling receptor binding
has_exact_synonym: D1B dopamine receptor binding
has_narrow_synonym: D5 dopamine receptor ligand
id: GO:0031752
definition: Interacting selectively and non-covalently with a D5 dopamine receptor.
has_obo_namespace: molecular_function
imported from: go.owl

bleb
type: Class
subclass of: GO_0005575
definition: A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.
id: GO:0032059
database_cross_reference: Wikipedia:Bleb_(cell_biology)
has_obo_namespace: cellular_component
has_exact_synonym: plasma membrane bleb
in_subset: goslim pir
imported from: go.owl

production of miRNAs involved in gene silencing by miRNA
type: Class
subclass of: GO_0008150
definition: Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein, or by increasing the degradation of non-protein-coding RNA transcripts.
has_alternative_id: GO:0030918
id: GO:0035196
has_obo_namespace: biological_process
has_exact_synonym: gene silencing by miRNA, production of miRNAs
has_related_synonym: miRNA biogenesis
has_exact_synonym: miRNA processing
has_exact_synonym: miRNA-mediated gene silencing, production of miRNAs
has_related_synonym: microRNA biogenesis
has_related_synonym: microRNA biosynthesis
has_related_synonym: microRNA biosynthetic process
has_related_synonym: microRNA metabolic process
has_related_synonym: microRNA metabolism
has_broad_synonym: microRNA processing
has_exact_synonym: microRNA-mediated gene silencing, production of microRNAs
has_exact_synonym: production of microRNAs involved in gene silencing by microRNA
imported from: go.owl

phenotypic switching
type: Class
subclass of: GO_0008150
creation date: 2012-03-27T01:31:28Z
definition: A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
id: GO:0036166
comment: Mating type switching is not considered a type of phenotypic switching: for mating type switching, consider instead annotating to 'mating type switching ; GO:0007533'.
created by: bf
has_obo_namespace: biological_process
has_related_synonym: phenotypic dimorphism
imported from: go.owl

regulation of gene expression, epigenetic
type: Class
subclass of: GO_0008150
definition: Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence.
id: GO:0040029
has_obo_namespace: biological_process
in_subset: goslim plant
imported from: go.owl

GO_0042348
type: Class
subclass of: GO_0008150
deprecated: true
term replaced by: GO_1901222
IAO_0000231: IAO_0000227
imported from: go.owl

regulation of membrane potential
type: Class
subclass of: GO_0008150
definition: Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
id: GO:0042391
has_obo_namespace: biological_process
imported from: go.owl

response to drug
type: Class
subclass of: GO_0008150
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
has_alternative_id: GO:0017035
id: GO:0042493
has_obo_namespace: biological_process
has_related_synonym: drug resistance
has_related_synonym: drug susceptibility/resistance
in_subset: goslim candida
imported from: go.owl

biofilm formation
type: Class
subclass of: GO_0008150
definition: A process in which planktonically growing microorganisms grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
id: GO:0042710
has_obo_namespace: biological_process
term tracker item: https://github.com/geneontology/go-ontology/issues/17727
in_subset: gocheck do not annotate
in_subset: gocheck do not manually annotate
in_subset: goslim candida
in_subset: goslim pir
imported from: go.owl

obsolete transcription factor import into nucleus
type: Class
subclass of: protein import into nucleus
consider: GO:0006606
id: GO:0042991
definition: OBSOLETE. The directed movement of a transcription factor from the cytoplasm to the nucleus.
comment: The reason for obsoletion is that there is no distinct pathway to import transcription factors into the nucleus.
has_obo_namespace: biological_process
has_exact_synonym: transcription factor import into cell nucleus
has_exact_synonym: transcription factor transport from cytoplasm to nucleus
has_exact_synonym: transcription factor-nucleus import
deprecated: true
imported from: go.owl

neuron projection
type: Class
subclass of: GO_0005575
definition: A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
id: GO:0043005
database_cross_reference: NIF_Subcellular:sao867568886
has_obo_namespace: cellular_component
has_related_synonym: nerve fiber
has_narrow_synonym: neurite
has_exact_synonym: neuron process
has_exact_synonym: neuron protrusion
has_exact_synonym: neuronal cell projection
in_subset: goslim pir
imported from: go.owl

negative regulation of catalytic activity
type: Class
subclass of: GO_0008150
definition: Any process that stops or reduces the activity of an enzyme.
id: GO:0043086
has_alternative_id: GO:0048553
has_obo_namespace: biological_process
has_exact_synonym: down regulation of enzyme activity
has_narrow_synonym: down regulation of metalloenzyme activity
has_exact_synonym: down-regulation of enzyme activity
has_exact_synonym: down-regulation of metalloenzyme activity
has_exact_synonym: downregulation of enzyme activity
has_narrow_synonym: downregulation of metalloenzyme activity
has_narrow_synonym: inhibition of enzyme activity
has_narrow_synonym: inhibition of metalloenzyme activity
has_exact_synonym: negative regulation of enzyme activity
has_narrow_synonym: negative regulation of metalloenzyme activity
imported from: go.owl

regulation of RNA splicing
type: Class
subclass of: GO_0008150
definition: Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
id: GO:0043484
has_obo_namespace: biological_process
imported from: go.owl

protein kinase B signaling
type: Class
subclass of: GO_0008150
definition: A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound.
has_exact_synonym: AKT signal transduction
has_exact_synonym: AKT signaling
has_related_synonym: AKT signaling cascade
has_exact_synonym: AKT signalling cascade
id: GO:0043491
has_exact_synonym: PKB signal transduction
has_exact_synonym: PKB signaling
has_related_synonym: PKB signaling cascade
has_related_synonym: PKB signalling cascade
has_obo_namespace: biological_process
has_exact_synonym: protein kinase B signal transduction
has_related_synonym: protein kinase B signaling cascade
has_related_synonym: protein kinase B signalling cascade
imported from: go.owl

cell body
type: Class
subclass of: GO_0005575
creation date: 2010-02-05T10:37:16Z
database_cross_reference: FBbt:00005107
database_cross_reference: FMA:67301
id: GO:0044297
comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections.
definition: The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
database_cross_reference: Wikipedia:Cell_body
has_exact_synonym: cell soma
has_obo_namespace: cellular_component
created by: jl
imported from: go.owl

axon collateral
type: Class
subclass of: GO_0005575
creation date: 2010-02-05T11:29:04Z
definition: Any of the smaller branches of an axon that emanate from the main axon cylinder.
id: GO:0044303
database_cross_reference: NIF_Subcellular:sao1470140754
has_obo_namespace: cellular_component
created by: jl
imported from: go.owl

dendritic branch
type: Class
subclass of: GO_0005575
creation date: 2010-02-05T04:18:53Z
definition: A dendrite arising from another dendrite.
id: GO:0044307
database_cross_reference: NIF_Subcellular:sao884265541
has_obo_namespace: cellular_component
has_exact_synonym: dendrite branch
created by: jl
has_narrow_synonym: secondary dendrite
imported from: go.owl

GO_0045449
type: Class
subclass of: GO_0008150
deprecated: true
term replaced by: regulation of transcription, DNA-templated
IAO_0000231: IAO_0000227
imported from: go.owl

negative regulation of membrane potential
type: Class
subclass of: regulation of membrane potential
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
id: GO:0045837
has_obo_namespace: biological_process
has_exact_synonym: down regulation of membrane potential
has_exact_synonym: down-regulation of membrane potential
has_exact_synonym: downregulation of membrane potential
has_narrow_synonym: inhibition of membrane potential
has_exact_synonym: reduction of membrane potential
imported from: go.owl

positive regulation of membrane potential
type: Class
subclass of: regulation of membrane potential
definition: Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
id: GO:0045838
has_narrow_synonym: activation of membrane potential
has_obo_namespace: biological_process
has_exact_synonym: elevation of membrane potential
has_narrow_synonym: stimulation of membrane potential
has_exact_synonym: up regulation of membrane potential
has_exact_synonym: up-regulation of membrane potential
has_exact_synonym: upregulation of membrane potential
imported from: go.owl

viral entry into host cell
type: Class
subclass of: GO_0008150
has_alternative_id: GO:0019063
id: GO:0046718
definition: The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
database_cross_reference: VZ:936
comment: Viral attachment to the host cell is not part of viral entry in GO because virus attachment does not always lead to viral entry: attachment can also result in the virion being carried by the host cell to another location.
has_obo_namespace: biological_process
has_exact_synonym: entry of virus into host cell
has_exact_synonym: phage translocation
has_exact_synonym: viral penetration
has_exact_synonym: virion penetration
has_exact_synonym: virion penetration into host cell
has_exact_synonym: virus entry into host cell
in_subset: goslim metagenomics
imported from: go.owl

neuron development
type: Class
subclass of: GO_0008150
id: GO:0048666
definition: The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
has_obo_namespace: biological_process
imported from: go.owl

neuron projection morphogenesis
type: Class
subclass of: GO_0008150
id: GO:0048812
definition: The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
has_obo_namespace: biological_process
has_narrow_synonym: neurite biosynthesis
has_narrow_synonym: neurite formation
has_narrow_synonym: neurite growth
has_related_synonym: neurite morphogenesis
imported from: go.owl

GO_0050663
type: Class
subclass of: GO_0003674
deprecated: true
term replaced by: cytokine production
IAO_0000231: IAO_0000227
imported from: go.owl

regulation of catalytic activity
type: Class
subclass of: GO_0008150
definition: Any process that modulates the activity of an enzyme.
has_alternative_id: GO:0048552
id: GO:0050790
has_obo_namespace: biological_process
has_exact_synonym: regulation of enzyme activity
has_narrow_synonym: regulation of metalloenzyme activity
in_subset: goslim chembl
imported from: go.owl

protein stabilization
type: Class
subclass of: GO_0008150
definition: Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
id: GO:0050821
has_obo_namespace: biological_process
has_narrow_synonym: lysosomal protein stabilization
has_exact_synonym: positive regulation of protein stability
has_related_synonym: protein sequestering
has_exact_synonym: protein stabilisation
has_related_synonym: protein stabilization activity
in_subset: goslim chembl
imported from: go.owl

regulation of DNA-binding transcription factor activity
type: Class
subclass of: GO_0008150
definition: Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
id: GO:0051090
has_alternative_id: GO:1904167
has_alternative_id: GO:2000823
has_obo_namespace: biological_process
has_exact_synonym: regulation of DNA binding transcription factor activity
has_narrow_synonym: regulation of androgen receptor activity
has_exact_synonym: regulation of sequence-specific DNA binding transcription factor activity
has_narrow_synonym: regulation of thyroid hormone receptor activity
has_broad_synonym: regulation of transcription factor activity
imported from: go.owl

G1 phase
type: Class
subclass of: cell cycle phase
id: GO:0051318
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
definition: The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis.
database_cross_reference: Wikipedia:G1_phase
has_obo_namespace: biological_process
in_subset: gocheck do not annotate
imported from: go.owl

G2 phase
type: Class
subclass of: cell cycle phase
id: GO:0051319
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
definition: The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis).
database_cross_reference: Wikipedia:G2_phase
has_obo_namespace: biological_process
in_subset: gocheck do not annotate
imported from: go.owl

S phase
type: Class
subclass of: cell cycle phase
id: GO:0051320
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
has_exact_synonym: S-phase
definition: The cell cycle phase, following G1, during which DNA synthesis takes place.
database_cross_reference: Wikipedia:S_phase
has_obo_namespace: biological_process
in_subset: gocheck do not annotate
imported from: go.owl

meiotic cell cycle
type: Class
subclass of: cell cycle
has_alternative_id: GO:0007126
id: GO:0051321
comment: Note that this term should not be confused with 'GO:0140013 ; meiotic nuclear division'. 'GO:0051321 ; meiotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140013 meiotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle.
definition: Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
database_cross_reference: Wikipedia:Meiosis
has_obo_namespace: biological_process
has_related_synonym: meiosis
in_subset: goslim drosophila
in_subset: goslim yeast
imported from: go.owl

meiotic M phase
type: Class
subclass of: M phase
definition: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a meiotic cell cycle.
id: GO:0051327
has_exact_synonym: M phase of meiotic cell cycle
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
has_obo_namespace: biological_process
in_subset: gocheck do not annotate
imported from: go.owl

meiotic G1 phase
type: Class
subclass of: G1 phase
has_exact_synonym: G1 phase of meiotic cell cycle
id: GO:0051330
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
definition: The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by meiosis and the beginning of DNA synthesis.
has_obo_namespace: biological_process
in_subset: gocheck do not annotate
imported from: go.owl

meiotic G2 phase
type: Class
subclass of: G2 phase
has_exact_synonym: G2 phase of meiotic cell cycle
id: GO:0051331
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
definition: The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by meiosis.
has_obo_namespace: biological_process
in_subset: gocheck do not annotate
imported from: go.owl

meiotic S phase
type: Class
subclass of: S phase
id: GO:0051332
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
has_exact_synonym: S phase of meiotic cell cycle
has_exact_synonym: S-phase of meiotic cell cycle
definition: The cell cycle phase, following G1, during which DNA synthesis takes place as part of a meiotic cell cycle.
has_obo_namespace: biological_process
in_subset: gocheck do not annotate
imported from: go.owl

regulation of ubiquitin-protein transferase activity
type: Class
subclass of: GO_0008150
has_narrow_synonym: APC regulator
definition: Any process that modulates the frequency, rate or extent of ubiquitin transferase activity.
id: GO:0051438
has_narrow_synonym: SCF complex regulator
has_narrow_synonym: anaphase-promoting complex regulator
has_obo_namespace: biological_process
has_exact_synonym: regulation of ubiquitin transferase activity
has_related_synonym: ubiquitin transferase regulator
has_related_synonym: ubiquitin-protein transferase regulator
imported from: go.owl

protein C-terminal methylesterase activity
type: Class
subclass of: GO_0008150
definition: Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol.
id: GO:0051722
database_cross_reference: Reactome:R-HSA-8856951
has_obo_namespace: molecular_function
has_narrow_synonym: protein phosphatase methylesterase activity
imported from: go.owl

regulation of mitochondrial membrane potential
type: Class
subclass of: regulation of membrane potential
definition: Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
id: GO:0051881
has_obo_namespace: biological_process
imported from: go.owl

regulation of gene silencing by miRNA
type: Class
subclass of: GO_0008150
creation date: 2009-10-05T03:10:28Z
definition: Any process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: RNA (often mRNA) cleavage or mRNA translational repression.
id: GO:0060964
has_obo_namespace: biological_process
created by: dph
has_exact_synonym: regulation of gene silencing by microRNA
imported from: go.owl

regulation of proteasomal protein catabolic process
type: Class
subclass of: GO_0008150
creation date: 2010-05-17T01:33:20Z
definition: Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
id: GO:0061136
has_obo_namespace: biological_process
created by: dph
imported from: go.owl

regulation of molecular function
type: Class
subclass of: GO_0008150
definition: Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
id: GO:0065009
has_obo_namespace: biological_process
has_exact_synonym: regulation of a molecular function
in_subset: gocheck do not annotate
in_subset: goslim pir
in_subset: goslim plant
imported from: go.owl

necrotic cell death
type: Class
subclass of: GO_0008150
definition: A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues.
id: GO:0070265
comment: Note that the word necrosis has been widely used in earlier literature to describe forms of cell death which are now known by more precise terms, such as apoptosis. Necrosis can occur in a regulated fashion, involving a precise sequence of signals; in this case, consider annotating to GO:0097300 'programmed necrotic cell death' or to its more specific child GO:0070266 'necroptotic process'.
has_obo_namespace: biological_process
has_exact_synonym: cellular necrosis
has_broad_synonym: necrosis
imported from: go.owl

protein kinase C signaling
type: Class
subclass of: GO_0008150
definition: A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
id: GO:0070528
has_exact_synonym: PKC signal transduction
has_related_synonym: PKC signaling cascade
has_obo_namespace: biological_process
has_exact_synonym: protein kinase C signal transduction
has_related_synonym: protein kinase C signaling cascade
has_related_synonym: protein kinase C signalling cascade
imported from: go.owl

ER-associated misfolded protein catabolic process
type: Class
subclass of: GO_0008150
creation date: 2010-03-10T12:53:27Z
has_exact_synonym: ER-associated misfolded protein breakdown
has_exact_synonym: ER-associated misfolded protein catabolism
has_exact_synonym: ER-associated misfolded protein degradation
id: GO:0071712
comment: See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'.
definition: The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.
has_obo_namespace: biological_process
has_exact_synonym: endoplasmic reticulum-associated misfolded protein catabolic process
has_exact_synonym: endoplasmic reticulum-associated misfolded protein catabolism
created by: mah
has_exact_synonym: proteasomal protein catabolism of misfolded ER proteins
imported from: go.owl

establishment of cell polarity regulating cell shape
type: Class
subclass of: GO_0008150
creation date: 2011-06-22T03:10:08Z
definition: Any cellular process that results in the specification or formation of a polarized intracellular organization or cell growth pattern that regulates the shape of a cell.
id: GO:0071964
has_obo_namespace: biological_process
created by: mah
imported from: go.owl

axon microtubule bundle
type: Class
subclass of: GO_0005575
creation date: 2012-11-07T15:37:12Z
definition: An arrangement of closely apposed microtubules running parallel to each other in the axon hillock and initial segment.
id: GO:1901589
database_cross_reference: NIF_Subcellular:sao707332678
has_exact_synonym: axon microtubule fascicle
has_obo_namespace: cellular_component
has_exact_synonym: microtubule bundle of axon
has_exact_synonym: microtubule fascicle of axon
created by: pr
imported from: go.owl