alternative term
type: AnnotationProperty
textual definition: An alternative name for a class or property which means the same thing as the preferred name (semantically equivalent)
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
term editor: PERSON:Daniel Schober
editor preferred label: alternative term
has curation status: IAO_0000125

term editor
type: AnnotationProperty
editor note: 20110707, MC: label update to term editor and definition modified accordingly. See http://code.google.com/p/information-artifact-ontology/issues/detail?id=115.
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
textual definition: Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people
term editor: PERSON:Daniel Schober
editor preferred label: term editor
has curation status: IAO_0000122

definition source
type: AnnotationProperty
definition source: Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
term editor: PERSON:Daniel Schober
editor preferred label: definition source
textual definition: formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007
has curation status: IAO_0000122

rdfs:isDefinedBy
type: AnnotationProperty
textual definition: Is defined by.

has curation status
type: AnnotationProperty
definition source: OBI_0000281
term editor: PERSON:Alan Ruttenberg
term editor: PERSON:Bill Bug
term editor: PERSON:Melanie Courtot
editor preferred label: has curation status

editor note
type: AnnotationProperty
is metadata tag: true
textual definition: An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology.
has_obo_namespace: uberon
id: editor_note
database_cross_reference: IAO:0000116
definition source: GROUP:OBI:<http://purl.obfoundry.org/obo/obi>
term editor: PERSON:Daniel Schober
editor preferred label: editor note
shorthand: editor_note
has curation status: IAO_0000122

imported from
type: AnnotationProperty
textual definition: For external terms/classes, the ontology from which the term was imported
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
term editor: PERSON:Alan Ruttenberg
term editor: PERSON:Melanie Courtot
editor preferred label: imported from
has curation status: IAO_0000125

see also
type: AnnotationProperty
is metadata tag: true
shorthand: seeAlso
database_cross_reference: seeAlso
id: seeAlso
has_obo_namespace: uberon

textual definition
type: AnnotationProperty
label: definition
editor note: 2012-04-05: Barry Smith The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. Can you fix to something like: A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. Alan Ruttenberg Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. On the specifics of the proposed definition: We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
term editor: PERSON:Daniel Schober
textual definition: The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
textual definition: The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
textual definition: The official definition.
editor preferred label: definition
has curation status: IAO_0000122

database_cross_reference
type: AnnotationProperty
textual definition: Reference database or publication source.

example of usage
type: AnnotationProperty
is metadata tag: true
database_cross_reference: IAO:0000112
shorthand: example_of_usage
id: example_of_usage
has_obo_namespace: uberon
textual definition: A phrase describing how a class name should be used. May also include other kinds of examples that facilitate immediate understanding of a class semantics, such as widely known prototypical subclasses or instances of the class. Although essential for high level terms, examples for low level terms (e.g., Affymetrix HU133 array) are not
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
term editor: PERSON:Daniel Schober
editor preferred label: example
editor preferred label: example of usage
has curation status: IAO_0000122

editor preferred label
type: AnnotationProperty
label: editor preferred term~editor preferred label
label: editor preferred term
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
term editor: PERSON:Daniel Schober
textual definition: The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English)
editor preferred label: editor preferred label
editor preferred label: editor preferred term
has curation status: IAO_0000122

id
type: AnnotationProperty
textual definition: An identifier for an individual entity.
textual definition: An identifier is an information content entity that is the outcome of a dubbing process and is used to refer to one instance of entity shared by a group of people to refer to that individual entity.

comment
type: AnnotationProperty
textual definition: Comment.

LINCS ID
type: AnnotationProperty
textual definition: An annotation property that represents an ID used in the NIH LINCS project.
term editor: Oliver He, Jiangan Xie, Jie Zheng

has_obo_namespace
type: AnnotationProperty
comment: disease_ontology
textual definition: Name space of the ontology.

PubChem AID
type: AnnotationProperty
term editor: Oliver He
definition source: https://pubchem.ncbi.nlm.nih.gov/help.html
textual definition: An annotation property that represents a PubMed BioAssay Identifier accession number.

shorthand
type: AnnotationProperty

label
type: AnnotationProperty
textual definition: A human readable name for this class.

cell line cell
type: Class
subclass of: BAO_0003114
textual definition: A cultured cell that is part of a cell line - a stable and homogeneous population of cells with a common biological origin and propagation history in culture
editor preferred label: cell line cell
term editor: Yongqun He, Matthew Brush, Sirarat Sarntivijai, Alexander Diehl, Jie Zheng, Yu Lin, Bjoern Peters
comment: A 'cell line cell' is a part of a cell line established through the passaging/selection of a primary cultured cells or the experimental modification of an existing cell line. New types of cell line cells are established after sufficient passaging of a primary culture to establish a stable and homogenous population that qualifies as a line (typically 1-20 passages), or following some spontaneous or experimental modification that confers novel characteristics to an existing line. A cell line cell typically has mutations of five or more genes compared to the original cell that derives the cell line cell. Some gene mutations may turn on some oncogenes. Cell line cells can be in active culture, stored in a quiescent state for future use (e.g. frozen in liquid nitrogen), or applied in experimental procedures.
imported from: clo.owl
imported from: obi.owl

immortal cell line cell
type: Class
subclass of: cell line cell
editor preferred label: immortal cell line cell
term editor: Yongqun He, Matthew Brush, Allen Xiang, Asiyah Yu Lin, Sirarat Sarntivijai, James Malone, Jie Zheng, Tomasz Adamusiak
alternative term: continuous cell line cell
textual definition: A cell line cell that is expected to be capable of an unlimited number of divisions, and is thus able to support indefinite propagation in vitro as part of an immortal cell line.
alternative term: permanent cell line cell
imported from: clo.owl
imported from: obi.owl

cell line
type: Class
subclass of: BAO_0003114
example of usage: He, Tong-Chuan, et al., Identification of c-MYC as a target of the APC pathway. Science 281.5382 (1998): 1509-1512.: "To evaluate the transcriptional effects of APC, we studied a human colorectal cancer cell line (HT29-APC) containing a zinc-inducible APC gene and a control cell line (HT29–β-Gal) containing an analogous inducible lacZ gene". Note that common usage in the literature is often of the form "a human colorectal cancer cell line", as seen above. But such references to studies in "a line" refer to the fact that discrete populations of cells that are input into culturing or experiments, not an entire lineage of cells. It is these discrete populations that we refer to as 'cell lines'.
textual definition: A cultured cell population that represents a genetically stable and homogenous population of cultured cells that shares a common propagation history (i.e. has been successively passaged together in culture).
term editor: MB, SS, JZ, MAH, BP, CS, YH
editor note: In the spring of 2013, a working group comprised of domain experts and representatives from CLO, OBI, CL, and ReO worked to establish a consensus model and definitions of cultured cells across these efforts. This included a careful characterization of how the term 'cell line' should be defined and applied. Notes about this work and its outcomes can be found on the CLO wiki here: http://code.google.com/p/clo-ontology/wiki/Cell_Lines
comment: The term 'line' is used when a culture has undergone an intentional experimental process to establish a more uniform and stable population of cells (see 'establishing cell line'). This will require one or more passages, but may involve additional selection processes. Through such passaging and/or selection processes, the resulting 'line' attains some level of genetic stability and compositional homogeneity which is typically absent in primary cultures. Because of their relative homogeneity, ‘lines’ are capable of being characterized and stably propagated over a period of time. A new *type* of cell line can be established not only through the passaging/selection of a primary culture, but also through experimental modifications of existing lines (e.g. immortalization, stable genetic modifications, drug selection for a resistant subset, etc.). The definition provided here establishes the 'scale' of cell populations that qualify as cell lines - specifically those with a shared propagation history in culture. In this way, the 'cell line' class demarcates populations that represent what researchers actually use in the practice of science - e.g. as inputs to culturing, experimentation, and sharing. The definition is such that cell lines will exhibit important attributes. For example, they will have a relatively homogenous cell type composition as they have experienced similar selective pressures due to their continuous co-propagation. In addition, these populations can also be characterized by a passage number, again owing to their common passaging history. As defined here, 'cell line' can refer to a population of cells in active culture, applied experimentally, or stored in a quiescent state for future use.
editor preferred label: cell line
imported from: clo.owl
imported from: obi.owl

697 cell
type: Class
subclass of: immortal cell line cell
see also: CVCL: CVCL_0079
see also: CHEMBL: CHEMBL3308147
see also: HyperCLDB: cl117
LINCS ID: LCL-1042
alternative term: 697
see also: Sanger: COSMIC ID:906800
imported from: clo.owl

HEK293
type: Class
subclass of: immortal cell line cell
alternative term: 293 HEK
definition source: WEB: http://web.expasy.org/cellosaurus/CVCL_0045
definition source: WEB: https://www.atcc.org/Products/All/CRL-1573.aspx
alternative term: 293
alternative term: HEK 293
definition source: WEB: http://hek293.com/
see also: RRID: CVCL_0045
see also: ATCC: CRL-1573
alternative term: 293 cell
see also: BTO: BTO_0000007
see also: EFO: EFO_0001182)
alternative term: HEK-293
alternative term: Human Embryonic Kidney 293
imported from: clo.owl

293T/17 cell
type: Class
subclass of: immortal cell line cell
see also: ATCC: CRL-11268
alternative term: 293T/17
definition source: WEB: https://www.atcc.org/Products/All/CRL-11268.aspx
imported from: clo.owl

A549 cell
type: Class
subclass of: immortal cell line cell
see also: CVCL: CVCL_0023
see also: HyperCLDB: cl207
see also: CHEMBL: CHEMBL3307651
see also: EFO: EFO_0001086
alternative term: A549
see also: ATCC: CCL-185
LINCS ID: LCL-1601
imported from: clo.owl

ACHN cell
type: Class
subclass of: immortal cell line cell
see also: CVCL: CVCL_1067
LINCS ID: LCL-1756
see also: CHEMBL: CHEMBL3307633
alternative term: ACHN
see also: ATCC: CRL-1611
see also: EFO: EFO_0002108
imported from: clo.owl

AML12 cell
type: Class
subclass of: immortal cell line cell
see also: ATCC: CRL-2254
alternative term: AML12
imported from: clo.owl

BA/F3 cell
type: Class
subclass of: immortal cell line cell
alternative term: BA/F3
see also: HyperCLDB: cl5028
imported from: clo.owl

BT-549 cell
type: Class
subclass of: immortal cell line cell
see also: ATCC: HTB-122
comment: disease: ductal carcinoma
LINCS ID: LCL-1310
alternative term: BT-549
see also: CVCL: CVCL_1092
see also: EFO: EFO_0001096
see also: CHEMBL: CHEMBL3308490
imported from: clo.owl

C-33 A cell
type: Class
subclass of: immortal cell line cell
see also: ATCC: HTB-31
LINCS ID: LCL-1300
alternative term: C-33 A
imported from: clo.owl

Caco-2 cell
type: Class
subclass of: immortal cell line cell
see also: MeSH: D018938
see also: EFO: EFO_0001099
see also: CVCL: CVCL_0025
see also: CHEMBL: CHEMBL3307519
see also: ATCC: HTB-37
alternative term: Caco-2
see also: HyperCLDB: cl618
LINCS ID: LCL-1170
comment: disease: colorectal adenocarcinoma
imported from: clo.owl

CAKI-1 cell
type: Class
subclass of: immortal cell line cell
alternative term: CAKI-1
see also: HyperCLDB: cl623
imported from: clo.owl

Caki-1 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1774
comment: disease: clear cell carcinoma (kidney primary)
see also: CVCL: CVCL_0234
see also: EFO: EFO_0002149
see also: CHEMBL: CHEMBL3307522
alternative term: Caki-1
see also: ATCC: HTB-46
imported from: clo.owl

Calu-1 cell
type: Class
subclass of: immortal cell line cell
see also: HyperCLDB: cl632
see also: HyperCLDB: cl631
see also: CHEMBL: CHEMBL3308031
alternative term: Calu-1
LINCS ID: LCL-1580
see also: EFO: EFO_0002151
see also: ATCC: HTB-54
term editor: ZN
see also: CVCL: CVCL_0608
comment: disease: epidermoid carcinoma (lung primary)
imported from: clo.owl

CCRF-CEM cell
type: Class
subclass of: immortal cell line cell
alternative term: CCRF-CEM
see also: EFO: EFO_0002128
see also: CVCL: CVCL_0207
see also: ATCC: CCL-119
LINCS ID: LCL-1012
see also: CHEMBL: CHEMBL3307641
imported from: clo.owl

CHL-1 cell
type: Class
subclass of: immortal cell line cell
alternative term: CHL-1
see also: ATCC: CRL-9446
imported from: clo.owl

CHO cell
type: Class
subclass of: immortal cell line cell
see also: MeSH: D016466
see also: HyperCLDB: cl721
alternative term: CHO
alternative term: Chinese Hamster Ovary cell
imported from: clo.owl

CHO-K1 cell
type: Class
subclass of: immortal cell line cell
alternative term: CHO-K1
see also: ATCC: CCL-61
imported from: clo.owl

COLO 205 cell
type: Class
subclass of: immortal cell line cell
comment: disease: colorectal adenocarcinoma (colon primary)
LINCS ID: LCL-1173
see also: CHEMBL: CHEMBL3308348
see also: ATCC: CCL-222
alternative term: COLO 205
see also: CVCL: CVCL_0218
see also: EFO: EFO_0003082
see also: ECACC: 87061208
imported from: clo.owl

COS-7 cell
type: Class
subclass of: immortal cell line cell
see also: ATCC: CRL-1651
see also: MeSH: D019556
alternative term: COS-7
imported from: clo.owl

DLD-1 cell
type: Class
subclass of: immortal cell line cell
comment: disease: colorectal adenocarcinoma
see also: ATCC: CCL-221
see also: CHEMBL: CHEMBL3307580
alternative term: DLD-1
see also: CVCL: CVCL_0248
LINCS ID: LCL-1175
imported from: clo.owl

DU 145 cell
type: Class
subclass of: immortal cell line cell
comment: disease: carcinoma (prostate primary)
LINCS ID: LCL-1146
see also: ATCC: HTB-81
alternative term: DU 145
imported from: clo.owl

H-4-II-E cell
type: Class
subclass of: immortal cell line cell
comment: disease: hepatoma
alternative term: H-4-II-E
see also: ATCC: CRL-1548
imported from: clo.owl

H69AR cell
type: Class
subclass of: immortal cell line cell
see also: ATCC: CRL-11351
alternative term: H69AR
comment: disease: carcinoma; small cell lung cancer; multidrug resistant
imported from: clo.owl

HCT 116 cell
type: Class
subclass of: immortal cell line cell
see also: MeSH: D045325
see also: ECACC: 91091005
alternative term: HCT-116
LINCS ID: LCL-1161
alternative term: HCT116
see also: ATCC: CCL-247
textual definition: immortal human epithelial cell line cell that was derived from some colon epithelial cell from a human patient with the disease colon carcinoma
alternative term: HCT 116
definition source: WEB: https://www.atcc.org/products/all/CCL-247.aspx
comment: disease: colorectal carcinoma
definition source: WEB: http://web.expasy.org/cellosaurus/CVCL_0291
see also: HyperCLDB: cl1575
imported from: clo.owl

HEL cell
type: Class
subclass of: immortal cell line cell
see also: HyperCLDB: cl1585
see also: DSMZ: ACC 11
see also: CVCL: CVCL_0001
LINCS ID: LCL-1053
alternative term: HEL
see also: CHEMBL: CHEMBL3308090
imported from: clo.owl

HeLa cell
type: Class
subclass of: immortal cell line cell
see also: CHEMBL: CHEMBL3308376
definition source: WEB: http://www.atcc.org/products/all/CCL-2.aspx
see also: ATCC: CCL-2
definition source: WEB: http://en.wikipedia.org/wiki/HeLa
LINCS ID: LCL-1512
see also: HyperCLDB: cl1601
definition source: WEB: https://www.ncbi.nlm.nih.gov/pubmed/12001993
see also: MeSH: D006367
textual definition: an immortal human uterine cervix-derived epithelial cell line that was derived from cervical adenocarcinoma cancer cells taken on February 8, 1951 from Henrietta Lacks, a patient who died of her cancer on October 4, 1951.
see also: EFO: EFO_0001185
alternative term: HeLa
imported from: clo.owl

Hep G2 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1925
see also: HyperCLDB: cl1644
alternative term: Hep G2
alternative term: HEPG2
alternative term: HEP-G2
see also: ATCC: HB-8065
definition source: WEB: https://www.atcc.org/products/all/HB-8065.aspx
alternative term: HEP G2
definition source: WEB: http://web.expasy.org/cellosaurus/CVCL_0027
definition source: WEB: https://en.wikipedia.org/wiki/Hep_G2
alternative term: HepG2
imported from: clo.owl

HL-60 cell
type: Class
subclass of: immortal cell line cell
see also: CHEMBL: CHEMBL3307654
see also: ATCC: CCL-240
see also: HyperCLDB: cl1684
see also: HyperCLDB: cl1689
alternative term: HL-60
comment: disease: promyeloblast; acute promyelocytic leukemia
see also: CVCL: CVCL_0002
see also: EFO: EFO_0002793
see also: MeSH: D018922
LINCS ID: LCL-1054
imported from: clo.owl

Hs 578T cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1315
alternative term: HS578T
comment: disease: ductal carcinoma
alternative term: Hs 578T
see also: ATCC: HTB-126
imported from: clo.owl

HT-1080 cell
type: Class
subclass of: immortal cell line cell
see also: ATCC: CCL-121
comment: disease: fibrosarcoma
alternative term: HT-1080
imported from: clo.owl

HT-29 cell
type: Class
subclass of: immortal cell line cell
alternative term: HT-29
see also: CVCL: CVCL_0320
LINCS ID: LCL-1180
comment: disease: colorectal adenocarcinoma
see also: MeSH: D019073
see also: CHEMBL: CHEMBL3307768
see also: EFO: EFO_0001193
alternative term: HT29
see also: HyperCLDB: cl1752
see also: ATCC: HTB-38
imported from: clo.owl

HUV-EC-C cell
type: Class
subclass of: immortal cell line cell
alternative term: HUV-EC-C
see also: ATCC: CRL-1730
alternative term: HUVEC
definition source: WEB: https://www.atcc.org/Products/All/CRL-1730.aspx
imported from: clo.owl

IEC-6 cell
type: Class
subclass of: immortal cell line cell
see also: HyperCLDB: cl1802
alternative term: IEC-6
see also: ATCC: CRL-1592
comment: disease: epithelium
imported from: clo.owl

JURKAT cell
type: Class
subclass of: immortal cell line cell
definition source: WEB: https://en.wikipedia.org/wiki/Jurkat_cells
comment: disease: leukemia, T cell
textual definition: an immortalized human T lymphocyte cell that was derived in the late 1970s from the peripheral blood of a 14-year-old boy with T cell leukemia
see also: RRID: CVCL_0065
see also: HyperCLDB: cl5296
alternative term: JURKAT
see also: MeSH: D019169
imported from: clo.owl

L6 cell
type: Class
subclass of: immortal cell line cell
see also: ATCC: CRL-1458
alternative term: L6
imported from: clo.owl

LLC-PK subscript(1) cell
type: Class
subclass of: immortal cell line cell
see also: MeSH: D018374
alternative term: LLC-PK subscript(1)
see also: HyperCLDB: cl3221
see also: ATCC: CL-101
imported from: clo.owl

MCF7 cell
type: Class
subclass of: immortal cell line cell
alternative term: MCF 7 cell
see also: RRID: CVCL_0031
alternative term: MCF-7 cell
textual definition: an immortal breast cancer cell line cell isolated in 1970 from a 69-year-old Caucasian woman.
alternative term: MCF7
see also: HyperCLDB: cl3372
definition source: WEB: https://en.wikipedia.org/wiki/MCF-7
see also: CHEMBL: CHEMBL3308403
see also: ATCC: HTB-22
see also: HyperCLDB: cl3366
see also: EFO: EFO_0002082
LINCS ID: LCL-1460
definition source: WEB: http://web.expasy.org/cellosaurus/CVCL_0031
comment: disease: adenocarcinoma (mammary gland primary)
term editor: ZN
imported from: clo.owl

MDA-MB-231 cell
type: Class
subclass of: immortal cell line cell
see also: ATCC: HTB-26
alternative term: MDA-MB-231
textual definition: an immortal breast cancer cell line cell derived from a human patient with breast adenocarcinoma
see also: EFO: EFO_0001209
term editor: ZN, YH
see also: CHEMBL: CHEMBL3307960
LINCS ID: LCL-1461
see also: RRID: CVCL_0062
imported from: clo.owl

MDCK cell
type: Class
subclass of: immortal cell line cell
see also: HyperCLDB: cl5078
alternative term: MDCK
textual definition: A model mammalian cell line cell that was genereated from the initial isolation in 1958 of epithelial cells from the kidney tubule of an adult Cocker Spaniel dog by Stewart H. Madin and Norman B. Darby, Jr..
definition source: https://en.wikipedia.org/wiki/Madin-Darby_canine_kidney_cells
alternative term: Madin-Darby canine kidney cell
imported from: clo.owl

ME-180 cell
type: Class
subclass of: immortal cell line cell
see also: ATCC: HTB-33
comment: disease: epidermoid carcinoma (cervix primary)
see also: CVCL: CVCL_1401
alternative term: ME-180
LINCS ID: LCL-1305
see also: CHEMBL: CHEMBL3308114
imported from: clo.owl

MRC-5 cell
type: Class
subclass of: immortal cell line cell
see also: HyperCLDB: cl3564
see also: ATCC: CCL-171
alternative term: MRC-5
imported from: clo.owl

Mv 1 Lu cell
type: Class
subclass of: immortal cell line cell
see also: HyperCLDB: cl3604
alternative term: Mv 1 Lu
see also: HyperCLDB: cl3609
see also: HyperCLDB: cl3608
imported from: clo.owl

NIH-3T3 cell
type: Class
subclass of: immortal cell line cell
see also: ATCC: CRL-1658
see also: MeSH: D041681
alternative term: NIH-3T3
see also: HyperCLDB: cl3711
see also: HyperCLDB: cl3710
imported from: clo.owl

SH-SY5Y cell
type: Class
subclass of: immortal cell line cell
alternative term: SH-SY5Y
see also: ATCC: CRL-2266
LINCS ID: LCL-2000
definition source: https://www.atcc.org/en/Products/Cells_and_Microorganisms/By_Tissue/Bone_Marrow/CRL-2266.aspx
alternative term: SHSY5Y
imported from: clo.owl

SK-MEL-5 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1282
see also: ATCC: HTB-70
see also: CHEMBL: CHEMBL3307744
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/3121170
textual definition: A melanoma cell line cell. This cell line was established in 1974 from a metastatic site (axillary lymph node) in a 24-year-old Caucasian female with malignant melanoma, expresses mutant B-Raf (V600E) and wildtype N-Ras.
definition source: WEB: http://web.expasy.org/cellosaurus/CVCL_1706
see also: Sanger: COSMIC ID:905956
see also: CVCL: CVCL_0527
alternative term: SK-MEL-5
definition source: WEB: https://strap.nci.nih.gov/celline_detail.php?sample_id=56
see also: EFO: EFO_0002080
see also: PubChem AID: 488899
imported from: clo.owl

SK-N-SH cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1971
see also: EFO: EFO_0003072
see also: ATCC: HTB-11
alternative term: SK-N-SH
see also: CVCL: CVCL_0531
see also: CHEMBL: CHEMBL3307745
imported from: clo.owl

SW403 cell
type: Class
subclass of: immortal cell line cell
see also: ATCC: CCL-230
alternative term: SW403
see also: RRID: CVCL_0545
see also: PubChem AID: 504653
LINCS ID: LCL-1195
see also: Sanger: COSMIC ID:910908
imported from: clo.owl

THP-1 cell
type: Class
subclass of: immortal cell line cell
see also: ATCC: TIB-202
LINCS ID: LCL-1072
see also: CHEMBL: CHEMBL3307574
see also: EFO: EFO_0001253
alternative term: THP1
see also: HyperCLDB: cl4514
see also: CVCL: CVCL_0006
alternative term: THP-1
imported from: clo.owl

U-2 OS cell
type: Class
subclass of: immortal cell line cell
alternative term: U-2 OS
definition source: WEB: https://www.atcc.org/Products/All/HTB-96.aspx
see also: CHEMBL: CHEMBL3307757
see also: ATCC: HTB-96
see also: EFO: EFO_0002869
LINCS ID: LCL-1431
alternative term: U2OS
see also: CVCL: CVCL_0042
imported from: clo.owl

obsolete: U87 MG cell
type: Class
subclass of: immortal cell line cell
see also: HyperCLDB: cl5280
comment: There is a CLO term for the cell line already: http://purl.obolibrary.org/obo/CLO_0009464
alternative term: U87 MG
imported from: clo.owl

Vero cell
type: Class
subclass of: immortal cell line cell
see also: HyperCLDB: cl4644
alternative term: Vero
see also: MeSH: D014709
see also: ATCC: CCL-81
imported from: clo.owl

VERO 76 cell
type: Class
subclass of: immortal cell line cell
see also: ATCC: CRL-1587
see also: HyperCLDB: cl4655
alternative term: VERO 76
imported from: clo.owl

VERO C1008 cell
type: Class
subclass of: immortal cell line cell
see also: HyperCLDB: cl4657
see also: ATCC: CRL-1586
see also: HyperCLDB: cl4656
alternative term: VERO C1008
imported from: clo.owl

SNB75 cell
type: Class
subclass of: immortal cell line cell
definition source: WEB: http://web.expasy.org/cellosaurus/CVCL_1706
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/3121170
alternative term: SNB-75
textual definition: A human glioblastoma cell line cell. The cell line is part of the NCI-60 screening panel.
term editor: Oliver He, Jiangan Xie
LINCS ID: LCL-1346
see also: Sanger: COSMIC ID:905982
alternative term: SNB75
definition source: WEB: https://strap.nci.nih.gov/celline_detail.php?sample_id=56
see also: PubChem AID: 652144
imported from: clo.owl

SU-DHL-10 cell
type: Class
subclass of: immortal cell line cell
alternative term: SU-DHL-10
see also: DSMZ: ACC 576
term editor: Oliver He, Jiangan Xie
LINCS ID: LCL-1134
imported from: clo.owl

SU-DHL-6 cell
type: Class
subclass of: immortal cell line cell
LINCS ID: LCL-1138
see also: DSMZ: ACC 572
term editor: Oliver He, Jiangan Xie
alternative term: SU-DHL-6
imported from: clo.owl

BJeLR cell
type: Class
subclass of: immortal cell line cell
definition source: PubChem probe report: http://www.ncbi.nlm.nih.gov/books/NBK98919/
alternative term: BJeLR
term editor: YH, JX
definition source: PubMed: http://www.ncbi.nlm.nih.gov/pubmed/18355723
textual definition: BJeLR cell is BJ fibroblast cell line cell transformed with hTERT, genomic SV40 LT and ST oncoproteins, and oncogenic HRASV12.
see also: PubChem AID: 2635
imported from: clo.owl

BJeH cell
type: Class
subclass of: immortal cell line cell
definition source: PubMed: http://www.ncbi.nlm.nih.gov/pubmed/18355723
textual definition: BJeH=BJ derivative transformed only with hTERT (BJ fibroblasts were derived from primary human cells by transformation with hTERT, genomic SV40 Large T (LT) and Ssmall T (ST))
see also: PUbChem AID: 493051
definition source: PubChem probe report: http://www.ncbi.nlm.nih.gov/books/NBK98919/
term editor: YH, JX
alternative term: BJeLR
imported from: clo.owl

RS-11846 cell
type: Class
subclass of: immortal cell line cell
term editor: Oliver He, Jiangan Xie
definition source: WEB: http://cellfinder.org/ontology?id=CELDA_00012667
see also: PubChem AID: 743410
alternative term: RS11846
textual definition: A human follicular lymphoms cell line
see also: RRID: CVCL_E048
imported from: clo.owl

CHO-S cell
type: Class
subclass of: immortal cell line cell
term editor: YH, JX
see also: PubChem AID: 624379
textual definition: A derivative of the CHO cell line that is adapted to high-density, serum-free suspension culture
definition source: WEB: https://www.thermofisher.com/order/catalog/product/R80007
imported from: clo.owl

DRD cell
type: Class
subclass of: immortal cell line cell
textual definition: DRD=BJ fibroblasts expressing hTERT, SV40 small T oncoprotein, dominant negative p53, cyclin D1, a mutant form of CDK4, along with the oncogene HRASV12
definition source: WEB: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683762/
see also: PubChem AID: 2633
term editor: JX, YH
imported from: clo.owl

HL2/3
type: Class
subclass of: immortal cell line cell
definition source: WEB: https://www.aidsreagent.org/reagentdetail.cfm?t=cell_lines&id=83
definition source: WEB: https://www.ncbi.nlm.nih.gov/pubmed/?term=2078409
textual definition: HL2/3 is a derivative of HeLa cells and contains a stably integrated copies of the HIV-1 molecular clone HXB2/3gpt.
see also: PubChem AID: 504574
term editor: JX, YH
imported from: clo.owl

HeLa-MAGI-CCR5
type: Class
subclass of: immortal cell line cell
textual definition: HeLa-MAGI-CCR5 cells are derived from HeLa cells and express human CD4, CXCR4 and CCR5, and an integrated gene encoding the b-galactosidase gene expressed from the HIV long terminal repeat.
see also: RRID: CVCL_D260
definition source: WEB: http://web.expasy.org/cellosaurus/CVCL_D260
comment: MAGI-CCR5 cells; HeLa-R5-16, engineered to express the Envelope protein (Env) from the CCR5-tropic HIV-1 clinical isolate 92US715, and also to express the Tat protein from HIV-1 NL4 3
see also: PubChem AID: 504341
term editor: JX, YH
imported from: clo.owl

HeLa-R5-16
type: Class
subclass of: immortal cell line cell
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/?term=16314403
term editor: JX, YH
see also: PubChem AID: 504341
textual definition: HeLa-R5-16 (gift from Roche Palo Alto, LLC) is a derivative of HeLa cells, engineered to express the Envelope protein (Env) from the CCR5-tropic HIV-1 clinical isolate 92US715, and also to express the Tat protein from HIV-1 NL43
imported from: clo.owl

RD-HGA16
type: Class
subclass of: immortal cell line cell
see also: PubChem AID: 624467
textual definition: RD-HGA16 is derivative of CHO cells stably transfected with the promiscuous G-protein Gα16 gene and hygromycin-resistant. RD-HGA16 is from FLIPR LiveWare Cells (Molecular Devices, Sunnyvale CA), a series of cells and expression vectors successfully used in drug discovery, based on G-protein chimeras developed by Bruce Conklin and colleagues at the Gladstone Institute, UCSF.
term editor: YH, JX
definition source: WEB: http://go.pardot.com/l/83942/2015-06-17/njr/83942/4464/Data_Sheet__FLIPR_LiveWare_G_protein_Cells_and_Plasmids.pdf
imported from: clo.owl

Sufu-KO-LIGHT cell
type: Class
subclass of: immortal cell line cell
term editor: JX, YH
definition source: WEB: https://www.google.com/patents/WO2013192301A1?cl=en
textual definition: Sufu-KO-LIGHT cells were derived from Sufu knockout mouse embryonic fibroblasts according to the method of Chen et al. [Genes Dev. 2009;23(16): 1910-28.] The cells were co-transfected with the zeocin resistance vector (pVgRXR, Invitrogen) and a firefly luciferase reporter driven by eight Gli binding sites and a γ-crystallin basal promoter (8XGHBS-FL). Sufu-KO-LIGHT lacks Sufu and exhibits constitutive Hh target gene expression in response to endogenous Gli activators.
see also: PubChem AID: 588413
imported from: clo.owl

Ub-G76V-GFP/HeLa
type: Class
subclass of: immortal cell line cell
see also: PubChem AID: 463185
textual definition: A Hela-derived cell line cell that expresses ubiquitinated GFP (Green Fluroescent Protein)
term editor: JX, YH
imported from: clo.owl

GripTite 293 MSR cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 602478
alternative term: GripTite™ 293 MSR
definition source: https://www.thermofisher.com/order/catalog/product/R79507
definition source: https://pubchem.ncbi.nlm.nih.gov/bioassay/602478
term editor: BAO, YH
textual definition: The GripTite™ 293 MSR Cell Line is a genetically engineered Human Embryonic Kidney (HEK 293) cell line that expresses the human macrophage scavenger receptor and strongly adheres to standard tissue culture plates for dependable results.
see also: BAO: BAO_0030043
see also: ThermoFisher: R79507
imported from: clo.owl

2B4/BCL-2 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 493062
term editor: BAO, YH
definition source: http://www.ncbi.nlm.nih.gov/pubmed/16697956
definition source: https://www.google.com/patents/WO2007123791A2
textual definition: A mouse T-cell hybridoma cell line cell that is derived from the murine hybridoma cell line 2B4, stably transfected to overexpress the human protein BCL-2.
definition source: https://www.ncbi.nlm.nih.gov/books/NBK143557
see also: BAO: BAO_0030042
imported from: clo.owl

2B4/MCL-1 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 493059
see also: BAO: BAO_0030044
term editor: BAO, YH
definition source: http://www.ncbi.nlm.nih.gov/pubmed/16697956
definition source: https://www.google.com/patents/WO2007123791A2
definition source: https://www.ncbi.nlm.nih.gov/books/NBK143557
textual definition: A mouse T-cell hybridoma cell line cell that is derived from the murine hybridoma cell line 2B4, stably transfected to overexpress the human protein MCL-1.
imported from: clo.owl

AVA5 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 463235
textual definition: AVA5 cells are derived from the Huh-7 human hepatoma cell line, stably-expressing the HCV replicon (sub-genomic [CON1], genotype 1b); http://www.apath.com/index.html. See also PMID: 27013634, 1110665, 10390360
definition source: https://www.ncbi.nlm.nih.gov/pubmed/1110665
definition source: https://www.ncbi.nlm.nih.gov/pubmed/10390360
definition source: https://www.ncbi.nlm.nih.gov/pubmed/27013634
term editor: BAO, YH
see also: BAO: BAO_0030045
imported from: clo.owl

BCL-2 1863 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 624396
textual definition: A murine leukemia cell line driven by the overexpression of Myc and BCL-2.
see also: BAO: BAO_0030052
term editor: BAO, YH
definition source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919900/
imported from: clo.owl

C17.2 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 1353
term editor: BAO, YH
textual definition: An immortalised mouse neural progenitor cell line cell that is capable of differentiation in vitro and is established by retorviral-mediated transduction of the avian myc oncogene into mitotic progenitor cells of neonatal mouse cerrebellum. Mouse strain CD1 x C57BL/6.
definition source: http://www.sigmaaldrich.com/catalog/product/sigma/07062902
see also: BAO: BAO_0030046
definition source: http://web.expasy.org/cellosaurus/CVCL_4511
imported from: clo.owl

CEM21 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 651610
alternative term: CEM#21
term editor: Oliver He
alternative term: CEM-R5Luc1#21
see also: BAO: BAO_0030049
definition source: https://www.ncbi.nlm.nih.gov/pubmed/10516002
textual definition: CEM21 (aka CEM#21 or CEM-R5Luc1#21) is derived from CEM.NKR-CCR5 by stable transfecttion of a Tet-activator responsive Luciferase reporter
imported from: clo.owl

DPX2 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 434939
term editor: BAO, YH
definition source: http://www.ncbi.nlm.nih.gov/pubmed/22912432
see also: BAO: BAO_0030035
definition source: http://www.ncbi.nlm.nih.gov/pubmed/15548381
textual definition: DPX2 (aka DPX-2) is a HepG2-derived cell line stably integrated with a PXR (pregnane X receptor) expression vector plus a luciferase reporter, used to detect PXR activation/ CYP3A induction
alternative term: DPX-2
imported from: clo.owl

FA2N-4 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 623928
see also: BAO: BAO_0030036
definition source: http://web.expasy.org/cellosaurus/CVCL_0267
term editor: BAO, YH
definition source: http://purl.bioontology.org/ontology/MCCL/MCC_0000158
textual definition: FA2N-4 is a human hepatocyte cell line. Reference: http://web.expasy.org/cellosaurus/CVCL_0267
definition source: http://cellfinder.org/ontology
imported from: clo.owl

HBL-1 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 651646
textual definition: HBL-1 (aka human is an EBV-negative B-cell lymphoma cell line established from the pleural effusion of a patient with malignant lymphoma, diffuse, large cell.
term editor: BAO, YH
definition source: http://purl.obolibrary.org/obo/BTO_0002522
definition source: http://web.expasy.org/cellosaurus/CVCL_4213
see also: BTO: BTO_0002522
see also: BAO: BAO_0030037
imported from: clo.owl

HMC-1-8 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 449755
textual definition: HMC-1-8 is a human breast cancer cell line
definition source: http://portals.broadinstitute.org/ccle/cell%20lines/HMC18_BREAST
see also: BAO: BAO_0030037
term editor: BAO, YH
definition source: http://web.expasy.org/cellosaurus/CVCL_2949
imported from: clo.owl

HMLE_sh_ECAD cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 2717
see also: BAO: BAO_0030038
textual definition: HMLE_sh_ECAD is a stable cell line mimicking a cancer stem cell (CSC), derived by knocking down E-Cadherin (via shRNA) in human breast epithelial cells to induce epithelial to mesenchymal transition (EMT)
term editor: BAO, YH
definition source: http://www.ncbi.nlm.nih.gov/pubmed/22941295
definition source: http://www.ncbi.nlm.nih.gov/pubmed/19682730
imported from: clo.owl

HMLE_sh_eGFP cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 463074
definition source: http://www.ncbi.nlm.nih.gov/pubmed/19682730
term editor: BAO, YH
textual definition: HMLE_sh_eGFP is a human breast epithelial cell line containing shRNA to GFP (green fluorescent reporter); used as an isogenic control line for HMLE_sh_ECAD
definition source: http://www.ncbi.nlm.nih.gov/pubmed/22941295
see also: BAO: BAO_0030039
imported from: clo.owl

HMLE_sh_TWIST cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 588703
see also: BAO: BAO_0030040
textual definition: HMLE_sh_TWIST is a stable cell line mimicking a cancer stem cell (CSC), derived by knocking down TWIST (via shRNA) in human breast epithelial cells to induce epithelial to mesenchymal transition (EMT); isogenic with another CSC line, HMLE_sh_ECAD
definition source: http://www.ncbi.nlm.nih.gov/pubmed/19682730
term editor: BAO, YH
definition source: http://www.ncbi.nlm.nih.gov/pubmed/22941295
imported from: clo.owl

LEADING LIGHT Wnt Reporter cell line cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 651570
see also: BAO: BAO_0030031
definition source: http://www.enzolifesciences.com/ENZ-61001/leading-light-wnt-reporter-assay-starter-kit/
textual definition: An engineered 3T3 mouse fibroblast cell line, which expresses the firefly luciferase reporter gene under the control of Wnt-responsive promoters (TCF/LEF).
imported from: clo.owl

MCL-1 1780 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 624396
textual definition: MCL-1 1780 is a murine leukemia cell line driven by the overexpression of Myc and MCL-1.
term editor: BAO, YH
definition source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919900/
comment: Source: Anthony Letai (Dana Farber)
see also: BAO: BAO_0030053
imported from: clo.owl

MG213 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 652260
textual definition: MG213 is a subline of the BRG1/BRM-deficient cell line SW13 (http://purl.obolibrary.org/obo/CLO_0009185) that contains a stably integrated glucocorticoid-responsive MMTV-luciferase reporter.
term editor: BAO, YH
see also: BAO: BAO_0030048
definition source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615482/
imported from: clo.owl

PathHunter CHO-K1 DRD2L Beta-Arrestin cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 624495
term editor: BAO, YH
see also: BAO: BAO_0030056
textual definition: A PathHunter Beta-Arrestin GPCR cell line (DiscoverX), engineered to co-express the ProLink (PK) tagged GPCR (DRD2L, long form of human DRD2) and the Enzyme Acceptor (EA) tagged Beta-Arrestin. Activation of DRD2L-PK induces Beta-Arrestin-EA recruitment, forcing complementation of the two Beta-galactosidase enzyme fragments (EA and PK). The resulting functional enzyme hydrolyzes substrate to generate a chemiluminescent signal.
definition source: https://www.discoverx.com/products/cell-line/cho-k1-drd2l-beta-arrestin-cell-line-93-0579c2
imported from: clo.owl

PathHunter CHO-K1 DRD3 Beta-Arrestin cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 624500
definition source: https://www.discoverx.com/products/cell-line/cho-k1-drd3-beta-arrestin-cell-line-93-0591c2
term editor: BAO, YH
textual definition: A PathHunter Beta-Arrestin GPCR cell line (DiscoverX), engineered to co-express the ProLink (PK) tagged GPCR (human DRD3) and the Enzyme Acceptor (EA) tagged Beta-Arrestin. Activation of DRD3-PK induces Beta-Arrestin-EA recruitment, forcing complementation of the two Beta-galactosidase enzyme fragments (EA and PK). The resulting functional enzyme hydrolyzes substrate to generate a chemiluminescent signal.
see also: BAO: BAO_0030057
imported from: clo.owl

RAW-Blue cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 652166
see also: BAO: BAO_0030060
definition source: http://web.expasy.org/cellosaurus/CVCL_X594
textual definition: RAW-Blue cells are derived from the murine RAW 264.7 macrophages with chromosomal integration of a secreted embryonic alkaline phosphatase (SEAP) reporter construct inducible by NF-κB and AP-1.
term editor: BAO, YH
definition source: http://www.invivogen.com/raw-blue
imported from: clo.owl

S16 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 624032
alternative term: S-16 cell
textual definition: A rat immortilized Schwann cell line.
see also: BAO: BAO_0030061
see also: BTO: BTO_0002937
definition source: http://purl.obolibrary.org/obo/BTO_0002937
definition source: http://web.expasy.org/cellosaurus/CVCL_B072
imported from: clo.owl

SW1 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 1355
see also: BAO: BAO_0030062
textual definition: A mouse melanoma cell line (which harbors N-Ras mutation), isolated from a small amelanotic lung metastasis in a mouse with a s.c. K-1735 tumor.
definition source: http://www.ncbi.nlm.nih.gov/pubmed/2832058/
definition source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158838/
imported from: clo.owl

Tango cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 485366
definition source: https://www.ncbi.nlm.nih.gov/pubmed/18165312
definition source: http://www.ncbi.nlm.nih.gov/pubmed/25895059
textual definition: 'Tango cell' refers to one of many stable cell lines, all based on the parental line HEK293T, designed to work in a 'Tango beta-arrestin' recruitiment assay to measure receptor activation for more than 300 GPCRs. See PMID25895059 and https://pdspdb.unc.edu/prestotango/
definition source: https://pdspdb.unc.edu/prestotango/
term editor: BAO, YH
see also: BTO: BAO_0030063
imported from: clo.owl

TMD8 cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 651712
textual definition: Human diffuse large B cell lymphoma cell line derived from a 62-year-old male patient
term editor: BAO, YH
see also: BAO: BAO_0030064
definition source: http://web.expasy.org/cellosaurus/CVCL_A442
imported from: clo.owl

U87-EGFRvIII cell
type: Class
subclass of: immortal cell line cell
PubChem AID: 504935
textual definition: U87-EGFRvIII (aka U87/vIII) is a stable cell line derived from U87MG (a human glioblastoma) to overexpress the most common mutation of epidermal growth factor receptor (EGFR) found in human glioblastomas--an in-frame deletion of an 801-bp sequence in the extracellular domain of EGFR termed EGFRvIII. (descr. in PMID 15548697).
see also: BAO: BAO_0030059
term editor: BAO, YH
alternative term: U87/vIII
definition source: http://www.ncbi.nlm.nih.gov/pubmed/15548697/
imported from: clo.owl

MDCK-II cell
type: Class
subclass of: immortal cell line cell
definition source: https://pubmed.ncbi.nlm.nih.gov/21982418/
alternative term: MDCKII
definition source: https://www.cellosaurus.org/CVCL_0424
alternative term: MDCK II
see also: BTO; BTO:0004607
see also: Wikidata; Q54904781
alternative term: MDCK-I
alternative term: MDCK-2
see also: HyperCLDB: cl5079
see also: ChEMBL-Cells; CHEMBL3308862
alternative term: MDCKII-WT
alternative term: MDCK2
alternative term: MDCK Type II
imported from: clo.owl

MDCKII-LE cell
type: Class
subclass of: immortal cell line cell
definition source: https://pubmed.ncbi.nlm.nih.gov/21766308/
alternative term: Ralph Russ Canine Kidney
alternative term: MDCKII-LE
alternative term: RRCK
definition source: https://www.cellosaurus.org/CVCL_VR40
see also: Wikidata; Q95987829
textual definition: Compared to the parent cell line, has a lower expression of endogenous ABCB1/MDR1.
alternative term: MDCKII-Low Efflux
imported from: clo.owl