BioAssay Ontology
type: Ontology
date: October 5, 2025
version info: 2.8.18
label: BAO
license: https://creativecommons.org/licenses/by-sa/4.0/
comment: Created by: Caty Chung, Nicolette Ross, Joan Glenny-Pescov, Jiaming Hu, Stephan Schurer*
comment: Contact: Stephan Schurer stephan dot schurer at med dot miami dot edu

nucleic acid
type: Class
subclass of: biological macromolecule

induced pluripotent stem cell
type: Class
IAO_0000118: iPSC

Luciferin 4-monooxygenase
type: Class
IAO_0000118: luciferase
IAO_0000118: Firefly luciferase
IAO_0000115: An oxidative enzyme that catalyzes the conversion of luciferin to oxyluciferin with the concomitant emission of light (luminescence).
subclass of: oxidoreductase

lipid
type: Class
IAO_0000115: Lipids are a group of naturally occurring organic compounds that are soluble in nonpolar organic solvents, but insoluble in water. Examples include fatty acids, triglycerides, phospholipids, etc. Lipids function to store energy, form a component of cell membrane and as signaling molecules.
subclass of: biological macromolecule

protein
type: Class
IAO_0000115: A protein or polypeptide is a long polymer of amino acids joined together by peptide bonds. The sequence of the amino acids is defined by the genetic code. Here, a protein is a perturbagen whereby its ability to modulate a physiological process or a disease pathology is assessed.
subclass of: biological macromolecule

Interleukin-6
type: Class
IAO_0000118: IL-6
subclass of: secreted

generic hydrolase
type: Class
IAO_0000115: Includes all hydrolases except phosphatases and proteases.
subclass of: hydrolase

PNA
type: Class
IAO_0000118: protein nucleic acid
IAO_0000115: PNA or protein nucleic acid is an artificially synthesized polymer whose backbone is composed of repeating N-(2-aminoethyl)-glycine units linked by peptide bonds. Since PNA does not contain charged phosphate groups in its backbone, the interaction between PNA-DNA is stronger than that between DNA-DNA due to the lack of electrostatic repulsion.
subclass of: RNA

virus
type: Class
IAO_0000115: Viruses are small infectious agents that depend on the host cells to reproduce. Outside the host, they contain a protein coat called capsid that encloses their genetic material (either DNA or RNA). Viruses can infect bacteria, plants and animals and cause a number of diseases, e.g. smallpox, chickenpox, influenza, polio, rabies, etc.
subclass of: organism

unicellular fungi
type: Class
IAO_0000115: It includes the baker's yeast (Saccharomyces cerevisiae) and fission yeast (Schizosaccharomyces pombe), which are unicellular.
subclass of: fungi

Tumor necrosis factor
type: Class
subclass of: secreted

adhesion
type: Class
IAO_0000115: The proteins located on the cell surface which are involved with the binding with other cells or the extracellular matrix. They belong to 5 families: Immunoglobulin superfamily, integrins, cadherins, selectins and the lymphocyte homing receptors.
subclass of: protein

primary cell
type: Class
IAO_0000115: Cells that are cultured from a subject (tissue or tumor) and which are not immortalized. They can undergo only a limited number of cell divisions prior to reaching senescence.

biological process
type: Class
IAO_0000115: Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end (from GO).
deprecated: true
subclass of: assay biology component

DNA
type: Class
IAO_0000115: DNA or deoxyribonucleic acid is the genetic material in all the living things, and some viruses. It is a polymer of nucleotides, with a backbone made of deoxyribose sugar and phosphate groups joined together by ester bonds.
subclass of: nucleic acid

RNA
type: Class
IAO_0000115: RNA or ribonucleic acid is a polymer of nucleotides with a backbone made of ribose sugar and phosphate groups linked together by ester bonds. RNA has the base uracil instead of thymine, which is present in DNA.
subclass of: nucleic acid

Interferon gamma
type: Class
IAO_0000118: IFN-gamma
subclass of: secreted

mRNA
type: Class
IAO_0000115: mRNA or messenger RNA is a genetic intermediate between DNA and protein. It is transcribed from DNA by RNA polymerases which is further processed by other enzymes. mRNA serves as the template to synthesize proteins on the ribosomes.
subclass of: RNA

rRNA
type: Class
IAO_0000115: rRNA or ribosomal RNAs are present in ribosomes in a cell. Ribosomes are protein translation machinery which can read messenger RNAs and translate that information into proteins.
subclass of: RNA

tRNA
type: Class
IAO_0000115: tRNA or transfer RNA is a small RNA molecule that transfers a specific active amino acid to a growing polypeptide chain at the ribosomal site of protein synthesis.
subclass of: RNA

chaperone
type: Class
IAO_0000115: They have an essential role in the regulation of protein conformation states. Molecular chaperones help nascent polypeptides fold correctly and multimeric protein complexes assemble properly, and reduce the possibility of protein aggregation.
subclass of: cytosolic protein

enzyme regulator
type: Class
IAO_0000115: It modulates the activity of an enzyme.
subclass of: protein

enzyme
type: Class
IAO_0000115: Enzymes are biological catalysts involved in important pathways that allow chemical reactions to occur at higher rates (velocities) than would be possible without the enzyme. Enzymes are generally globular proteins that have one or more substrate binding sites.
subclass of: protein

ion channel
type: Class
IAO_0000115: Ion channels are present in the cell membrane. They are pore-forming protein complexes that facilitate diffusion of ions across membranes and thus establish the small voltage gradient across the plasma membrane of living cells.
subclass of: transmembrane receptor

receptor
type: Class
IAO_0000115: A membrane or intracellular protein that specifically binds a known stimulus of cellular activity, such as a hormone, growth factor, antigen, neurotransmitter, drug, etc.
subclass of: protein

transcription factor
type: Class
IAO_0000115: It is a protein that binds to a specific sequence of DNA (upstream of the genes that it regulates) and regulates gene expression.
subclass of: protein

transporter
type: Class
IAO_0000115: A transporter protein is a transmembrane protein that helps transport small molecules and proteins across the membrane. This is done using facilitated diffusion or active transport.
subclass of: protein

G protein coupled receptor
type: Class
IAO_0000115: G protein-coupled receptors (GPCRs), comprise the largest integral membrane protein family with nearly 1000 members. They integrate extracellular signals from hormones, growth factors, neurotransmitters, etc to downstream cellular responses. They are important pharmacological targets, being associated with a number of diseases. Upon ligand binding extracellularly, the GPCR signals through a downstream heterotrimeric G protein complex, consisting of the α, β and γ subunits.
subclass of: transmembrane receptor

transmembrane receptor
type: Class
IAO_0000115: Transmembrane receptors are integral membrane proteins in either the cell- or organelle-membrane. They bind specific hormones, neurotransmitters, cytokines, growth factors, etc and initiate cell signaling, which results in changes in the cell function.
subclass of: receptor

nuclear receptor
type: Class
IAO_0000115: Nuclear receptors are localized in the cytosol and mediate the activity of hormones and certain vitamins. They are all transcription factors, which upon activation by ligand binding, translocate to the nucleus, bind specific DNA sequence and activate gene expression.
subclass of: receptor

hydrolase
type: Class
IAO_0000115: Formation of two products from a substrate by hydrolysis.
subclass of: enzyme

isomerase
type: Class
IAO_0000115: Intramolecule rearrangement, i.e. isomerization changes within a single molecule.
subclass of: enzyme

ligase
type: Class
IAO_0000115: Join together two molecules by synthesis of new C-O, C-S, C-N or C-C bonds with simultaneous breakdown of ATP.
subclass of: enzyme

lyase
type: Class
IAO_0000115: Non-hydrolytic addition or removal of groups from substrates. C-C, C-N, C-O or C-S bonds may be cleaved.
subclass of: enzyme

oxidoreductase
type: Class
IAO_0000115: To catalyze oxidation/reduction reactions; transfer of H and O atoms or electrons from one substance to another.
subclass of: enzyme

transferase
type: Class
IAO_0000115: Transfer of a functional group from one substance to another. The group may be methyl-, acyl-, amino- or phosphate group.
subclass of: enzyme

generic transferase
type: Class
IAO_0000115: Includes all transferases except kinases.
subclass of: transferase

kinase
type: Class
IAO_0000115: A protein kinase is an enzyme that modifies other proteins by chemically adding phosphate groups to them. The substrate protein's activity, localization and overall function is modulated by the kinase reaction.
subclass of: transferase

phosphatase
type: Class
IAO_0000115: A phosphatase is an enzyme that removes a phosphate group from its substrate by hydrolysis of phosphoric acid esters.
subclass of: hydrolase

cDNA
type: Class
IAO_0000118: complimentary deoxyribonucleic acid
IAO_0000115: cDNA or complementary DNA is complementary in sequence to a particular messenger RNA (mRNA). It is synthesized from mRNA in a reverse transcription reaction by reverse transcriptase enzyme. cDNA can be cloned in a vector and introduced into cells to bring about the expression of that particular gene in those cells.
subclass of: DNA

genomic DNA
type: Class
IAO_0000118: linear deoxyribonucleic acid
IAO_0000115: DNA that is linear and not circular. Examples of linear DNA include synthetic oligonucleotide, restriction endonuclease digestion product, polymerase chain reaction product, mechanically sheared genomic DNA, etc.
subclass of: DNA

plasmid DNA
type: Class
IAO_0000118: plasmid deoxyribonucleic acid
IAO_0000115: Plasmid is a double stranded circular DNA molecule that can replicate independently of the chromosomal DNA. It exists naturally in bacteria and some yeast. In genetic engineering, plasmids are exploited to clone and multiply a gene of interest. Several plasmid vectors are available commercially to introduce cloned DNA into different cell types.
subclass of: DNA

peptide
type: Class
IAO_0000115: Peptide is a short polymer of amino acids, which is generally <50 amino acids long.
subclass of: biological macromolecule

mammalian
type: Class
IAO_0000115: This includes animal models typically used in drug discovery for toxicity or pharmacology studies, such as mouse, rat (mammals).
subclass of: vertebrate

bacterium
type: Class
IAO_0000115: Bacteria lack membrane bound organelles and are surrounded by a rigid cell wall. Though they are unicellular, they function by aggregating into multicellular colonies.
subclass of: cellular organisms

cytosolic protein
type: Class
IAO_0000115: Proteins localized in the cytosol, but do not belong to the transcription factor, transporter, structural, enzyme, enzyme regulator and nuclear receptor classes of proteins in the cytosol.
subclass of: protein

membrane protein
type: Class
IAO_0000115: Membrane proteins are associated with the cell membrane. They can be classified into two broad categories
subclass of: protein

G protein
type: Class
IAO_0000115: There are two distinct G protein families, namely the heterotrimeric G proteins (consisting of the α, β and γ subunits) downstream of the G protein coupled receptors (GPCRs) and the monomeric G proteins that belong to the Ras superfamily of GTPases. Upon ligand binding, the GPCR undergoes a conformational change, which allows it to act as a guanine nucleotide exchange factor (GEF) of an associated G protein. The GTP-bound G α subunit then signals by regulating the activity of adenylate cyclase, phospholipase, or Rho GEFs.
subclass of: membrane protein

secreted
type: Class
IAO_0000115: These proteins are translocated from the inside of the cell to the cell's exterior. Proteins targeted for secretion undergo glycosylation and other postranslational modifications in the endoplasmic reticulum and the golgi complex, and are enclosed in secretory vesicles. The fusion of vesicles to the cell membrane releases the secretory proteins to the exterior. Examples include growth factors, tumor necrosis factors, cytokines, etc.
subclass of: protein

structural
type: Class
IAO_0000115: These proteins constitute the largest class with respect to the total protein mass. They are fibrous proteins, e.g. keratin, actin, myosin, etc whose primary function is to provide scaffolding that maintains cell shape.
subclass of: protein

generic membrane protein
type: Class
IAO_0000115: This class includes membrane proteins other than g-proteins, such as regulators of g-protein, GTPases, etc.
subclass of: membrane protein

LNA
type: Class
IAO_0000118: locked nucleic acid
IAO_0000115: Locked nucleic acid (LNA) is a nucleic acid analogue containing one or more LNA nucleotide monomers with a bicyclic furanose unit locked in an RNA mimicking sugar conformation. LNA oligonucleotides have high affinity toward complementary single-stranded RNA and complementary single- or double-stranded DNA. This makes LNA suitable for sequence specific targeting of RNA in vitro or in vivo.
subclass of: RNA

fungi
type: Class
IAO_0000115: Fungi are either unicellular or multicellular and include yeasts, molds, mushrooms, etc. Several parasitic fungi exist, which infect animals and plants, e.g., Aspergillus flavus, Claviceps purpurea, Pneumocystis jirovecii, etc.
subclass of: eukaryote

RNA aptamer
type: Class
IAO_0000118: ribonucleic acid aptamer
IAO_0000115: Aptamers are synthetic affinity probes. RNA aptamers are oligonucleotides that bind to a specific target molecule such as small molecules, proteins, nucleic acids and cells. They are created by selecting them from a large random sequence pool, but natural aptamers also exist in riboswitches.
subclass of: RNA

riboswitch
type: Class
IAO_0000115: They are part of mRNA that regulate gene expression through ligand induced changes in mRNA secondary or tertiary structure. The ligand is generally a small metabolite which binds to the aptamer part of the riboswitch.
subclass of: RNA

antibody
type: Class
IAO_0000115: Antibody is a protein (immunoglobulin) produced by the immune system of an organism in response to exposure to a foreign molecule (antigen) and characterized by its specific binding to a site of that molecule (antigenic determinant or epitope). Antibodies are used extensively as tools to characterize proteins. Antibodies are either monoclonal or polyclonal.
subclass of: protein complex

monoclonal
type: Class
IAO_0000115: Highly specific antibodies produced by the clones of a single hybrid cell, which is generated by the fusion of a B cell with a tumor cell. They recognize a unique epitope of an antigen.
subclass of: antibody

polyclonal
type: Class
IAO_0000115: Antibodies produced by immunizing a mammal such as a mouse, rabbit or goat with an antigen. They are a mixture of antibodies produced from different B cells raised against any of the different epitopes of that antigen.
subclass of: antibody

eukaryote
type: Class
IAO_0000115: This includes fungi, vertebrates and invertebrates. Eukaryotic cells have a well-defined nucleus and membrane enveloped organelles namely, mitochondria, endoplasmic reticulum, golgi apparatus, and lysosomes.
subclass of: cellular organisms

vertebrate
type: Class
IAO_0000115: This includes animals having a vertebral column, and model organisms from this group include the zebrafish, mouse, rat, etc
subclass of: metazoa

invertebrate
type: Class
IAO_0000115: These animals lack a vertebral column and many of which are used as model organisms in HTS screening including Drosophila, C.elegans, sea urchin, etc.
subclass of: metazoa

non-mammalian
type: Class
IAO_0000115: This includes vertebrate model organisms such as the Danio rerio (zebrafish), Xenopus laevis, etc which are tested generally to understand development.
subclass of: vertebrate

DNA construct
type: Class
IAO_0000118: deoxyribonucleic acid construct
IAO_0000115: A brief description of the recombinant DNA created by the insertion of a gene or siRNA encoding DNA of interest into a vector. It includes information on the type of vector, the type of promoter, the selectable markers, etc., which are all considered when sub-cloning a gene of interest. The construct is transfected into cells by various methods.
subclass of: biological macromolecule

organism
type: Class
IAO_0000115: The organism related to the target / meta-target of the bioassay. It includes both bacterium and eukaryote.
subclass of: assay biology component

multicellular fungi
type: Class
IAO_0000115: Most of the fungi are multicellular, e.g. molds, mushrooms, etc. They are made up of multicellular filaments known as hyphae. Several parasitic fungi exist, which infect animals and plants, e.g., Aspergillus flavus, Claviceps purpurea, Pneumocystis jirovecii, etc.
subclass of: fungi

gene
type: Class
IAO_0000115: A genomic sequence, which is the unit of heredity of a living organism. It consists of regulatory regions and transcribed regions.
subclass of: biological macromolecule

plant
type: Class
IAO_0000115: They are living organisms which derive their energy from photosynthesis, with the exception of parasitic plants. Plants include herbs, shrubs, trees, grasses, vines, etc.
subclass of: eukaryote

sea urchin
type: Class
subclass of: invertebrate

group a streptococcus
type: Class
IAO_0000115: Causes mild infections such as "strep throat" to severe diseases such as necrotizing fasciitis and streptococcal toxic shock syndrome.
subclass of: bacterium

influenza virus
type: Class
subclass of: virus

protease
type: Class
IAO_0000115: A protease is an enzyme that hydrolyzes the peptide bonds in a protein or a peptide.
subclass of: hydrolase

cellular organisms
type: Class
IAO_0000115: This includes all organisms which are made up of cells, e.g. bacteria, plants and animals.
subclass of: organism

metazoa
type: Class
IAO_0000115: Metazoa comprises of animals, which are multicellular eukaryotic organisms. This includes those having a vertebral column (e.g. fish, frog, snake, bird, human) and those that do not (e.g. worm, fly, star fish, etc).
subclass of: eukaryote

protozoan
type: Class
IAO_0000115: Protozoans are single celled organisms, some of which are parasitic, e.g., Plasmodium falciparum, Leishmania mexicana, Trypanosoma brucei, etc which cause malaria, leishmaniasis, and sleeping sickness, respectively.
subclass of: eukaryote

Epstein-Barr virus
type: Class
subclass of: virus

CD40
type: Class
subclass of: transmembrane receptor

CD4-TLR4
type: Class
comment: Fusion protein of CD4 and TLR4.
subclass of: transmembrane receptor

Cos-7
type: Class

Schneider's Drosophila Line 2
type: Class

FITC-RGS12-GoLoco peptide
type: Class
subclass of: peptide

Beta-galactosidase
type: Class
subclass of: generic hydrolase

Beta-lactamase
type: Class
subclass of: generic hydrolase

U937 (CD59+)
type: Class

Interleukin-3
type: Class
IAO_0000118: IL-3
subclass of: secreted

MurNAc-L-Ala-gamma-D-Glu-mDAP
type: Class
IAO_0000118: M-TriDAP
subclass of: peptide

NOD1
type: Class
subclass of: cytosolic protein

NOD2
type: Class
subclass of: cytosolic protein

Thrombin Receptor Activator Peptide 6
type: Class
IAO_0000118: SFLLRN
subclass of: peptide

Thrombopoietin
type: Class
subclass of: secreted

Z-Leu-Leu-Leu-al
type: Class
IAO_0000118: MG132
subclass of: peptide

Adenosine diphosphate
type: Class
subclass of: nucleotide

Adenosine triphosphate
type: Class
IAO_0000118: ATP
subclass of: nucleotide

Creatine kinase
type: Class
IAO_0000118: creatine phosphokinase
subclass of: kinase

D-galactose
type: Class
subclass of: carbohydrate

DYRKtide peptide
type: Class
subclass of: peptide

Kemptide peptide
type: Class
subclass of: peptide

S6 peptide
type: Class
subclass of: peptide

Suc-LLVY-aminoluciferin
type: Class
subclass of: peptide

Z-RLRGG-aminoluciferin
type: Class
subclass of: peptide

14LckpCAP394 peptide
type: Class
subclass of: peptide

[125I]Y10-neuropeptide S
type: Class
subclass of: peptide

Ac-DEVD-AFC
type: Class
subclass of: peptide

Ac-DEVD-CHO
type: Class
IAO_0000115: Ac-DEVD-CHO is an inhibitor of caspase-3/7 (DEVDase) activity.
subclass of: peptide

Ac-LEHD-AMC
type: Class
subclass of: peptide

Ac-WEHD-AFC
type: Class
subclass of: peptide

Ac-WEHD-CHO
type: Class
IAO_0000115: Ac-Trp-Glu-His-Asp-CHO Very potent reversible inhibitor of caspase-1 (ICE) that contains the optimal tetrapeptide recognition motif for this enzyme. With a Ki of 56 pM, it displays the most potent reversible, peptide-based inhibitors described for any protease. For caspase-8 a Ki of 21.1 nM has been reported.
subclass of: peptide

AK295 peptide
type: Class
IAO_0000115: selective calpain inhibitor AK295
subclass of: peptide

Alpha-D-glucose
type: Class
subclass of: carbohydrate

Apelin-13
type: Class
subclass of: peptide

Pancreatic trypsin inhibitor
type: Class
IAO_0000118: aprotinin
IAO_0000115: The drug aprotinin (Trasylol, Bayer), is the bovine version of the small protein basic pancreatic trypsin inhibitor, or BPTI, which inhibits trypsin and related proteolytic enzymes.
subclass of: secreted

Boc-Gln-Gly-Arg-AMC
type: Class
comment: Substrate for Factor XIIa
subclass of: peptide

Boc-Leu-Gly-Arg-AMC
type: Class
comment: Boc-Leu-Gly-Arg-AMC is a selective fluorogenic substrate for Horseshoe Crab Clotting Enzyme
subclass of: peptide

Boc-Val-Pro-Arg-AMC
type: Class
comment: Substrate for α-Thrombin
subclass of: peptide

Cyclic adenosine monophosphate
type: Class
IAO_0000118: cAMP
subclass of: nucleotide

CBF-his/runx1-biotin protein complex
type: Class
subclass of: protein complex

DABCYL-Thr-Pro-Leu-Lys~Ser-Pro-Pro-Pro-Ser-Pro-Arg-EDANS
type: Class
comment: A fluorogenic FRET peptide with a substrate sequence that is optimized for calpain-1 and -2.
subclass of: peptide

Dy647-pS136-Bad peptide
type: Class
subclass of: peptide

fMLFK-FITC
type: Class
comment: fluorescein-labeled formylmethionine-leucine-phenylalanine-lysine (fmlfk-fitc) substrate for the formylpeptide receptor (FPR) family of G-protein-coupled receptors
subclass of: peptide

Fluorescein Di-beta-D-Glucopyranoside
type: Class
subclass of: carbohydrate

Fluorogenic triple-helical peptide 3
type: Class
subclass of: peptide

fMLFF peptide
type: Class
IAO_0000115: fMLFF peptide is used as a FPR-blocking peptide.
subclass of: peptide

G alpha O-Alexa Fluor 488
type: Class
IAO_0000118: guanine nucleotide-binding protein G(o) subunit alpha isoform a-Alexa Fluor 488
subclass of: G protein

Galanin
type: Class
subclass of: peptide

Glucose
type: Class
subclass of: carbohydrate

Glucose-6-phosphate
type: Class
subclass of: carbohydrate

Glycogen
type: Class
subclass of: carbohydrate

GM-TriDAP peptide
type: Class
IAO_0000115: GM-TriDAP (GlcNAc-MurNAc-L-Ala-D-Glu-mesoDAP), is a muropeptide found mostly in Gram-negative bacterial peptidoglycan.
subclass of: peptide

BODIPY GTP
type: Class
subclass of: nucleotide

H-Leu-NHMec
type: Class
comment: substrate for M1-family alanyl aminopeptidase (M1AAP)
subclass of: peptide

Interleukin-8
type: Class
IAO_0000118: IL-8
subclass of: secreted

LDV peptide
type: Class
IAO_0000115: LDV peptide targeted against the alpha4beta integrin VLA-4
subclass of: peptide

Macrophage inflammatory protein 3 alpha
type: Class
IAO_0000115: MIP3a, CCL20 peptide
subclass of: secreted

Mannose-6-phosphate
type: Class
subclass of: carbohydrate

Melanin-concentrating hormone
type: Class
subclass of: peptide

Muramyl dipeptide
type: Class
subclass of: peptide

Neuropeptide W
type: Class
subclass of: peptide

Neuropeptide S
type: Class
subclass of: peptide

Neuropeptide Y
type: Class
subclass of: peptide

Orexin A
type: Class
subclass of: peptide

Oxytocin
type: Class
subclass of: peptide

Pyr-RTKR-AMC
type: Class
comment: substrate for virus-encoded NS3 serine proteinase
subclass of: peptide

R18 peptide
type: Class
IAO_0000115: The peptide sequence, PHCVPRDLSWLDLEANMCLP, named R18, was identified as an unphosphorylated peptide that binds to 14-3-3 proteins with high affinity (Kd=80 nM). It has been shown to bind to the same amphipathic groove on the surface of 14-3-3 as phosphorylated peptides. R18 can inhibit the formation of the 14-3-3-Raf-1 complex, reduce Raf-1 dependent transcriptional activity in cells and block the activation of ExoS by 14-3-3. It binds to all the 14-3-3 isoforms with equal affinities. This peptide is useful for competitive inhibition experiments.
subclass of: peptide

Resorufin alpha-D-pyranoside
type: Class
subclass of: carbohydrate

Resorufin beta-D-glucopyranoside
type: Class
subclass of: carbohydrate

Rhodamine-RGS12-GoLoco peptide
type: Class
subclass of: peptide

RS repeat peptide
type: Class
subclass of: peptide

Sphingosine 1-phosphate
type: Class
subclass of: lipid

Suc-Ala-Ala-Pro-Phe-AMC
type: Class
comment: Substrate for Chymotrypsin.
subclass of: peptide

Thyroid-stimulating hormone
type: Class
subclass of: secreted

Thyrotropin-releasing hormone
type: Class
subclass of: peptide

TMR-pS259-Raf peptide
type: Class
comment: modulators of 14-3-3 proteins The 14-3-3 proteins are the prototype for a novel class of protein modules that can recognize phosphoserine/threonine (pS/T)-containing motifs in a variety of signaling proteins. To date, 14-3-3 proteins have been reported to bind more than 200 client proteins. Through these interactions, 14-3-3 proteins play important roles in a wide range of vital regulatory processes, such as Bad-induced apoptosis, Raf-1-mediated cell proliferation, and Cdc25-regulated cell cycle progression.
subclass of: peptide

Ubiquitin-AMC
type: Class
comment: Ubiquitin-AMC is a fluorogenic substrate for a wide range of deubiquitinating enzymes (DUBs), including ubiquitin C-terminal hydrolases (UCHs) and ubiquitin specific proteases (USPs). UBIQUITIN-7-AMIDO-4-METHYLCOUMARIN
subclass of: cytosolic protein

Ubiquitin-Rho
type: Class
subclass of: cytosolic protein

Ubiquitin vinyl sulfone
type: Class
IAO_0000115: For use in the detection and identification of deubiquitinylating enzymes
subclass of: cytosolic protein

ULight poly-GT
type: Class
comment: This random polymer is a Tyrosine kinase substrate.
subclass of: peptide

WKYMVm peptide
type: Class
IAO_0000115: Selective agonist for the formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM) and FPR3 (EC50 = 3 nM), expressed on immune cells. Trp-Lys-Tyr-Met-Val-D-Med-NH2
subclass of: peptide

Z-Arg-Arg-AMC
type: Class
comment: Substrate for Cathepsin B
subclass of: peptide

Z-Phe-Arg-AMC
type: Class
comment: This is a fluorescent kallikrein substrate, Abs/Em=353/442 nm.
subclass of: peptide

guanosine diphosphate
type: Class
IAO_0000118: GDP
subclass of: nucleotide

guanosine triphosphate
type: Class
IAO_0000118: GTP
subclass of: nucleotide

nucleotide
type: Class
subclass of: biological macromolecule

carbohydrate
type: Class
comment: Import the ligands from PRO with IDs
subclass of: BAO_0003043
subclass of: biological macromolecule
deprecated: true
IAO_0000116: [BAO v 2.8.18 (Oct 2025)]
IAO_0000118: http://purl.obolibrary.org/obo/CHEBI_16646

lipopolysaccharide
type: Class
IAO_0000118: LPS
subclass of: carbohydrate

DNA vector
type: Class
IAO_0000115: The plasmid, phagemid or viral genome that is used to recombinantly clone the DNA molecule of interest to be introduced into a host cell (bacterial, eukaryotic), where it can independently replicate.
subclass of: biological macromolecule

Serum albumin
type: Class
IAO_0000118: Bovine serum albumin
IAO_0000118: BSA
subclass of: secreted

Microtubule-associated protein tau
type: Class
subclass of: cytosolic protein

Mitogen-activated protein kinase 14
type: Class
subclass of: kinase

his tag
type: Class
subclass of: peptide

myc tag
type: Class
subclass of: peptide

HA tag
type: Class
subclass of: peptide

protein complex
type: Class
IAO_0000115: Two or more proteins interact to form a stable complex. Each of the members of this complex has a distinct role in mediating the overall function of the complex, which can be as a chaperone (DnaK, DnaJ and grpE), an enzyme (mitochondrial respiratory complexes), a signaling complex (G-proteins), etc. It can be viewed as a quaternary structure of the proteins.
subclass of: biological macromolecule

protein subunit
type: Class
IAO_0000115: The individual protein molecule of a protein complex. In the complex, it associates with other protein subunits which are either the same or different, e.g., hemoglobin, microtubule, etc.
subclass of: biological macromolecule

Chlorocebus aethiops
type: Class
subclass of: mammalian

Infectious bronchitis virus
type: Class
subclass of: virus

BJ
type: Class

LYMP2-010
type: Class

LYMP2-001
type: Class

LYMP2-012
type: Class

LYMP2-014
type: Class

LYMP2-016
type: Class

BSC-1
type: Class

LYMP2-018
type: Class

LYMP2-020
type: Class

LYMP2-022
type: Class

LYMP2-024
type: Class

U3A
type: Class

LYMP2-026
type: Class

MV-4-11
type: Class

LYMP2-007
type: Class

LYMP2-006
type: Class

LYMP2-002
type: Class

LYMP2-025
type: Class

LYMP2-023
type: Class

LYMP2-021
type: Class

LYMP2-019
type: Class

LYMP2-017
type: Class

RBL-2H3
type: Class

LYMP2-013
type: Class

LYMP2-011
type: Class

LYMP2-009
type: Class

LYMP2-005
type: Class

LYMP2-004
type: Class

LYMP2-003
type: Class

LYMP1-003
type: Class

LYMP1-002
type: Class

C6
type: Class

LYMP2-008
type: Class

MSC 80
type: Class

LYMP2-015
type: Class

OCI-Ly3
type: Class

C2C12
type: Class

HEC-1-A
type: Class

WRO
type: Class

N2a
type: Class

SK-BR-3
type: Class

H4
type: Class

ML-2
type: Class

KOPN-8
type: Class

PPC-1
type: Class

CSM14.1
type: Class

BSR
type: Class
IAO_0000115: A clone of BHK (Baby hamster kidney) cells.

regulation of catalytic activity
type: Class

EdU
type: Class
subclass of: nucleotide

Anti-MPM-2
type: Class
comment: Millipore #05-368
IAO_0000115: Recognizes a phosphorylated epitope (S/T)P found in phosphoproteins such as MAP2, HSP70, cdc25, and DNA topoisomerase IIa, most of which are phosphorylated at the onset of mitosis. The number of phosphoproteins recognized by MPM-2 varies from species to species and with the cell type.
subclass of: monoclonal

Cyclic guanosine monophosphate
type: Class
IAO_0000118: cGMP
subclass of: nucleotide

P-selectin glycoprotein ligand 1
type: Class
subclass of: generic membrane protein

[35S]GTP-gamma S
type: Class
subclass of: nucleotide

Mitogen-activated protein kinase 1
type: Class
subclass of: kinase

calcium-mediated signaling using intracellular calcium
type: Class

G-protein coupled receptor signaling
type: Class

cAMP-mediated
type: Class

plasmid DNA construct
type: Class
subclass of: DNA construct

disease
type: Class
deprecated: true
subclass of: assay biology component

anatomical entity
type: Class
deprecated: true
subclass of: assay biology component

cell line cell
type: Class
deprecated: true
subclass of: assay biology component

binding site
type: Class
subclass of: assay biology component

transcription factor binding site
type: Class
subclass of: binding site

DNA region
type: Class
IAO_0000115: The categorization of different functional or non-functional elements in DNA.
subclass of: assay biology component

regulatory region
type: Class
IAO_0000115: The DNA region that is involved in initiating and modulating transcription.
subclass of: DNA region

transcribed region
type: Class
IAO_0000115: The region of a gene that codes for RNA.
subclass of: DNA region

artificial regulatory region
type: Class
IAO_0000115: A synthetic DNA element that is known to be regulated by a transcription factor/s, which is cloned upstream of a gene of interest.
subclass of: regulatory region

foreign promoter region
type: Class
IAO_0000115: The regulatory DNA from a non-native gene, e.g., the regulatory region from the actin gene being cloned upstream of the myosin gene in a DNA construct.
subclass of: regulatory region

native promoter region
type: Class
IAO_0000115: The regulatory DNA from a native gene, e.g., the regulatory region from the actin gene being cloned upstream of the actin gene in a DNA construct.
subclass of: regulatory region

beta galactosidase gene
type: Class
subclass of: gene

chloramphenicol acetyl transferase gene
type: Class
subclass of: gene

green flourescent protein gene
type: Class
subclass of: gene

luciferase gene
type: Class
subclass of: gene

permanent cell line
type: Class
comment: has associated disease some disease or is bearer of disease (relation in new RO) Disease import from DOID
IAO_0000115: A cell line that is immortalized.
deprecated: true

Caspase-3
type: Class
comment: P42574
subclass of: generic hydrolase

DEVD-NucView 488
type: Class
subclass of: peptide

cellular component
type: Class
IAO_0000115: The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together (from Gene Ontology).
deprecated: true
subclass of: assay biology component

Glutathione
type: Class
subclass of: peptide

biological macromolecule
type: Class
subclass of: assay biology component

assay biology component
type: Class

Histone H3.3
type: Class
comment: P84243
subclass of: protein

G2/mitotic-specific cyclin-B1
type: Class
IAO_0000118: cyclin-B1
comment: P14635
subclass of: protein

Antigen KI-67
type: Class
IAO_0000118: Ki67
comment: P46013
subclass of: protein

Retinoblastoma-associated protein
type: Class
IAO_0000118: Retinoblastoma protein
comment: P06400
subclass of: protein

Transcription factor AP-1
type: Class
IAO_0000118: c-jun
comment: P05412
subclass of: transcription factor

Annexin A5
type: Class
IAO_0000118: Annexin V
comment: P08758
subclass of: cytosolic protein

E-selectin
type: Class
comment: P16581
subclass of: adhesion

Vascular cell adhesion protein 1
type: Class
IAO_0000118: VCAM-1
comment: P19320
subclass of: adhesion

Microtubule-associated proteins 1A/1B light chain 3B
type: Class
IAO_0000118: Autophagy-related protein LC3 B
comment: Q9GZQ8
subclass of: protein

Tubulin beta-3 chain
type: Class
IAO_0000118: Tubulin beta-III
comment: Q13509
subclass of: structural

Transcription factor p65
type: Class
IAO_0000118: Nuclear factor NF-kappa-B p65 subunit Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
comment: Q04206
subclass of: transcription factor

primary neuron
type: Class
comment: http://purl.obolibrary.org/obo/CL_0000530
subclass of: primary cell

Aldehyde oxidase
type: Class
IAO_0000115: A protein that has been modified with either a molecular or protein and can be used either as a method of pulling down, antibody binding, luminescense, or tracer
IAO_0000115: An aldehyde oxidoreductase expressed predominantly in the LIVER; LUNGS; and KIDNEY. It catalyzes the oxidation of a variety of organic aldehydes and N-heterocyclic compounds to CARBOXYLIC ACIDS, and also oxidizes quinoline and pyridine derivatives. The enzyme utilizes molybdenum cofactor and FAD as cofactors.
has xref: http://purl.bioontology.org/ontology/MESH/D042931
submitted by: SEED Project - Pistoia Alliance
subclass of: oxidoreductase
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

Broad substrate specificity ATP-binding cassette transporter ABCG2
type: Class
subclass of: transporter
IAO_0000115: Broad substrate specificity ATP-binding cassette transporter ABCG2 is encoded by the human ABCG2 gene. This protein is involved in the transport of urate, heme, porphyrin and xenobiotics.
has xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C21253
submitted by: SEED Project - Pistoia Alliance

Bile salt export pump
type: Class
subclass of: transporter
IAO_0000115: Bile salt export pumpis encoded by the human ABCB11 gene. This protein plays a role in bile salt secretion.
has xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C123861
submitted by: SEED Project - Pistoia Alliance

EST1
type: Class
IAO_0000115: The protein-coding gene EST1 located on the chromosome XII.
subclass of: gene
has xref: http://purl.obolibrary.org/obo/NCBIGene_850934
submitted by: SEED Project - Pistoia Alliance
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

EST2
type: Class
IAO_0000115: Reverse transcriptase subunit of the telomerase holoenzyme; essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia.
subclass of: gene
has xref: https://www.yeastgenome.org/locus/S000004310
submitted by: SEED Project - Pistoia Alliance
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

Cytochrome P450 1A2
type: Class
IAO_0000115: Cytochrome P450 1A2 is encoded by the human CYP1A2 gene. This protein is involved in the hydroxylation of fatty acids, steroids and xenobiotics.
subclass of: oxidoreductase
has xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17673
submitted by: SEED Project - Pistoia Alliance
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

Cytochrome P450 2B6
type: Class
IAO_0000115: Cytochrome P450 2B6 is encoded by the human CYP2B6 gene. This protein plays a role in the metabolism of steroids and pharmaceuticals.
subclass of: oxidoreductase
has xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C40050
submitted by: SEED Project - Pistoia Alliance
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

Cytochrome P450 2C19
type: Class
IAO_0000115: Cytochrome P450 2C19 is encoded by the human CYP2C19 gene. This protein is involved in steroid, terpenoid and drug metabolism.
subclass of: oxidoreductase
has xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25948
submitted by: SEED Project - Pistoia Alliance
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

Cytochrome P450 2C8
type: Class
IAO_0000115: Cytochrome P450 2C8 is encoded by the human CYP2C8 gene. This protein is involved in the oxidation of steroids, fatty acids, and xenobiotics.
has xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C46001
submitted by: SEED Project - Pistoia Alliance
subclass of: oxidoreductase
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

Cytochrome P450 2C9
type: Class
IAO_0000115: Cytochrome P450 2C9 is encoded by the human CYP2C9 gene. This protein is involved in the oxidation of fatty acids, steroids and xenobiotics.
has xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28750
submitted by: SEED Project - Pistoia Alliance
subclass of: oxidoreductase
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

Cytochrome P450 3A4
type: Class
IAO_0000115: Cytochrome P450 3A4 is encoded by the human CYP3A4 gene. This protein is involved in the oxidation of steroids, fatty acids and xenobiotics.
has xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17573
submitted by: SEED Project - Pistoia Alliance
subclass of: oxidoreductase
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

Cytochrome P450 2D12
type: Class
IAO_0000115: This protein is involved in steroid, terpenoid and drug metabolism.
has xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16484
submitted by: SEED Project - Pistoia Alliance
subclass of: oxidoreductase
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

Cytochrome P450 2D9
type: Class
IAO_0000115: This protein is involved in steroid, terpenoid and drug metabolism.
has xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16484
submitted by: SEED Project - Pistoia Alliance
subclass of: oxidoreductase
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

Cytochrome P450 2D6
type: Class
IAO_0000115: Cytochrome P450 2D6 is encoded by the human CYP2D6 gene. This protein plays a role in flavoprotein metabolism.
has xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17287
submitted by: SEED Project - Pistoia Alliance
subclass of: oxidoreductase
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

Cytochrome P450 3A7
type: Class
IAO_0000115: Cytochrome P450 3A7 is encoded by the human CYP3A7 gene. This protein plays a role in the oxidation of steroids, fatty acids, and xenobiotics.
has xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C46000
submitted by: SEED Project - Pistoia Alliance
subclass of: oxidoreductase
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

Epoxide hydrolase 1
type: Class
subclass of: enzyme
IAO_0000115: Epoxide hydrolase 1 is encoded by the human EPHX1 gene. This protein is involved in the hydrolysis of cyclic organic compounds.
has xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16860
submitted by: SEED Project - Pistoia Alliance

Cytochrome P450 3A5
type: Class
IAO_0000115: Cytochrome P450 3A5 is encoded by the human CYP3A5 gene. This protein is involved in the oxidation of steroids, fatty acids, and xenobiotics.
has xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45999
submitted by: SEED Project - Pistoia Alliance
subclass of: oxidoreductase
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

Cytochrome P450 3A10
type: Class
IAO_0000115: This protein is involved in steroid, terpenoid and drug metabolism.
has xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16484
submitted by: SEED Project - Pistoia Alliance
subclass of: oxidoreductase
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

Cytochrome P450 2D11
type: Class
IAO_0000115: This protein is involved in steroid, terpenoid and drug metabolism.
has xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16484
submitted by: SEED Project - Pistoia Alliance
subclass of: oxidoreductase
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

Multidrug and toxin extrusion protein 1
type: Class
subclass of: transporter
IAO_0000115: Multidrug and toxin extrusion protein 1 is encoded by the human SLC47A1 gene. This protein plays a role in transport of cationic drugs across membranes.
has xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C113566
submitted by: SEED Project - Pistoia Alliance

Multidrug and toxin extrusion protein 2
type: Class
subclass of: transporter
IAO_0000115: Multidrug and toxin extrusion protein 2 is encoded by the human SLC47A2 gene. This protein is involved in both excretion of toxic electrolytes and secretion of cationic drugs.
has xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C113569
submitted by: SEED Project - Pistoia Alliance

ATP-dependent translocase ABCB1
type: Class
subclass of: enzyme
IAO_0000115: A protein that is a translation product of the human ABCB1 gene.
has xref: http://purl.obolibrary.org/obo/PR_000001891
submitted by: SEED Project - Pistoia Alliance

ATP-binding cassette sub-family C member 2
type: Class
subclass of: transporter
IAO_0000115: A protein that is a translation product of the human ABCC2 gene.
has xref: http://purl.obolibrary.org/obo/PR_000003558
submitted by: SEED Project - Pistoia Alliance

ATP-binding cassette sub-family C member 3
type: Class
subclass of: transporter
IAO_0000115: A protein that is a translation product of the human ABCC3 gene.
has xref: http://purl.obolibrary.org/obo/PR_000003559
submitted by: SEED Project - Pistoia Alliance

Solute carrier family 15 member 1
type: Class
subclass of: transporter
IAO_0000115: A protein that is a translation product of the human SLC15A1 gene.
has xref: http://purl.obolibrary.org/obo/PR_000014940
submitted by: SEED Project - Pistoia Alliance

FMO3
type: Class
subclass of: gene
IAO_0000115: The protein-coding gene FMO3 (flavin containing monooxygenase 3).
has xref: http://identifiers.org/ncbigene/2328
submitted by: SEED Project - Pistoia Alliance
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

Amine oxidase [flavin-containing] A
type: Class
subclass of: enzyme
IAO_0000115: Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues.
has xref: https://www.ebi.ac.uk/interpro/protein/UniProt/P21397/
submitted by: SEED Project - Pistoia Alliance

Amine oxidase [flavin-containing] B
type: Class
subclass of: enzyme
IAO_0000115: Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin MPTP, with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues.
has xref: https://www.uniprot.org/uniprotkb/P27338/entry
submitted by: SEED Project - Pistoia Alliance

Solute carrier family 22 member 6
type: Class
subclass of: transporter
IAO_0000115: A protein that is a translation product of the human SLC22A6 gene.
has xref: http://purl.obolibrary.org/obo/PR_000014993
submitted by: SEED Project - Pistoia Alliance

Solute carrier family 22 member 7
type: Class
subclass of: transporter
IAO_0000115: A protein that is a translation product of the human SLC22A7 gene.
has xref: http://purl.obolibrary.org/obo/PR_000014994
submitted by: SEED Project - Pistoia Alliance

Solute carrier family 22 member 8
type: Class
subclass of: transporter
IAO_0000115: A protein that is a translation product of the SLC22A8 gene.
has xref: http://purl.obolibrary.org/obo/PR_Q8R0S9
submitted by: SEED Project - Pistoia Alliance

Solute carrier organic anion transporter family member 1B1
type: Class
subclass of: transporter
IAO_0000115: Solute carrier organic anion transporter family member 1B1 is encoded by the human SLCO1B1 gene. This protein is involved in the sodium-independent uptake of endogenous compounds in the liver.
has xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C106616
submitted by: SEED Project - Pistoia Alliance

Solute carrier organic anion transporter family member 1B3
type: Class
subclass of: transporter
IAO_0000115: A sodium-independent organic anion transporter that functions in the uptake of various drugs and endogenous compounds including estradiol; taurocholate; leukotriene c4; and methotrexate.
has xref: http://purl.bioontology.org/ontology/MESH/D000074542
submitted by: SEED Project - Pistoia Alliance

Solute carrier organic anion transporter family member 2B1
type: Class
subclass of: transporter
IAO_0000115: Solute carrier organic anion transporter family member 2B1 is encoded by the human SLCO2B1 gene. This protein is involved in transport of organic anions and may function in regulation of placental uptake of sulfated steroids.
has xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C105431
submitted by: SEED Project - Pistoia Alliance

Solute carrier family 22 member 1
type: Class
subclass of: transporter
IAO_0000115: Solute carrier family 22 member 1 is encoded by the human SLC22A1 gene. This protein is involved in bidirectional cation transport.
has xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C105075
submitted by: SEED Project - Pistoia Alliance

Steroid transmembrane transporter SLC22A24
type: Class
subclass of: transporter
IAO_0000115: A protein that is a translation product of the human SLC22A24 gene.
has xref: http://purl.obolibrary.org/obo/PR_000030620
submitted by: SEED Project - Pistoia Alliance

UDP-glucuronosyltransferase 1A1
type: Class
IAO_0000115: A protein that is a translation product of the human UGT1A1 gene.
has xref: http://purl.obolibrary.org/obo/PR_000017048
submitted by: SEED Project - Pistoia Alliance
subclass of: transferase
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

UDP-glucuronosyltransferase 1A3
type: Class
IAO_0000115: A protein that is a translation product of the human UGT1A3 gene.
has xref: http://purl.obolibrary.org/obo/PR_000017050
submitted by: SEED Project - Pistoia Alliance
subclass of: transferase
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

UDP-glucuronosyltransferase 1A4
type: Class
IAO_0000115: A protein that is a translation product of the human UGT1A4 gene.
has xref: http://purl.obolibrary.org/obo/PR_000017051
submitted by: SEED Project - Pistoia Alliance
subclass of: transferase
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

UDP-glucuronosyltransferase 1-6
type: Class
IAO_0000115: UDP-glucuronosyltransferase 1-6 is encoded by the human UGT1A6 gene. This protein is involved in the elimination of phenolic metabolites.
has xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C105574
submitted by: SEED Project - Pistoia Alliance
subclass of: transferase
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

UDP-glucuronosyltransferase 1A7
type: Class
IAO_0000115: A protein that is a translation product of the mouse Ugt1a7c gene.
has xref: http://purl.obolibrary.org/obo/PR_000017223
submitted by: SEED Project - Pistoia Alliance
subclass of: transferase
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

UDP-glucuronosyltransferase 1A8
type: Class
IAO_0000115: A protein that is a translation product of the human UGT1A8 gene.
has xref: http://purl.obolibrary.org/obo/PR_000017055
submitted by: SEED Project - Pistoia Alliance
subclass of: transferase
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

UDP-glucuronosyltransferase 1A9
type: Class
IAO_0000115: A PPAR alpha and PPAR gamma target gene. The enzyme plays an important role in elimination and detoxification of drugs, xenobiotics, and metabolizing endogenous compounds, including catecholestrogens and fibrates.
has xref: http://purl.bioontology.org/ontology/MESH/D000090264
submitted by: SEED Project - Pistoia Alliance
subclass of: transferase
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

UDP-glucuronosyltransferase 1A10
type: Class
IAO_0000115: A protein that is a translation product of the human UGT1A10 gene.
has xref: http://purl.obolibrary.org/obo/PR_000017049
submitted by: SEED Project - Pistoia Alliance
subclass of: transferase
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

UDP-glucuronosyltransferase 2B4
type: Class
IAO_0000115: A protein that is a translation product of the human UGT2B4 gene
has xref: http://purl.obolibrary.org/obo/PR_000017064
submitted by: SEED Project - Pistoia Alliance
subclass of: transferase
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

UDP-glucuronosyltransferase 2B7
type: Class
IAO_0000115: UDP-glucuronosyltransferase 2B7 is encoded by the human UGT2B7 gene. This protein plays a role in regulating the metabolism of estrogen metabolites.
has xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C105577
submitted by: SEED Project - Pistoia Alliance
subclass of: transferase
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

UDP-glucuronosyltransferase 2B10
type: Class
IAO_0000115: A protein that is a translation product of the human UGT2B10 gene.
has xref: http://purl.obolibrary.org/obo/PR_000017059
submitted by: SEED Project - Pistoia Alliance
subclass of: transferase
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

UDP-glucuronosyltransferase 2B15
type: Class
IAO_0000115: UDP-glucuronosyltransferase 2B15 is encoded by the human UGT2B15 gene. This protein is involved in the catabolism of xenobiotics and steroids.
has xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C105422
submitted by: SEED Project - Pistoia Alliance
subclass of: transferase
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

UDP-glucuronosyltransferase 2B23
type: Class
IAO_0000115: A protein that contains a C-terminal UDPGT domain that in active form catalyzes the transfer of glucuronic acid to a wide variety of exogenous and endogenous lipophilic substrates.
has xref: http://purl.obolibrary.org/obo/PR_000024849
submitted by: SEED Project - Pistoia Alliance
subclass of: transferase
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

Sodium/bile acid cotransporter
type: Class
subclass of: transporter
IAO_0000115: A protein that is a translation product of the SLC10A1 gene
has xref: http://purl.obolibrary.org/obo/PR_000014917
submitted by: SEED Project - Pistoia Alliance

UDP-glucuronosyltransferase 2B17
type: Class
IAO_0000115: UDP-glucuronosyltransferase 2B17 is encoded by the human UGT2B17 gene. This protein plays a role in the metabolism of steroids and xenobiotics.
has xref: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C105425
submitted by: SEED Project - Pistoia Alliance
subclass of: transferase
IAO_0000116: [EdgeRewiring: BAO v 2.8.14 (April 2025)]

whole organism
type: Class
IAO_0000115: Living multicellular organism.
subclass of: organism
submitted by: Opioid Drug Ontology (ODO) (https://opioiddrugontology.github.io/) - Nicolette Ross (https://orcid.org/0000-0002-4677-2140)
IAO_0000119: https://doi.org/10.1371/journal.pntd.0001762
IAO_0000116: [DefinitionUpdate: BAO v 2.8.15 (May 2025)] [NodeCreation: BAO v 2.8.13 (March 2025)]

Multidrug resistance-associated protein 2
type: Class
subclass of: transporter
IAO_0000115: The multidrug resistance protein 2 (MRP2; ABCC2) is an ATP-binding cassette transporter accepting a diverse range of substrates, including glutathione, glucuronide, and sulfate conjugates of many endo- and xenobiotics.
IAO_0000119: https://doi.org/10.1124/jpet.102.035014
submitted by: Joan Glenny Pescov (https://orcid.org/0009-0008-8186-7058)
IAO_0000116: [BAO v 2.8.17 (Oct 2025)]