in_subset
type: AnnotationProperty

has_exact_synonym
type: AnnotationProperty

definition
type: AnnotationProperty

has_related_synonym
type: AnnotationProperty

imported from
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty

has_alternative_id
type: AnnotationProperty

has_obo_namespace
type: AnnotationProperty

has_narrow_synonym
type: AnnotationProperty

has_broad_synonym
type: AnnotationProperty

mitotic G1 phase
type: Class
subclass of: G1 phase
has_exact_synonym: G1 phase of mitotic cell cycle
id: GO:0000080
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
database_cross_reference: Reactome:REACT_101162
database_cross_reference: Reactome:REACT_1590
database_cross_reference: Reactome:REACT_29795
database_cross_reference: Reactome:REACT_34060
database_cross_reference: Reactome:REACT_78665
database_cross_reference: Reactome:REACT_78866
database_cross_reference: Reactome:REACT_83686
database_cross_reference: Reactome:REACT_91654
database_cross_reference: Reactome:REACT_93384
database_cross_reference: Reactome:REACT_93574
definition: The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis.
has_obo_namespace: biological_process
imported from: go.owl
in_subset: gocheck do not annotate

mitotic S phase
type: Class
subclass of: S phase
id: GO:0000084
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
database_cross_reference: Reactome:REACT_105829
database_cross_reference: Reactome:REACT_108550
database_cross_reference: Reactome:REACT_110039
database_cross_reference: Reactome:REACT_28988
database_cross_reference: Reactome:REACT_32013
database_cross_reference: Reactome:REACT_34043
database_cross_reference: Reactome:REACT_78838
database_cross_reference: Reactome:REACT_78845
database_cross_reference: Reactome:REACT_81914
database_cross_reference: Reactome:REACT_82813
database_cross_reference: Reactome:REACT_85811
database_cross_reference: Reactome:REACT_89318
database_cross_reference: Reactome:REACT_899
database_cross_reference: Reactome:REACT_92500
database_cross_reference: Reactome:REACT_92759
database_cross_reference: Reactome:REACT_95174
database_cross_reference: Reactome:REACT_96081
database_cross_reference: Reactome:REACT_97603
database_cross_reference: Reactome:REACT_99645
has_exact_synonym: S phase of mitotic cell cycle
has_exact_synonym: S-phase of mitotic cell cycle
definition: The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle.
has_obo_namespace: biological_process
imported from: go.owl
in_subset: gocheck do not annotate

mitotic G2 phase
type: Class
subclass of: G2 phase
has_exact_synonym: G2 phase of mitotic cell cycle
id: GO:0000085
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
database_cross_reference: Reactome:REACT_105223
database_cross_reference: Reactome:REACT_105307
database_cross_reference: Reactome:REACT_106415
database_cross_reference: Reactome:REACT_106836
database_cross_reference: Reactome:REACT_1915
database_cross_reference: Reactome:REACT_28975
database_cross_reference: Reactome:REACT_85928
database_cross_reference: Reactome:REACT_96332
definition: The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis.
has_obo_namespace: biological_process
imported from: go.owl

mitotic M phase
type: Class
subclass of: M phase
definition: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle.
id: GO:0000087
has_exact_synonym: M phase of mitotic cell cycle
has_exact_synonym: M-phase of mitotic cell cycle
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
database_cross_reference: Reactome:REACT_105412
database_cross_reference: Reactome:REACT_107095
database_cross_reference: Reactome:REACT_109059
database_cross_reference: Reactome:REACT_29488
database_cross_reference: Reactome:REACT_33490
database_cross_reference: Reactome:REACT_82055
database_cross_reference: Reactome:REACT_87132
database_cross_reference: Reactome:REACT_88263
database_cross_reference: Reactome:REACT_910
database_cross_reference: Reactome:REACT_92998
database_cross_reference: Reactome:REACT_93131
database_cross_reference: Reactome:REACT_93566
database_cross_reference: Reactome:REACT_93720
database_cross_reference: Reactome:REACT_94536
has_obo_namespace: biological_process
imported from: go.owl
in_subset: gocheck do not annotate

MAPK import into nucleus
type: Class
subclass of: protein import into nucleus
id: GO:0000189
comment: Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex.
database_cross_reference: Reactome:REACT_103042
database_cross_reference: Reactome:REACT_105886
database_cross_reference: Reactome:REACT_106064
database_cross_reference: Reactome:REACT_107045
database_cross_reference: Reactome:REACT_110766
database_cross_reference: Reactome:REACT_113196
database_cross_reference: Reactome:REACT_114932
database_cross_reference: Reactome:REACT_115101
database_cross_reference: Reactome:REACT_1866
database_cross_reference: Reactome:REACT_29004
database_cross_reference: Reactome:REACT_32259
database_cross_reference: Reactome:REACT_33595
database_cross_reference: Reactome:REACT_487
database_cross_reference: Reactome:REACT_510
database_cross_reference: Reactome:REACT_78269
database_cross_reference: Reactome:REACT_79422
database_cross_reference: Reactome:REACT_81446
database_cross_reference: Reactome:REACT_87335
database_cross_reference: Reactome:REACT_89933
database_cross_reference: Reactome:REACT_94910
database_cross_reference: Reactome:REACT_95119
database_cross_reference: Reactome:REACT_97762
definition: The directed movement of a MAP kinase to the nucleus upon activation.
has_obo_namespace: biological_process
has_narrow_synonym: nuclear translocation of MAPK
imported from: go.owl

mitotic cell cycle
type: Class
subclass of: cell cycle
id: GO:0000278
definition: Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
database_cross_reference: Reactome:REACT_100451
database_cross_reference: Reactome:REACT_104035
database_cross_reference: Reactome:REACT_104195
database_cross_reference: Reactome:REACT_105856
database_cross_reference: Reactome:REACT_108233
database_cross_reference: Reactome:REACT_152
database_cross_reference: Reactome:REACT_28464
database_cross_reference: Reactome:REACT_28953
database_cross_reference: Reactome:REACT_33388
database_cross_reference: Reactome:REACT_53493
database_cross_reference: Reactome:REACT_79085
database_cross_reference: Reactome:REACT_84794
database_cross_reference: Reactome:REACT_85137
database_cross_reference: Reactome:REACT_85950
database_cross_reference: Reactome:REACT_90332
database_cross_reference: Reactome:REACT_90846
database_cross_reference: Reactome:REACT_96281
database_cross_reference: Reactome:REACT_97744
database_cross_reference: Reactome:REACT_98208
has_obo_namespace: biological_process
imported from: go.owl
in_subset: goslim yeast

M phase
type: Class
subclass of: cell cycle phase
definition: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase.
id: GO:0000279
has_exact_synonym: M-phase
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
database_cross_reference: Wikipedia:M_phase
has_obo_namespace: biological_process
imported from: go.owl
in_subset: gocheck do not annotate

response to reactive oxygen species
type: Class
subclass of: biological_process
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
id: GO:0000302
has_obo_namespace: biological_process
has_exact_synonym: response to AOS
has_exact_synonym: response to ROI
has_exact_synonym: response to ROS
has_exact_synonym: response to active oxygen species
has_exact_synonym: response to reactive oxidative species
has_exact_synonym: response to reactive oxygen intermediate
imported from: go.owl
in_subset: gosubset prok

alternative mRNA splicing, via spliceosome
type: Class
subclass of: biological_process
id: GO:0000380
comment: Note that this process most commonly occurs in cis, selecting or skipping exons from the same primary transcript, but it has also been observed to occur in trans at low frequency, at least in some mammals.
definition: The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.
has_exact_synonym: alternative nuclear mRNA splicing, via spliceosome
has_obo_namespace: biological_process
has_broad_synonym: splice site selection
imported from: go.owl

nucleosome
type: Class
subclass of: cellular_component
definition: A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.
id: GO:0000786
has_alternative_id: GO:0005718
database_cross_reference: Wikipedia:Nucleosome
has_obo_namespace: cellular_component
imported from: go.owl
in_subset: goslim pir

dopamine neurotransmitter receptor activity, coupled via Gs
type: Class
subclass of: signaling
definition: Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity.
id: GO:0001588
has_alternative_id: GO:0001589
has_alternative_id: GO:0001590
has_narrow_synonym: dopamine D1 receptor activity
has_narrow_synonym: dopamine D5 receptor activity
has_obo_namespace: molecular_function
imported from: go.owl

dopamine neurotransmitter receptor activity, coupled via Gi/Go
type: Class
subclass of: receptor activity
definition: Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity.
id: GO:0001591
has_alternative_id: GO:0001592
has_alternative_id: GO:0001593
has_alternative_id: GO:0001670
has_narrow_synonym: dopamine D2 receptor activity
has_narrow_synonym: dopamine D3 receptor activity
has_narrow_synonym: dopamine D4 receptor activity
has_obo_namespace: molecular_function
imported from: go.owl

response to hypoxia
type: Class
subclass of: biological_process
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
id: GO:0001666
comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%.
has_obo_namespace: biological_process
has_exact_synonym: response to hypoxic stress
has_exact_synonym: response to lowered oxygen tension
imported from: go.owl

cytokine production
type: Class
subclass of: biological_process
id: GO:0001816
comment: Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules.
definition: The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
has_obo_namespace: biological_process
has_narrow_synonym: interferon production
has_narrow_synonym: interleukin production
imported from: go.owl
in_subset: goslim pir

steroid hormone receptor import into nucleus
type: Class
subclass of: biological_process
creation date: 2009-07-09T02:34:42Z
id: GO:0002146
comment: Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex.
definition: The directed movement of a steroid hormone receptor into the nucleus.
has_obo_namespace: biological_process
created by: hjd
has_narrow_synonym: steroid hormone receptor nuclear translocation
imported from: go.owl

glucocorticoid receptor import into nucleus
type: Class
subclass of: biological_process
creation date: 2009-07-09T02:36:09Z
id: GO:0002147
definition: The directed movement of a glucocorticoid receptor into the nucleus.
has_obo_namespace: biological_process
has_narrow_synonym: glucocorticoid receptor nuclear translocation
created by: hjd
imported from: go.owl

thrombocyte differentiation
type: Class
subclass of: biological_process
id: GO:0002574
comment: Note that platelets are the non-nucleated mammalian functional equivalent of the nucleated thrombocytes of non-mammalian vertebrates and are sometimes also referred to as thrombocytes. Platelet formation in mammals is covered by the biological_process term platelet formation ; GO:0030220.
definition: The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis.
has_obo_namespace: biological_process
imported from: go.owl

regulation of acute inflammatory response
type: Class
subclass of: biological_process
definition: Any process that modulates the frequency, rate, or extent of an acute inflammatory response.
id: GO:0002673
has_obo_namespace: biological_process
imported from: go.owl

molecular_function
type: Class
definition: Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
id: GO:0003674
has_alternative_id: GO:0005554
comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. Note that when this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
has_exact_synonym: molecular function
has_narrow_synonym: molecular function unknown
has_obo_namespace: molecular_function
imported from: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast
in_subset: gosubset prok

catalytic activity
type: Class
subclass of: molecular_function
definition: Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
id: GO:0003824
database_cross_reference: Wikipedia:Enzyme
has_exact_synonym: enzyme activity
has_obo_namespace: molecular_function
imported from: go.owl
in_subset: goslim pir
in_subset: goslim plant
in_subset: gosubset prok

GTPase activity
type: Class
subclass of: biological_process
has_narrow_synonym: ARF small monomeric GTPase activity
definition: Catalysis of the reaction: GTP + H2O = GDP + phosphate.
id: GO:0003924
database_cross_reference: RHEA:19672
has_narrow_synonym: RHEB small monomeric GTPase activity
has_narrow_synonym: Rab small monomeric GTPase activity
has_narrow_synonym: Ran small monomeric GTPase activity
has_narrow_synonym: Ras small monomeric GTPase activity
database_cross_reference: Reactome:REACT_100432
database_cross_reference: Reactome:REACT_100708
database_cross_reference: Reactome:REACT_101121
database_cross_reference: Reactome:REACT_101520
database_cross_reference: Reactome:REACT_101563
database_cross_reference: Reactome:REACT_101678
database_cross_reference: Reactome:REACT_102040
database_cross_reference: Reactome:REACT_102208
database_cross_reference: Reactome:REACT_102307
database_cross_reference: Reactome:REACT_102371
database_cross_reference: Reactome:REACT_102510
database_cross_reference: Reactome:REACT_102532
database_cross_reference: Reactome:REACT_103518
database_cross_reference: Reactome:REACT_104081
database_cross_reference: Reactome:REACT_104477
database_cross_reference: Reactome:REACT_104739
database_cross_reference: Reactome:REACT_105323
database_cross_reference: Reactome:REACT_105697
database_cross_reference: Reactome:REACT_105708
database_cross_reference: Reactome:REACT_105854
database_cross_reference: Reactome:REACT_106121
database_cross_reference: Reactome:REACT_106217
database_cross_reference: Reactome:REACT_106301
database_cross_reference: Reactome:REACT_106528
database_cross_reference: Reactome:REACT_107176
database_cross_reference: Reactome:REACT_107306
database_cross_reference: Reactome:REACT_107730
database_cross_reference: Reactome:REACT_107820
database_cross_reference: Reactome:REACT_108363
database_cross_reference: Reactome:REACT_108653
database_cross_reference: Reactome:REACT_108825
database_cross_reference: Reactome:REACT_108837
database_cross_reference: Reactome:REACT_109360
database_cross_reference: Reactome:REACT_109897
database_cross_reference: Reactome:REACT_110131
database_cross_reference: Reactome:REACT_110443
database_cross_reference: Reactome:REACT_110557
database_cross_reference: Reactome:REACT_110859
database_cross_reference: Reactome:REACT_110879
database_cross_reference: Reactome:REACT_110931
database_cross_reference: Reactome:REACT_111994
database_cross_reference: Reactome:REACT_112104
database_cross_reference: Reactome:REACT_112254
database_cross_reference: Reactome:REACT_112389
database_cross_reference: Reactome:REACT_112587
database_cross_reference: Reactome:REACT_112651
database_cross_reference: Reactome:REACT_112671
database_cross_reference: Reactome:REACT_113058
database_cross_reference: Reactome:REACT_113209
database_cross_reference: Reactome:REACT_113727
database_cross_reference: Reactome:REACT_113832
database_cross_reference: Reactome:REACT_113952
database_cross_reference: Reactome:REACT_113954
database_cross_reference: Reactome:REACT_114148
database_cross_reference: Reactome:REACT_114153
database_cross_reference: Reactome:REACT_114188
database_cross_reference: Reactome:REACT_114210
database_cross_reference: Reactome:REACT_114331
database_cross_reference: Reactome:REACT_114379
database_cross_reference: Reactome:REACT_114384
database_cross_reference: Reactome:REACT_114532
database_cross_reference: Reactome:REACT_114620
database_cross_reference: Reactome:REACT_114824
database_cross_reference: Reactome:REACT_115229
database_cross_reference: Reactome:REACT_115324
database_cross_reference: Reactome:REACT_12396
database_cross_reference: Reactome:REACT_12397
database_cross_reference: Reactome:REACT_12456
database_cross_reference: Reactome:REACT_12612

receptor activity
type: Class
subclass of: molecular_function
definition: Combining with an extracellular or intracellular messenger to initiate a change in cell activity.
id: GO:0004872
has_alternative_id: GO:0019041
has_obo_namespace: molecular_function
has_narrow_synonym: receptor guanylate cyclase activity
has_narrow_synonym: viral antireceptor activity
imported from: go.owl
in_subset: goslim metagenomics
in_subset: goslim plant
in_subset: gosubset prok

beta-adrenergic receptor activity
type: Class
subclass of: receptor activity
definition: Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein.
id: GO:0004939
has_exact_synonym: beta adrenoceptor
has_obo_namespace: molecular_function
imported from: go.owl

receptor binding
type: Class
subclass of: protein binding
id: GO:0005102
definition: Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
database_cross_reference: Wikipedia:Ligand_(biochemistry)
has_obo_namespace: molecular_function
has_narrow_synonym: receptor ligand
has_related_synonym: receptor-associated protein activity
imported from: go.owl
in_subset: goslim metagenomics
in_subset: goslim plant
in_subset: gosubset prok

binding
type: Class
subclass of: molecular_function
comment: For ligands that bind to signal transducing receptors, consider the molecular function term 'receptor binding ; GO:0005102' and its children.
id: GO:0005488
definition: The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
database_cross_reference: Wikipedia:Binding_(molecular)
has_narrow_synonym: ligand
has_obo_namespace: molecular_function
imported from: go.owl
in_subset: goslim pir
in_subset: goslim plant
in_subset: gosubset prok

protein binding
type: Class
subclass of: binding
id: GO:0005515
has_alternative_id: GO:0045308
definition: Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
database_cross_reference: Reactome:REACT_100287
database_cross_reference: Reactome:REACT_101129
database_cross_reference: Reactome:REACT_102084
database_cross_reference: Reactome:REACT_102457
database_cross_reference: Reactome:REACT_103972
database_cross_reference: Reactome:REACT_104029
database_cross_reference: Reactome:REACT_104599
database_cross_reference: Reactome:REACT_105776
database_cross_reference: Reactome:REACT_105895
database_cross_reference: Reactome:REACT_106168
database_cross_reference: Reactome:REACT_106189
database_cross_reference: Reactome:REACT_107402
database_cross_reference: Reactome:REACT_108283
database_cross_reference: Reactome:REACT_109392
database_cross_reference: Reactome:REACT_110419
database_cross_reference: Reactome:REACT_110570
database_cross_reference: Reactome:REACT_15321
database_cross_reference: Reactome:REACT_15325
database_cross_reference: Reactome:REACT_15355
database_cross_reference: Reactome:REACT_15417
database_cross_reference: Reactome:REACT_15419
database_cross_reference: Reactome:REACT_15506
database_cross_reference: Reactome:REACT_15541
database_cross_reference: Reactome:REACT_20509
database_cross_reference: Reactome:REACT_20539
database_cross_reference: Reactome:REACT_28794
database_cross_reference: Reactome:REACT_30571
database_cross_reference: Reactome:REACT_30672
database_cross_reference: Reactome:REACT_31305
database_cross_reference: Reactome:REACT_31537
database_cross_reference: Reactome:REACT_31641
database_cross_reference: Reactome:REACT_31648
database_cross_reference: Reactome:REACT_32973
database_cross_reference: Reactome:REACT_33135
database_cross_reference: Reactome:REACT_34719
database_cross_reference: Reactome:REACT_6923
database_cross_reference: Reactome:REACT_6945
database_cross_reference: Reactome:REACT_78382
database_cross_reference: Reactome:REACT_78466
database_cross_reference: Reactome:REACT_79634
database_cross_reference: Reactome:REACT_80470
database_cross_reference: Reactome:REACT_80778
database_cross_reference: Reactome:REACT_83147
database_cross_reference: Reactome:REACT_83165
database_cross_reference: Reactome:REACT_83532
database_cross_reference: Reactome:REACT_85250
database_cross_reference: Reactome:REACT_85858
database_cross_reference: Reactome:REACT_85975
database_cross_reference: Reactome:REACT_87187
database_cross_reference: Reactome:REACT_87374
database_cross_reference: Reactome:REACT_87652
database_cross_reference: Reactome:REACT_88068
database_cross_reference: Reactome:REACT_88138
database_cross_reference: Reactome:REACT_88223
database_cross_reference: Reactome:REACT_89261
database_cross_reference: Reactome:REACT_90027
database_cross_reference: Reactome:REACT_90105
database_cross_reference: Reactome:REACT_90666
database_cross_reference: Reactome:REACT_91560
database_cross_reference: Reactome:REACT_92029
database_cross_reference: Reactome:REACT_93175
database_cross_reference: Reactome:REACT_93938
database_cross_reference: Reactome:REACT_94522
database_cross_reference: Reactome:REACT_94808
database_cross_reference: Reactome:REACT_95241
database_cross_reference: Reactome:REACT_95561
database_cross_reference: Reactome:REACT_95647
database_cross_reference: Reactome:REACT_96236
database_cross_reference: Reactome:REACT_96264
database_cross_reference: Reactome:REACT_98028
database_cross_reference: Reactome:REACT_98807
has_related_synonym: alpha-2 macroglobulin receptor-associated protein activity
has_obo_namespace: molecular_function
has_exact_synonym: protein amino acid binding

cellular_component
type: Class
id: GO:0005575
has_alternative_id: GO:0008372
database_cross_reference: NIF_Subcellular:sao1337158144
comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. Note that when this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
definition: The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
has_exact_synonym: cellular component
has_narrow_synonym: cellular component unknown
has_obo_namespace: cellular_component
imported from: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast
in_subset: gosubset prok

nucleus
type: Class
subclass of: cellular_component
definition: A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
id: GO:0005634
database_cross_reference: NIF_Subcellular:sao1702920020
database_cross_reference: Wikipedia:Cell_nucleus
has_exact_synonym: cell nucleus
has_obo_namespace: cellular_component
imported from: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

nuclear envelope
type: Class
subclass of: cellular_component
id: GO:0005635
has_alternative_id: GO:0005636
definition: The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
database_cross_reference: Wikipedia:Nuclear_envelope
has_obo_namespace: cellular_component
imported from: go.owl
in_subset: goslim generic
in_subset: goslim plant

cytoplasm
type: Class
subclass of: cellular_component
definition: All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
id: GO:0005737
database_cross_reference: Wikipedia:Cytoplasm
has_obo_namespace: cellular_component
imported from: go.owl
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim plant
in_subset: goslim yeast
in_subset: gosubset prok

mitochondrion
type: Class
subclass of: cellular_component
definition: A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
id: GO:0005739
database_cross_reference: NIF_Subcellular:sao1860313010
database_cross_reference: Wikipedia:Mitochondrion
has_obo_namespace: cellular_component
has_exact_synonym: mitochondria
imported from: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

lysosome
type: Class
subclass of: cellular_component
definition: A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
id: GO:0005764
database_cross_reference: NIF_Subcellular:sao585356902
database_cross_reference: Wikipedia:Lysosome
has_obo_namespace: cellular_component
imported from: go.owl
in_subset: goslim generic
in_subset: goslim plant

autophagic vacuole
type: Class
subclass of: cellular_component
definition: A double-membrane-bounded compartment in which endogenous cellular material is sequestered; known as autophagosome in yeast.
id: GO:0005776
has_exact_synonym: autophagosome
has_obo_namespace: cellular_component
imported from: go.owl

endoplasmic reticulum
type: Class
subclass of: cellular_component
has_exact_synonym: ER
id: GO:0005783
database_cross_reference: NIF_Subcellular:sao1036339110
definition: The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
database_cross_reference: Wikipedia:Endoplasmic_reticulum
has_obo_namespace: cellular_component
imported from: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Golgi apparatus
type: Class
subclass of: cellular_component
definition: A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
id: GO:0005794
has_broad_synonym: Golgi
has_exact_synonym: Golgi complex
has_narrow_synonym: Golgi ribbon
database_cross_reference: NIF_Subcellular:sao451912436
comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.
database_cross_reference: Wikipedia:Golgi_apparatus
has_obo_namespace: cellular_component
imported from: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

cytosol
type: Class
subclass of: cellular_component
id: GO:0005829
database_cross_reference: NIF_Subcellular:sao101633890
definition: The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
database_cross_reference: Wikipedia:Cytosol
has_obo_namespace: cellular_component
imported from: go.owl
in_subset: goslim aspergillus
in_subset: goslim generic
in_subset: goslim plant
in_subset: gosubset prok

plasma membrane
type: Class
subclass of: cellular_component
id: GO:0005886
has_alternative_id: GO:0005904
database_cross_reference: NIF_Subcellular:sao1663586795
definition: The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
database_cross_reference: Wikipedia:Cell_membrane
has_narrow_synonym: bacterial inner membrane
has_exact_synonym: cell membrane
has_obo_namespace: cellular_component
has_exact_synonym: cytoplasmic membrane
has_narrow_synonym: inner endospore membrane
has_broad_synonym: juxtamembrane
has_narrow_synonym: plasma membrane lipid bilayer
has_exact_synonym: plasmalemma
imported from: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim plant
in_subset: goslim yeast
in_subset: gosubset prok

DNA repair
type: Class
subclass of: biological_process
id: GO:0006281
database_cross_reference: Reactome:REACT_102034
database_cross_reference: Reactome:REACT_106650
database_cross_reference: Reactome:REACT_107446
database_cross_reference: Reactome:REACT_107692
database_cross_reference: Reactome:REACT_107752
database_cross_reference: Reactome:REACT_108864
database_cross_reference: Reactome:REACT_108881
database_cross_reference: Reactome:REACT_108903
database_cross_reference: Reactome:REACT_109956
database_cross_reference: Reactome:REACT_115642
database_cross_reference: Reactome:REACT_115836
database_cross_reference: Reactome:REACT_127
database_cross_reference: Reactome:REACT_216
database_cross_reference: Reactome:REACT_29531
database_cross_reference: Reactome:REACT_29636
database_cross_reference: Reactome:REACT_78051
database_cross_reference: Reactome:REACT_82907
database_cross_reference: Reactome:REACT_83608
database_cross_reference: Reactome:REACT_83660
database_cross_reference: Reactome:REACT_84835
database_cross_reference: Reactome:REACT_85522
database_cross_reference: Reactome:REACT_86513
database_cross_reference: Reactome:REACT_86902
database_cross_reference: Reactome:REACT_88201
database_cross_reference: Reactome:REACT_88946
database_cross_reference: Reactome:REACT_89524
database_cross_reference: Reactome:REACT_90385
database_cross_reference: Reactome:REACT_90952
database_cross_reference: Reactome:REACT_91094
database_cross_reference: Reactome:REACT_91330
database_cross_reference: Reactome:REACT_91442
database_cross_reference: Reactome:REACT_91576
database_cross_reference: Reactome:REACT_92707
database_cross_reference: Reactome:REACT_93704
database_cross_reference: Reactome:REACT_94204
database_cross_reference: Reactome:REACT_94769
database_cross_reference: Reactome:REACT_95050
database_cross_reference: Reactome:REACT_95158
database_cross_reference: Reactome:REACT_96052
database_cross_reference: Reactome:REACT_96452
database_cross_reference: Reactome:REACT_99277
definition: The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
database_cross_reference: Wikipedia:DNA_repair
has_obo_namespace: biological_process
imported from: go.owl
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim yeast
in_subset: gosubset prok

transcription, DNA-templated
type: Class
subclass of: gene expression
has_exact_synonym: DNA-dependent transcription
has_alternative_id: GO:0006350
id: GO:0006351
has_alternative_id: GO:0061018
has_alternative_id: GO:0061022
definition: The cellular synthesis of RNA on a template of DNA.
database_cross_reference: Wikipedia:Transcription_(genetics)
has_obo_namespace: biological_process
has_broad_synonym: cellular transcription
has_exact_synonym: cellular transcription, DNA-dependent
has_broad_synonym: transcription
has_related_synonym: transcription regulator activity
has_exact_synonym: transcription, DNA-dependent
imported from: go.owl
in_subset: goslim aspergillus
in_subset: goslim metagenomics
in_subset: goslim pombe
in_subset: gosubset prok

regulation of transcription, DNA-templated
type: Class
subclass of: biological_process
definition: Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
id: GO:0006355
has_alternative_id: GO:0032583
has_alternative_id: GO:0045449
has_alternative_id: GO:0061019
has_obo_namespace: biological_process
has_exact_synonym: regulation of cellular transcription, DNA-dependent
has_related_synonym: regulation of gene-specific transcription
has_exact_synonym: regulation of transcription, DNA-dependent
has_broad_synonym: transcriptional control
imported from: go.owl
in_subset: goslim pombe
in_subset: gosubset prok

translation
type: Class
subclass of: gene expression
id: GO:0006412
has_alternative_id: GO:0006416
has_alternative_id: GO:0006453
has_alternative_id: GO:0043037
database_cross_reference: Reactome:REACT_100338
database_cross_reference: Reactome:REACT_100851
database_cross_reference: Reactome:REACT_101045
database_cross_reference: Reactome:REACT_101324
database_cross_reference: Reactome:REACT_1014
database_cross_reference: Reactome:REACT_103420
database_cross_reference: Reactome:REACT_105544
database_cross_reference: Reactome:REACT_29980
database_cross_reference: Reactome:REACT_33559
database_cross_reference: Reactome:REACT_77710
database_cross_reference: Reactome:REACT_79784
database_cross_reference: Reactome:REACT_81734
database_cross_reference: Reactome:REACT_81833
database_cross_reference: Reactome:REACT_82171
database_cross_reference: Reactome:REACT_83429
database_cross_reference: Reactome:REACT_83530
database_cross_reference: Reactome:REACT_86996
database_cross_reference: Reactome:REACT_95535
database_cross_reference: Reactome:REACT_96394
definition: The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome.
database_cross_reference: Wikipedia:Translation_(genetics)
has_obo_namespace: biological_process
has_exact_synonym: protein anabolism
has_exact_synonym: protein biosynthesis
has_exact_synonym: protein biosynthetic process
has_exact_synonym: protein formation
has_exact_synonym: protein synthesis
has_exact_synonym: protein translation
imported from: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: gosubset prok

regulation of translation
type: Class
subclass of: biological_process
definition: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
id: GO:0006417
has_alternative_id: GO:0006445
has_obo_namespace: biological_process
has_exact_synonym: regulation of protein anabolism
has_exact_synonym: regulation of protein biosynthesis
has_exact_synonym: regulation of protein formation
has_exact_synonym: regulation of protein synthesis
imported from: go.owl
in_subset: goslim yeast
in_subset: gosubset prok

protein phosphorylation
type: Class
subclass of: biological_process
id: GO:0006468
definition: The process of introducing a phosphate group on to a protein.
has_obo_namespace: biological_process
has_exact_synonym: protein amino acid phosphorylation
imported from: go.owl
in_subset: goslim yeast
in_subset: gosubset prok

protein dephosphorylation
type: Class
subclass of: biological_process
id: GO:0006470
definition: The process of removing one or more phosphoric residues from a protein.
has_obo_namespace: biological_process
has_exact_synonym: protein amino acid dephosphorylation
imported from: go.owl
in_subset: goslim yeast
in_subset: gosubset prok

protein import into nucleus
type: Class
subclass of: biological_process
id: GO:0006606
definition: The directed movement of a protein from the cytoplasm to the nucleus.
has_obo_namespace: biological_process
has_exact_synonym: establishment of protein localization to nucleus
has_exact_synonym: protein import into cell nucleus
has_exact_synonym: protein nucleus import
has_exact_synonym: protein transport from cytoplasm to nucleus
imported from: go.owl

chloride transport
type: Class
subclass of: biological_process
id: GO:0006821
definition: The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_obo_namespace: biological_process
imported from: go.owl
in_subset: gosubset prok

autophagy
type: Class
subclass of: biological_process
id: GO:0006914
has_alternative_id: GO:0016238
definition: The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
database_cross_reference: Wikipedia:Autophagy_(cellular)
has_obo_namespace: biological_process
has_exact_synonym: chaperone-mediated autophagy
imported from: go.owl
in_subset: goslim pir
in_subset: goslim pombe

apoptotic process
type: Class
subclass of: biological_process
definition: A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathways) which typically lead to rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The process ends when the cell has died. The process is divided into a signaling pathway phase, and an execution phase, which is triggered by the former.
id: GO:0006915
has_alternative_id: GO:0006917
has_alternative_id: GO:0008632
database_cross_reference: Reactome:REACT_100045
database_cross_reference: Reactome:REACT_100962
database_cross_reference: Reactome:REACT_101249
database_cross_reference: Reactome:REACT_104187
database_cross_reference: Reactome:REACT_105149
database_cross_reference: Reactome:REACT_106405
database_cross_reference: Reactome:REACT_106672
database_cross_reference: Reactome:REACT_107264
database_cross_reference: Reactome:REACT_108651
database_cross_reference: Reactome:REACT_109165
database_cross_reference: Reactome:REACT_110081
database_cross_reference: Reactome:REACT_111964
database_cross_reference: Reactome:REACT_13526
database_cross_reference: Reactome:REACT_13638
database_cross_reference: Reactome:REACT_13643
database_cross_reference: Reactome:REACT_28087
database_cross_reference: Reactome:REACT_28795
database_cross_reference: Reactome:REACT_28816
database_cross_reference: Reactome:REACT_30266
database_cross_reference: Reactome:REACT_30361
database_cross_reference: Reactome:REACT_30371
database_cross_reference: Reactome:REACT_30548
database_cross_reference: Reactome:REACT_30763
database_cross_reference: Reactome:REACT_31349
database_cross_reference: Reactome:REACT_34139
database_cross_reference: Reactome:REACT_578
database_cross_reference: Reactome:REACT_77132
database_cross_reference: Reactome:REACT_77313
database_cross_reference: Reactome:REACT_77415
database_cross_reference: Reactome:REACT_78287
database_cross_reference: Reactome:REACT_78802
database_cross_reference: Reactome:REACT_79809
database_cross_reference: Reactome:REACT_82724
database_cross_reference: Reactome:REACT_83328
database_cross_reference: Reactome:REACT_85877
database_cross_reference: Reactome:REACT_86749
database_cross_reference: Reactome:REACT_86873
database_cross_reference: Reactome:REACT_87570
database_cross_reference: Reactome:REACT_88740
database_cross_reference: Reactome:REACT_88784
database_cross_reference: Reactome:REACT_89196
database_cross_reference: Reactome:REACT_90267
database_cross_reference: Reactome:REACT_91011
database_cross_reference: Reactome:REACT_91243
database_cross_reference: Reactome:REACT_93937
database_cross_reference: Reactome:REACT_94099
database_cross_reference: Reactome:REACT_95069
database_cross_reference: Reactome:REACT_95675
database_cross_reference: Reactome:REACT_97627
database_cross_reference: Reactome:REACT_99784
database_cross_reference: Reactome:REACT_99799
database_cross_reference: Wikipedia:Apoptosis
has_narrow_synonym: activation of apoptosis
has_narrow_synonym: apoptosis
has_related_synonym: apoptosis activator activity
has_narrow_synonym: apoptosis signaling
has_exact_synonym: apoptotic cell death
has_narrow_synonym: apoptotic program
has_exact_synonym: apoptotic programmed cell death
has_obo_namespace: biological_process
has_broad_synonym: cell suicide
has_broad_synonym: cellular suicide
has_related_synonym: commitment to apoptosis
has_related_synonym: induction of apoptosis
has_related_synonym: induction of apoptosis by p53
has_exact_synonym: programmed cell death by apoptosis
has_related_synonym: signaling (initiator) caspase activity
has_narrow_synonym: type I programmed cell death
imported from: go.owl

response to stress
type: Class
subclass of: biological_process
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
id: GO:0006950
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
has_obo_namespace: biological_process
has_related_synonym: response to abiotic stress
has_related_synonym: response to biotic stress
imported from: go.owl
in_subset: gocheck do not manually annotate
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim plant
in_subset: gosubset prok

inflammatory response
type: Class
subclass of: biological_process
id: GO:0006954
definition: The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
comment: This term was improved by GO_REF:0000022. It was moved.
database_cross_reference: Wikipedia:Inflammation
has_obo_namespace: biological_process
imported from: go.owl

cell cycle
type: Class
subclass of: biological_process
id: GO:0007049
definition: The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
database_cross_reference: Wikipedia:Cell_cycle
has_obo_namespace: biological_process
has_exact_synonym: cell-division cycle
imported from: go.owl
in_subset: gocheck do not manually annotate
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
in_subset: gosubset prok

cell cycle arrest
type: Class
subclass of: biological_process
definition: A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
id: GO:0007050
database_cross_reference: Reactome:REACT_104854
database_cross_reference: Reactome:REACT_110745
database_cross_reference: Reactome:REACT_21387
database_cross_reference: Reactome:REACT_34173
database_cross_reference: Reactome:REACT_34536
database_cross_reference: Reactome:REACT_78416
database_cross_reference: Reactome:REACT_78593
database_cross_reference: Reactome:REACT_79397
database_cross_reference: Reactome:REACT_80257
database_cross_reference: Reactome:REACT_80760
database_cross_reference: Reactome:REACT_81821
database_cross_reference: Reactome:REACT_84630
database_cross_reference: Reactome:REACT_86872
database_cross_reference: Reactome:REACT_90070
database_cross_reference: Reactome:REACT_90301
database_cross_reference: Reactome:REACT_92874
database_cross_reference: Reactome:REACT_92909
has_exact_synonym: arrest of cell cycle progression
has_obo_namespace: biological_process
has_exact_synonym: cessation of cell cycle
has_exact_synonym: termination of cell cycle
imported from: go.owl

signal transduction
type: Class
subclass of: biological_process
id: GO:0007165
has_alternative_id: GO:0023033
comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.
database_cross_reference: Reactome:REACT_100624
database_cross_reference: Reactome:REACT_102354
database_cross_reference: Reactome:REACT_112130
database_cross_reference: Reactome:REACT_112549
database_cross_reference: Reactome:REACT_113151
database_cross_reference: Reactome:REACT_113601
database_cross_reference: Reactome:REACT_113964
database_cross_reference: Reactome:REACT_114657
database_cross_reference: Reactome:REACT_114690
database_cross_reference: Reactome:REACT_114820
database_cross_reference: Reactome:REACT_114910
database_cross_reference: Reactome:REACT_115037
database_cross_reference: Reactome:REACT_115147
database_cross_reference: Reactome:REACT_12478
database_cross_reference: Reactome:REACT_31232
database_cross_reference: Reactome:REACT_78535
database_cross_reference: Reactome:REACT_89740
database_cross_reference: Reactome:REACT_93680
database_cross_reference: Reactome:REACT_98872
definition: The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
database_cross_reference: Wikipedia:Signal_transduction
has_obo_namespace: biological_process
has_narrow_synonym: signaling cascade
has_related_synonym: signaling pathway
has_narrow_synonym: signalling cascade
has_related_synonym: signalling pathway
imported from: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim plant
in_subset: gosubset prok

G-protein coupled receptor signaling pathway
type: Class
subclass of: biological_process
definition: A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.
has_exact_synonym: G protein coupled receptor protein signaling pathway
has_exact_synonym: G protein coupled receptor protein signalling pathway
has_exact_synonym: G-protein coupled receptor protein signal transduction
has_exact_synonym: G-protein coupled receptor protein signaling pathway
has_exact_synonym: G-protein coupled receptor signalling pathway
has_exact_synonym: G-protein-coupled receptor protein signaling pathway
has_exact_synonym: G-protein-coupled receptor protein signalling pathway
id: GO:0007186
has_exact_synonym: GPCR signaling pathway
has_exact_synonym: GPCR signalling pathway
has_obo_namespace: biological_process
imported from: go.owl

JAK-STAT cascade
type: Class
subclass of: biological_process
definition: Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins.
id: GO:0007259
has_exact_synonym: JAK-STAT signal transduction
database_cross_reference: Wikipedia:JAK-STAT_signaling_pathway
has_obo_namespace: biological_process
imported from: go.owl

neurotransmitter secretion
type: Class
subclass of: biological_process
id: GO:0007269
database_cross_reference: Reactome:REACT_100716
database_cross_reference: Reactome:REACT_102134
database_cross_reference: Reactome:REACT_102586
database_cross_reference: Reactome:REACT_102743
database_cross_reference: Reactome:REACT_105010
database_cross_reference: Reactome:REACT_105885
database_cross_reference: Reactome:REACT_110862
database_cross_reference: Reactome:REACT_11184
database_cross_reference: Reactome:REACT_113329
database_cross_reference: Reactome:REACT_115061
database_cross_reference: Reactome:REACT_13723
database_cross_reference: Reactome:REACT_29477
database_cross_reference: Reactome:REACT_29495
database_cross_reference: Reactome:REACT_29928
database_cross_reference: Reactome:REACT_77375
database_cross_reference: Reactome:REACT_85993
database_cross_reference: Reactome:REACT_91316
database_cross_reference: Reactome:REACT_95406
database_cross_reference: Reactome:REACT_99398
definition: The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.
has_obo_namespace: biological_process
has_exact_synonym: neurotransmitter release
imported from: go.owl

circadian rhythm
type: Class
subclass of: biological_process
definition: Any biological process in an organism that recurs with a regularity of approximately 24 hours.
id: GO:0007623
has_alternative_id: GO:0050895
database_cross_reference: Wikipedia:Circadian_rhythm
has_obo_namespace: biological_process
has_exact_synonym: circadian process
has_related_synonym: circadian response
has_related_synonym: response to circadian rhythm
imported from: go.owl
in_subset: gosubset prok

drug binding
type: Class
subclass of: binding
id: GO:0008144
definition: Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
has_obo_namespace: molecular_function
imported from: go.owl
in_subset: goslim pir
in_subset: gosubset prok

biological_process
type: Class
definition: Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
has_alternative_id: GO:0000004
has_alternative_id: GO:0007582
id: GO:0008150
comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. Note that when this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
database_cross_reference: Wikipedia:Biological_process
has_exact_synonym: biological process
has_narrow_synonym: biological process unknown
has_obo_namespace: biological_process
has_exact_synonym: physiological process
imported from: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim pombe
in_subset: goslim yeast
in_subset: gosubset prok

cell death
type: Class
subclass of: biological_process
definition: Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as "apoptotic bodies"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo.
id: GO:0008219
has_related_synonym: accidental cell death
has_obo_namespace: biological_process
has_related_synonym: necrosis
imported from: go.owl
in_subset: goslim generic
in_subset: goslim plant
in_subset: gosubset prok

cell proliferation
type: Class
subclass of: biological_process
id: GO:0008283
definition: The multiplication or reproduction of cells, resulting in the expansion of a cell population.
comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells.
has_obo_namespace: biological_process
imported from: go.owl
in_subset: goslim generic
in_subset: goslim pir
in_subset: gosubset prok

fatty acid catabolic process
type: Class
subclass of: biological_process
id: GO:0009062
definition: The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
database_cross_reference: Wikipedia:Fatty_acid_degradation
has_obo_namespace: biological_process
has_exact_synonym: fatty acid breakdown
has_exact_synonym: fatty acid catabolism
has_exact_synonym: fatty acid degradation
imported from: go.owl
in_subset: gosubset prok

quorum sensing
type: Class
subclass of: biological_process
id: GO:0009372
definition: The process in which single-celled organisms monitor their population density by detecting the concentration of small, diffusible signal molecules produced by the cells themselves.
database_cross_reference: Wikipedia:Quorum_sensing
has_obo_namespace: biological_process
has_exact_synonym: quorum sensing system
imported from: go.owl
in_subset: goslim pir
in_subset: gosubset prok

cell surface
type: Class
subclass of: cellular_component
has_alternative_id: GO:0009928
has_alternative_id: GO:0009929
id: GO:0009986
comment: Note that this term is intended to annotate gene products that are attached (integrated or loosely bound) to the plasma membrane or cell wall.
definition: The external part of the cell wall and/or plasma membrane.
has_exact_synonym: cell associated
has_exact_synonym: cell bound
has_obo_namespace: cellular_component
imported from: go.owl
in_subset: goslim pir
in_subset: gosubset prok

gene expression
type: Class
subclass of: biological_process
id: GO:0010467
database_cross_reference: Reactome:REACT_100537
database_cross_reference: Reactome:REACT_101147
database_cross_reference: Reactome:REACT_101952
database_cross_reference: Reactome:REACT_105649
database_cross_reference: Reactome:REACT_108313
database_cross_reference: Reactome:REACT_29068
database_cross_reference: Reactome:REACT_34240
database_cross_reference: Reactome:REACT_71
database_cross_reference: Reactome:REACT_78136
database_cross_reference: Reactome:REACT_78959
database_cross_reference: Reactome:REACT_79662
database_cross_reference: Reactome:REACT_85241
database_cross_reference: Reactome:REACT_85359
database_cross_reference: Reactome:REACT_86357
database_cross_reference: Reactome:REACT_89816
database_cross_reference: Reactome:REACT_91657
database_cross_reference: Reactome:REACT_91965
database_cross_reference: Reactome:REACT_93586
database_cross_reference: Reactome:REACT_93968
database_cross_reference: Reactome:REACT_94814
database_cross_reference: Reactome:REACT_98256
definition: The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
database_cross_reference: Wikipedia:Gene_expression
has_obo_namespace: biological_process
imported from: go.owl
in_subset: gosubset prok

regulation of gene expression
type: Class
subclass of: biological_process
definition: Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
id: GO:0010468
database_cross_reference: Wikipedia:Regulation_of_gene_expression
has_obo_namespace: biological_process
has_related_synonym: regulation of gene product expression
has_narrow_synonym: regulation of protein expression
imported from: go.owl
in_subset: gosubset prok

protein kinase A signaling
type: Class
subclass of: biological_process
definition: A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound.
id: GO:0010737
has_related_synonym: PKA signaling cascade
has_obo_namespace: biological_process
has_exact_synonym: protein kinase A signal transduction
has_related_synonym: protein kinase A signaling cascade
has_related_synonym: protein kinase A signalling cascade
imported from: go.owl

positive regulation of lipid storage
type: Class
subclass of: biological_process
definition: Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
id: GO:0010884
has_obo_namespace: biological_process
has_narrow_synonym: positive regulation of lipid sequestration
imported from: go.owl

negative regulation of lipid storage
type: Class
subclass of: biological_process
definition: Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
id: GO:0010888
has_obo_namespace: biological_process
imported from: go.owl

drug transport
type: Class
subclass of: biological_process
id: GO:0015893
definition: The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_obo_namespace: biological_process
imported from: go.owl
in_subset: goslim pir
in_subset: gosubset prok

viral process
type: Class
subclass of: biological_process
definition: A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.
id: GO:0016032
has_alternative_id: GO:0022415
database_cross_reference: Reactome:REACT_6145
database_cross_reference: Reactome:REACT_6185
database_cross_reference: Reactome:REACT_6256
comment: See also the biological process terms 'viral infectious cycle ; GO:0019058' and 'lysogeny ; GO:0030069'.
database_cross_reference: Wikipedia:Viral_life_cycle
has_obo_namespace: biological_process
has_related_synonym: viral infection
has_related_synonym: virulence
has_exact_synonym: virus process
imported from: go.owl
in_subset: goslim metagenomics
in_subset: goslim pir

RNA interference
type: Class
subclass of: biological_process
id: GO:0016246
comment: Note that this term refers specifically to posttranscriptional mechanisms by which small interfering RNAs down-regulate gene expression. Also consider annotating to other descendants of 'gene silencing by RNA ; GO:0031047'.
has_exact_synonym: RNAi
definition: The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes.
database_cross_reference: Wikipedia:RNA_interference
has_obo_namespace: biological_process
has_exact_synonym: posttranscriptional gene silencing by siRNA
imported from: go.owl

kinase activity
type: Class
subclass of: molecular_function
definition: Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
id: GO:0016301
comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term.
database_cross_reference: Reactome:REACT_100073
database_cross_reference: Reactome:REACT_100078
database_cross_reference: Reactome:REACT_100159
database_cross_reference: Reactome:REACT_100260
database_cross_reference: Reactome:REACT_100298
database_cross_reference: Reactome:REACT_100305
database_cross_reference: Reactome:REACT_100311
database_cross_reference: Reactome:REACT_100390
database_cross_reference: Reactome:REACT_100465
database_cross_reference: Reactome:REACT_100495
database_cross_reference: Reactome:REACT_100519
database_cross_reference: Reactome:REACT_100636
database_cross_reference: Reactome:REACT_100637
database_cross_reference: Reactome:REACT_101024
database_cross_reference: Reactome:REACT_101170
database_cross_reference: Reactome:REACT_101303
database_cross_reference: Reactome:REACT_101431
database_cross_reference: Reactome:REACT_101543
database_cross_reference: Reactome:REACT_101596
database_cross_reference: Reactome:REACT_101638
database_cross_reference: Reactome:REACT_101667
database_cross_reference: Reactome:REACT_101841
database_cross_reference: Reactome:REACT_101862
database_cross_reference: Reactome:REACT_101914
database_cross_reference: Reactome:REACT_102090
database_cross_reference: Reactome:REACT_102093
database_cross_reference: Reactome:REACT_102154
database_cross_reference: Reactome:REACT_102322
database_cross_reference: Reactome:REACT_102330
database_cross_reference: Reactome:REACT_102380
database_cross_reference: Reactome:REACT_102475
database_cross_reference: Reactome:REACT_102499
database_cross_reference: Reactome:REACT_102552
database_cross_reference: Reactome:REACT_102607
database_cross_reference: Reactome:REACT_102711
database_cross_reference: Reactome:REACT_102729
database_cross_reference: Reactome:REACT_102817
database_cross_reference: Reactome:REACT_102887
database_cross_reference: Reactome:REACT_102908
database_cross_reference: Reactome:REACT_102915
database_cross_reference: Reactome:REACT_103060
database_cross_reference: Reactome:REACT_103291
database_cross_reference: Reactome:REACT_103327
database_cross_reference: Reactome:REACT_103359
database_cross_reference: Reactome:REACT_103468
database_cross_reference: Reactome:REACT_103691
database_cross_reference: Reactome:REACT_103727
database_cross_reference: Reactome:REACT_103804
database_cross_reference: Reactome:REACT_103989
database_cross_reference: Reactome:REACT_104022
database_cross_reference: Reactome:REACT_104044
database_cross_reference: Reactome:REACT_104109
database_cross_reference: Reactome:REACT_104209
database_cross_reference: Reactome:REACT_104323
database_cross_reference: Reactome:REACT_104386
database_cross_reference: Reactome:REACT_104523
database_cross_reference: Reactome:REACT_104644
database_cross_reference: Reactome:REACT_104687
database_cross_reference: Reactome:REACT_104730
database_cross_reference: Reactome:REACT_104822
database_cross_reference: Reactome:REACT_104837
database_cross_reference: Reactome:REACT_104878
database_cross_reference: Reactome:REACT_105254
database_cross_reference: Reactome:REACT_105274
database_cross_reference: Reactome:REACT_105345
database_cross_reference: Reactome:REACT_105373
database_cross_reference: Reactome:REACT_105503
database_cross_reference: Reactome:REACT_105561
database_cross_reference: Reactome:REACT_105569
database_cross_reference: Reactome:REACT_105589
database_cross_reference: Reactome:REACT_105664
database_cross_reference: Reactome:REACT_105700
database_cross_reference: Reactome:REACT_105971
database_cross_reference: Reactome:REACT_105976

phosphorylation
type: Class
subclass of: biological_process
id: GO:0016310
definition: The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
database_cross_reference: Wikipedia:Phosphorylation
has_obo_namespace: biological_process
imported from: go.owl
in_subset: goslim metagenomics
in_subset: gosubset prok

viral genome replication
type: Class
subclass of: biological_process
definition: Any process involved directly in viral genome replication, including viral nucleotide metabolism.
id: GO:0019079
has_obo_namespace: biological_process
has_narrow_synonym: sigma virus replication
has_broad_synonym: viral replication
imported from: go.owl

second-messenger-mediated signaling
type: Class
subclass of: biological_process
definition: Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell.
id: GO:0019932
has_obo_namespace: biological_process
has_exact_synonym: second messenger mediated signaling
has_exact_synonym: second messenger mediated signalling
has_exact_synonym: second messenger-mediated signaling
has_exact_synonym: second messenger-mediated signalling
has_exact_synonym: second-messenger-mediated signal transduction
has_exact_synonym: second-messenger-mediated signalling
imported from: go.owl
in_subset: gosubset prok

cell cycle phase
type: Class
subclass of: biological_process
id: GO:0022403
definition: One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
has_obo_namespace: biological_process
imported from: go.owl
in_subset: gocheck do not annotate

signal transduction by phosphorylation
type: Class
subclass of: biological_process
creation date: 2010-02-16T09:30:50Z
definition: A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate.
comment: For annotation of intracellular kinases, consider also annotating to 'signal transduction by phosphorylation ; GO:0023014'.
id: GO:0023014
has_obo_namespace: biological_process
has_related_synonym: signal transduction via phosphorylation event
has_related_synonym: signal transmission via phosphorylation event
imported from: go.owl

signaling
type: Class
subclass of: biological_process
creation date: 2010-02-16T09:30:50Z
has_alternative_id: GO:0023046
id: GO:0023052
comment: Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change.
definition: The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
has_exact_synonym: biological signaling
has_obo_namespace: biological_process
has_exact_synonym: signaling process
has_exact_synonym: signalling
has_related_synonym: signalling process
imported from: go.owl
in_subset: goslim pombe
in_subset: goslim yeast

lamellipodium
type: Class
subclass of: cellular_component
definition: A thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments.
id: GO:0030027
database_cross_reference: Wikipedia:Lamellipodia
has_obo_namespace: cellular_component
imported from: go.owl

platelet activation
type: Class
subclass of: biological_process
definition: A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
id: GO:0030168
database_cross_reference: Reactome:REACT_103583
database_cross_reference: Reactome:REACT_105599
database_cross_reference: Reactome:REACT_108920
database_cross_reference: Reactome:REACT_109042
database_cross_reference: Reactome:REACT_118465
database_cross_reference: Reactome:REACT_28166
database_cross_reference: Reactome:REACT_29092
database_cross_reference: Reactome:REACT_29357
database_cross_reference: Reactome:REACT_32211
database_cross_reference: Reactome:REACT_798
database_cross_reference: Reactome:REACT_82375
database_cross_reference: Reactome:REACT_82964
database_cross_reference: Reactome:REACT_83720
database_cross_reference: Reactome:REACT_85922
database_cross_reference: Reactome:REACT_86767
database_cross_reference: Reactome:REACT_86968
database_cross_reference: Reactome:REACT_88667
database_cross_reference: Reactome:REACT_88938
database_cross_reference: Reactome:REACT_92635
database_cross_reference: Reactome:REACT_96250
database_cross_reference: Reactome:REACT_97013
has_obo_namespace: biological_process
has_exact_synonym: blood coagulation, platelet activation
imported from: go.owl

regulation of cell migration
type: Class
subclass of: biological_process
definition: Any process that modulates the frequency, rate or extent of cell migration.
id: GO:0030334
has_obo_namespace: biological_process
imported from: go.owl

axon
type: Class
subclass of: cellular_component
id: GO:0030424
database_cross_reference: NIF_Subcellular:sao1770195789
definition: The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
database_cross_reference: Wikipedia:Axon
has_obo_namespace: cellular_component
imported from: go.owl

regeneration
type: Class
subclass of: biological_process
id: GO:0031099
definition: The regrowth of a lost or destroyed body part, such as an organ or tissue.
database_cross_reference: Wikipedia:Regeneration_(biology)
has_obo_namespace: biological_process
imported from: go.owl

neuron projection regeneration
type: Class
subclass of: biological_process
id: GO:0031102
definition: The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage.
has_obo_namespace: biological_process
has_narrow_synonym: neurite regeneration
imported from: go.owl

neuron projection development
type: Class
subclass of: neuron development
id: GO:0031175
definition: The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
has_obo_namespace: biological_process
has_narrow_synonym: neurite biosynthesis
has_narrow_synonym: neurite development
has_narrow_synonym: neurite formation
has_narrow_synonym: neurite growth
has_narrow_synonym: neurite outgrowth
imported from: go.owl

adrenergic receptor binding
type: Class
subclass of: receptor binding
id: GO:0031690
definition: Interacting selectively and non-covalently with an adrenergic receptor.
has_narrow_synonym: adrenergic receptor ligand
has_obo_namespace: molecular_function
imported from: go.owl

D1 dopamine receptor binding
type: Class
subclass of: receptor binding
has_narrow_synonym: D1 dopamine receptor ligand
has_exact_synonym: D1A dopamine receptor binding
id: GO:0031748
definition: Interacting selectively and non-covalently with a D1 dopamine receptor.
has_obo_namespace: molecular_function
imported from: go.owl

D5 dopamine receptor binding
type: Class
subclass of: receptor binding
has_exact_synonym: D1B dopamine receptor binding
has_narrow_synonym: D5 dopamine receptor ligand
id: GO:0031752
definition: Interacting selectively and non-covalently with a D5 dopamine receptor.
has_obo_namespace: molecular_function
imported from: go.owl

bleb
type: Class
subclass of: cellular_component
definition: A cell extension characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusions.
id: GO:0032059
database_cross_reference: Wikipedia:Bleb_(cell_biology)
has_obo_namespace: cellular_component
imported from: go.owl
in_subset: goslim pir

production of miRNAs involved in gene silencing by miRNA
type: Class
subclass of: biological_process
definition: Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein.
has_alternative_id: GO:0030918
id: GO:0035196
has_obo_namespace: biological_process
has_exact_synonym: gene silencing by miRNA, production of miRNAs
has_related_synonym: miRNA biogenesis
has_exact_synonym: miRNA processing
has_exact_synonym: miRNA-mediated gene silencing, production of miRNAs
has_related_synonym: microRNA biogenesis
has_related_synonym: microRNA biosynthesis
has_related_synonym: microRNA biosynthetic process
has_related_synonym: microRNA metabolic process
has_related_synonym: microRNA metabolism
has_broad_synonym: microRNA processing
has_exact_synonym: microRNA-mediated gene silencing, production of microRNAs
has_exact_synonym: production of microRNAs involved in gene silencing by microRNA
imported from: go.owl

phenotypic switching
type: Class
subclass of: biological_process
creation date: 2012-03-27T01:31:28Z
definition: A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue, and from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
id: GO:0036166
comment: Mating type switching is not considered a type of phenotypic switching: for mating type switching, consider instead annotating to 'mating type switching ; GO:0007533'.
has_obo_namespace: biological_process
has_related_synonym: phenotypic dimorphism
created by: rfoulger
imported from: go.owl

regulation of gene expression, epigenetic
type: Class
subclass of: biological_process
definition: Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence.
id: GO:0040029
has_obo_namespace: biological_process
imported from: go.owl
in_subset: goslim plant
in_subset: gosubset prok

NF-kappaB import into nucleus
type: Class
subclass of: biological_process
id: GO:0042348
has_exact_synonym: NF-KB import into nucleus
has_exact_synonym: NF-kappaB import into cell nucleus
has_exact_synonym: NF-kappaB protein-nucleus import
has_exact_synonym: NF-kappaB transport from cytoplasm to nucleus
has_exact_synonym: NF-kappaB-nucleus import
definition: The directed movement of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.
has_obo_namespace: biological_process
imported from: go.owl

regulation of membrane potential
type: Class
subclass of: biological_process
definition: Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
id: GO:0042391
has_obo_namespace: biological_process
imported from: go.owl
in_subset: gosubset prok

response to drug
type: Class
subclass of: biological_process
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
has_alternative_id: GO:0017035
id: GO:0042493
has_obo_namespace: biological_process
has_related_synonym: drug resistance
has_related_synonym: drug susceptibility/resistance
imported from: go.owl
in_subset: goslim candida
in_subset: gosubset prok

biofilm formation
type: Class
subclass of: biological_process
definition: A process in which microorganisms irreversibly attach to and grow on a surface and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription.
id: GO:0042710
has_obo_namespace: biological_process
imported from: go.owl
in_subset: goslim candida
in_subset: goslim pir
in_subset: gosubset prok

transcription factor import into nucleus
type: Class
subclass of: protein import into nucleus
id: GO:0042991
definition: The directed movement of a transcription factor from the cytoplasm to the nucleus.
has_obo_namespace: biological_process
has_exact_synonym: transcription factor import into cell nucleus
has_exact_synonym: transcription factor transport from cytoplasm to nucleus
has_exact_synonym: transcription factor-nucleus import
imported from: go.owl

neuron projection
type: Class
subclass of: cellular_component
definition: A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
id: GO:0043005
database_cross_reference: NIF_Subcellular:sao-867568886
has_obo_namespace: cellular_component
has_narrow_synonym: neurite
has_exact_synonym: neuron process
has_exact_synonym: neuron protrusion
has_exact_synonym: neuronal cell projection
imported from: go.owl
in_subset: goslim pir

negative regulation of catalytic activity
type: Class
subclass of: biological_process
definition: Any process that stops or reduces the activity of an enzyme.
id: GO:0043086
has_obo_namespace: biological_process
has_exact_synonym: down regulation of enzyme activity
has_exact_synonym: down-regulation of enzyme activity
has_exact_synonym: downregulation of enzyme activity
has_narrow_synonym: inhibition of enzyme activity
has_exact_synonym: negative regulation of enzyme activity
imported from: go.owl
in_subset: gosubset prok

regulation of RNA splicing
type: Class
subclass of: biological_process
definition: Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
id: GO:0043484
has_obo_namespace: biological_process
imported from: go.owl

protein kinase B signaling
type: Class
subclass of: biological_process
definition: A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound.
has_exact_synonym: AKT signal transduction
has_exact_synonym: AKT signaling
has_related_synonym: AKT signaling cascade
has_exact_synonym: AKT signalling cascade
id: GO:0043491
has_exact_synonym: PKB signal transduction
has_exact_synonym: PKB signaling
has_related_synonym: PKB signaling cascade
has_related_synonym: PKB signalling cascade
has_obo_namespace: biological_process
has_exact_synonym: protein kinase B signal transduction
has_related_synonym: protein kinase B signaling cascade
has_related_synonym: protein kinase B signalling cascade
imported from: go.owl

cell body
type: Class
subclass of: cellular_component
creation date: 2010-02-05T10:37:16Z
id: GO:0044297
comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections.
definition: The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
has_exact_synonym: cell soma
has_obo_namespace: cellular_component
created by: jane
imported from: go.owl
in_subset: goslim pir

axon collateral
type: Class
subclass of: cellular_component
creation date: 2010-02-05T11:29:04Z
definition: Any of the smaller branches of an axon that emanate from the main axon cylinder.
id: GO:0044303
database_cross_reference: NIF_Subcellular:sao1470140754
has_obo_namespace: cellular_component
created by: jane
imported from: go.owl

dendritic branch
type: Class
subclass of: cellular_component
creation date: 2010-02-05T04:18:53Z
definition: A dendrite arising from another dendrite.
id: GO:0044307
database_cross_reference: NIF_Subcellular:sao884265541
has_obo_namespace: cellular_component
has_exact_synonym: dendrite branch
created by: jane
imported from: go.owl

negative regulation of membrane potential
type: Class
subclass of: regulation of membrane potential
definition: Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
id: GO:0045837
has_obo_namespace: biological_process
has_exact_synonym: down regulation of membrane potential
has_exact_synonym: down-regulation of membrane potential
has_exact_synonym: downregulation of membrane potential
has_narrow_synonym: inhibition of membrane potential
has_exact_synonym: reduction of membrane potential
imported from: go.owl

positive regulation of membrane potential
type: Class
subclass of: regulation of membrane potential
definition: Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
id: GO:0045838
has_narrow_synonym: activation of membrane potential
has_obo_namespace: biological_process
has_exact_synonym: elevation of membrane potential
has_narrow_synonym: stimulation of membrane potential
has_exact_synonym: up regulation of membrane potential
has_exact_synonym: up-regulation of membrane potential
has_exact_synonym: upregulation of membrane potential
imported from: go.owl

viral entry into host cell
type: Class
subclass of: biological_process
has_alternative_id: GO:0019063
id: GO:0046718
database_cross_reference: Reactome:REACT_6232
database_cross_reference: Reactome:REACT_6282
definition: The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
database_cross_reference: VZ:936
comment: Viral attachment to the host cell is not part of viral entry in GO because virus attachment does not always lead to viral entry: attachment can also result in the virion being carried by the host cell to another location.
has_obo_namespace: biological_process
has_exact_synonym: entry of virus into host cell
has_exact_synonym: phage translocation
has_exact_synonym: viral penetration
has_exact_synonym: virion penetration
has_exact_synonym: virion penetration into host cell
has_exact_synonym: virus entry into host cell
imported from: go.owl
in_subset: virus checked

neuron development
type: Class
subclass of: biological_process
id: GO:0048666
definition: The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
has_obo_namespace: biological_process
imported from: go.owl

neuron projection morphogenesis
type: Class
subclass of: biological_process
id: GO:0048812
definition: The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
has_obo_namespace: biological_process
has_narrow_synonym: neurite biosynthesis
has_narrow_synonym: neurite formation
has_narrow_synonym: neurite growth
has_related_synonym: neurite morphogenesis
imported from: go.owl

cytokine secretion
type: Class
subclass of: molecular_function
id: GO:0050663
definition: The regulated release of cytokines from a cell. Cytokines are any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
has_obo_namespace: biological_process
has_narrow_synonym: interferon secretion
has_narrow_synonym: interleukin secretion
imported from: go.owl

regulation of catalytic activity
type: Class
subclass of: biological_process
definition: Any process that modulates the activity of an enzyme.
id: GO:0050790
has_obo_namespace: biological_process
has_exact_synonym: regulation of enzyme activity
imported from: go.owl
in_subset: gosubset prok

protein stabilization
type: Class
subclass of: biological_process
definition: Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
id: GO:0050821
has_obo_namespace: biological_process
has_narrow_synonym: lysosomal protein stabilization
has_exact_synonym: positive regulation of protein stability
has_related_synonym: protein sequestering
has_related_synonym: protein stabilization activity
imported from: go.owl
in_subset: gosubset prok

regulation of sequence-specific DNA binding transcription factor activity
type: Class
subclass of: biological_process
definition: Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
id: GO:0051090
database_cross_reference: Reactome:REACT_104536
database_cross_reference: Reactome:REACT_107559
database_cross_reference: Reactome:REACT_109535
database_cross_reference: Reactome:REACT_110257
database_cross_reference: Reactome:REACT_110693
database_cross_reference: Reactome:REACT_21326
database_cross_reference: Reactome:REACT_82719
database_cross_reference: Reactome:REACT_83365
database_cross_reference: Reactome:REACT_90659
database_cross_reference: Reactome:REACT_92725
database_cross_reference: Reactome:REACT_96476
database_cross_reference: Reactome:REACT_99415
has_obo_namespace: biological_process
has_broad_synonym: regulation of transcription factor activity
imported from: go.owl
in_subset: gosubset prok

G1 phase
type: Class
subclass of: cell cycle phase
id: GO:0051318
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
definition: The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis.
database_cross_reference: Wikipedia:G1_phase
has_obo_namespace: biological_process
imported from: go.owl
in_subset: gocheck do not annotate

G2 phase
type: Class
subclass of: cell cycle phase
id: GO:0051319
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
definition: The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis).
database_cross_reference: Wikipedia:G2_phase
has_obo_namespace: biological_process
imported from: go.owl
in_subset: gocheck do not annotate

S phase
type: Class
subclass of: cell cycle phase
id: GO:0051320
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
has_exact_synonym: S-phase
definition: The cell cycle phase, following G1, during which DNA synthesis takes place.
database_cross_reference: Wikipedia:S_phase
has_obo_namespace: biological_process
imported from: go.owl
in_subset: gocheck do not annotate

meiotic cell cycle
type: Class
subclass of: cell cycle
id: GO:0051321
definition: Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell.
has_obo_namespace: biological_process
imported from: go.owl
in_subset: goslim yeast

meiotic M phase
type: Class
subclass of: M phase
definition: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a meiotic cell cycle.
id: GO:0051327
has_exact_synonym: M phase of meiotic cell cycle
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
has_obo_namespace: biological_process
imported from: go.owl
in_subset: gocheck do not annotate

meiotic G1 phase
type: Class
subclass of: G1 phase
has_exact_synonym: G1 phase of meiotic cell cycle
id: GO:0051330
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
definition: The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by meiosis and the beginning of DNA synthesis.
has_obo_namespace: biological_process
imported from: go.owl
in_subset: gocheck do not annotate

meiotic G2 phase
type: Class
subclass of: G2 phase
has_exact_synonym: G2 phase of meiotic cell cycle
id: GO:0051331
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
definition: The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by meiosis.
has_obo_namespace: biological_process
imported from: go.owl

meiotic S phase
type: Class
subclass of: S phase
id: GO:0051332
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
has_exact_synonym: S phase of meiotic cell cycle
has_exact_synonym: S-phase of meiotic cell cycle
definition: The cell cycle phase, following G1, during which DNA synthesis takes place as part of a meiotic cell cycle.
has_obo_namespace: biological_process
imported from: go.owl
in_subset: gocheck do not annotate

regulation of ubiquitin-protein ligase activity
type: Class
subclass of: biological_process
has_narrow_synonym: APC regulator
definition: Any process that modulates the frequency, rate or extent of ubiquitin ligase activity, the catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
id: GO:0051438
has_narrow_synonym: SCF complex regulator
has_narrow_synonym: anaphase-promoting complex regulator
has_obo_namespace: biological_process
has_exact_synonym: regulation of ubiquitin ligase activity
has_related_synonym: ubiquitin ligase regulator
has_related_synonym: ubiquitin-protein ligase regulator
imported from: go.owl

protein C-terminal methylesterase activity
type: Class
subclass of: biological_process
definition: Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol.
id: GO:0051722
has_obo_namespace: molecular_function
has_narrow_synonym: protein phosphatase methylesterase activity
imported from: go.owl

regulation of mitochondrial membrane potential
type: Class
subclass of: regulation of membrane potential
definition: Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
id: GO:0051881
has_obo_namespace: biological_process
imported from: go.owl

regulation of gene silencing by miRNA
type: Class
subclass of: biological_process
creation date: 2009-10-05T03:10:28Z
definition: Any process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression.
id: GO:0060964
has_obo_namespace: biological_process
created by: dph
has_exact_synonym: regulation of gene silencing by microRNA
imported from: go.owl

regulation of proteasomal protein catabolic process
type: Class
subclass of: biological_process
creation date: 2010-05-17T01:33:20Z
definition: Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
id: GO:0061136
has_obo_namespace: biological_process
created by: dph
imported from: go.owl

regulation of molecular function
type: Class
subclass of: biological_process
definition: Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
id: GO:0065009
has_obo_namespace: biological_process
has_exact_synonym: regulation of a molecular function
imported from: go.owl
in_subset: gosubset prok

necrotic cell death
type: Class
subclass of: biological_process
definition: A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues.
id: GO:0070265
comment: Note that the word necrosis has been widely used in earlier literature to describe forms of cell death which are now known by more precise terms, such as apoptosis. Necrosis can occur in a regulated fashion, involving a precise sequence of signals.
has_obo_namespace: biological_process
has_exact_synonym: cellular necrosis
has_broad_synonym: necrosis
imported from: go.owl

protein kinase C signaling
type: Class
subclass of: biological_process
definition: A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
id: GO:0070528
has_exact_synonym: PKC signal transduction
has_related_synonym: PKC signaling cascade
has_obo_namespace: biological_process
has_exact_synonym: protein kinase C signal transduction
has_related_synonym: protein kinase C signaling cascade
has_related_synonym: protein kinase C signalling cascade
imported from: go.owl

ER-associated misfolded protein catabolic process
type: Class
subclass of: biological_process
creation date: 2010-03-10T12:53:27Z
has_exact_synonym: ER-associated misfolded protein breakdown
has_exact_synonym: ER-associated misfolded protein catabolism
has_exact_synonym: ER-associated misfolded protein degradation
id: GO:0071712
comment: See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'.
definition: The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.
has_obo_namespace: biological_process
has_exact_synonym: endoplasmic reticulum-associated misfolded protein catabolic process
has_exact_synonym: endoplasmic reticulum-associated misfolded protein catabolism
created by: midori
imported from: go.owl

establishment of cell polarity regulating cell shape
type: Class
subclass of: biological_process
creation date: 2011-06-22T03:10:08Z
definition: Any cellular process that results in the specification or formation of a polarized intracellular organization or cell growth pattern that regulates the shape of a cell.
id: GO:0071964
has_obo_namespace: biological_process
created by: midori
imported from: go.owl

axon microtubule bundle
type: Class
subclass of: cellular_component
creation date: 2012-11-07T15:37:12Z
definition: An arrangement of closely apposed microtubules running parallel to each other in the axon hillock and initial segment.
id: GO:1901589
database_cross_reference: NIF_Subcellular:sao707332678
has_exact_synonym: axon microtubule fascicle
has_obo_namespace: cellular_component
has_exact_synonym: microtubule bundle of axon
has_exact_synonym: microtubule fascicle of axon
created by: pr
imported from: go.owl